High LH, Very High Testosterone, Suspected Pituitary Tumor

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Dezertfox

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It will probably suppress your T too. But not a big suppression. I don't have much information about how to raise T naturally.
Are you taking 0.5 mg ever day? Is it a continuous thing or are you planning to take it for some time only
 

LCohen

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Are you taking 0.5 mg ever day? Is it a continuous thing or are you planning to take it for some time only

Starting dose is 0.50mg straight 3 days. 1 day off. Then 3 days again. That's the first week.

It instantly stopped my hair loss.

Now using 0.25 (half pill) mg for EOD - E3D. Sometimes 0.50 again.

Can't see a side effect. I would give it a try.
 
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Dezertfox

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Here's an interesting study I found -

"
Plasma DHEA and DHEA-S levels were significantly higher (P less than 0.001) in women with elevated prolactin levels, due either to chronic treatment with psychotropic drugs or to a prolactinoma, than in untreated controls. This increase was also observed in 3 male patients with prolactinoma. It is suggested that this increase is the consequence of a direct effect of prolactin on the adrenal cortex and that prolactin might be responsible for the ACTH independent andrenocortical androgen secretion."

So maybe bringing down my prolactin levels would help bringing down DHEA S and hair loss too i guess
 

GorillaHead

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So i have long beleived that calcitriol and the VDR were the main thing behind Androgenic hairloss.

Even from an evolutionary standpoint.

Most of the time people from very hot areas have better hair. Of course this is a genaralization.


Calcitriol the activated from of d3 has a powerful effect on hair.

Vdr delete rats, grow no hair.


Quick search shows
Dexamethasone Up regulates vdr transcription.

Vitamin D and androgens interact.

Vitamin D is a hormone

And vitamin D helps in prostate cancer.

But its probably not as simple as ingesting tons of vitamin D. Tissue and serum levels are something to look at.

Calcitriol inhibit IL-17a
IL-17a inplicated in psoriasis. When inhibited one man saw tremendous change in his hair. Positive.

So Dexamethasone may be related to that in my opinion as it also inhibit il-17a very well
 
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Dezertfox

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Starting dose is 0.50mg straight 3 days. 1 day off. Then 3 days again. That's the first week.

It instantly stopped my hair loss.

Now using 0.25 (half pill) mg for EOD - E3D. Sometimes 0.50 again.

Can't see a side effect. I would give it a try.

I was thinkin
IMO there is nothing wrong with these results. Your LH is in range, in pituitary tumors the LH is usually much much higher but let's see what what the other results show. Same with total T levels or DHEA. In tumors, whether of adrenal/pituitary or ectopic origin, the measured steroids are typically very high, often multiples times above top range. The free T is high, which suggests SHBG is low, so if he has not measured it I would ask him to add it to the other tests he is running.
Spironolactone is anti-androgenic and to prescribe it to a person whose total T is barely elevated and without additional evidence of an androgen-producing tumor is nothing short of a crime. If your other results come back normal I would seriously consider suing that doctor or filing a complaint against him.
'
Hey Haidut, the updated results came back..Can you please take a look when you get the chance?

I had reduced my thyroid medication for t4 to once every 2-3 days since it had a higher half life and I thought maybe I have too much in the system. My prolactin is very high which can be caused by a tumor as well or maybe due to high TSH?

Another thing I am wondering is people with High T have Low prolactin and vice versa how can I have both high at the same time? What if prolactin was even higher when the thyroid levels were good? Since T has gone down a bit with increasing TSH, maybe prolactin went down too?

Estradiol - 23 (7-42)
Prolactin - 28 (4-15.2)
Testosterone - 849
Free T - 19.9
FSH - 4.2 (1.5-12.4)
LH-6.4
TSH - 12 (0.45-4.5)
DHEA S - 403
Parathyroid - 23 (15-65)
IGF1- 147 (98-282)
Cholestrol total - 208
Triglycerides -153
 

LCohen

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So i have long beleived that calcitriol and the VDR were the main thing behind Androgenic hairloss.

Even from an evolutionary standpoint.

Most of the time people from very hot areas have better hair. Of course this is a genaralization.


Calcitriol the activated from of d3 has a powerful effect on hair.

Vdr delete rats, grow no hair.


Quick search shows
Dexamethasone Up regulates vdr transcription.

Vitamin D and androgens interact.

Vitamin D is a hormone

And vitamin D helps in prostate cancer.

But its probably not as simple as ingesting tons of vitamin D. Tissue and serum levels are something to look at.

Calcitriol inhibit IL-17a
IL-17a inplicated in psoriasis. When inhibited one man saw tremendous change in his hair. Positive.

So Dexamethasone may be related to that in my opinion as it also inhibit il-17a very well

Good point.

Paricalcitol (Vit D derv) also reduces skin fibrosis and inhibits il-17

Paricalcitol Reduces Peritoneal Fibrosis in Mice through the Activation of Regulatory T Cells and Reduction in IL-17 Production
 

haidut

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I was thinkin

'
Hey Haidut, the updated results came back..Can you please take a look when you get the chance?

I had reduced my thyroid medication for t4 to once every 2-3 days since it had a higher half life and I thought maybe I have too much in the system. My prolactin is very high which can be caused by a tumor as well or maybe due to high TSH?

Another thing I am wondering is people with High T have Low prolactin and vice versa how can I have both high at the same time? What if prolactin was even higher when the thyroid levels were good? Since T has gone down a bit with increasing TSH, maybe prolactin went down too?

Estradiol - 23 (7-42)
Prolactin - 28 (4-15.2)
Testosterone - 849
Free T - 19.9
FSH - 4.2 (1.5-12.4)
LH-6.4
TSH - 12 (0.45-4.5)
DHEA S - 403
Parathyroid - 23 (15-65)
IGF1- 147 (98-282)
Cholestrol total - 208
Triglycerides -153

I already responded via PM.
 
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Dezertfox

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Messages
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I already responded via PM.
Hi Haidut, I switched from t4 to t4+t3..and my t3 is still mid range at 3.0..My TSH went down from 12 to 4 but my prolactin is still at 28 like it was before..Do you think i should be getting a MRI as the doctor suggested? Since my TSH came down but prolactin is still high?
 

marsaday

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Hashimotos is ilkley the issue here

If you are not making enough thyroid the adrenals will over compensate.

You need to take the correct thyroid dose to control the tsh to be around 1.

It is harder with hashis to do this so you will need to focus on diet to help lower inflammation.
 
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Dezertfox

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Hashimotos is ilkley the issue here

If you are not making enough thyroid the adrenals will over compensate.

You need to take the correct thyroid dose to control the tsh to be around 1.

It is harder with hashis to do this so you will need to focus on diet to help lower inflammation.

Thanks! That makes sense..is there a link between adrenals and prolactin? My adrenals are always in overdrive shown by high dhea s and cortisol levels..so are my T and free T..problem is my adrenals seemed to be in overdrive even when my tsh was under 1 with t4 only..t3 was always mid range for me though and never higher.
 

marsaday

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Physiologic levels of prolactin in males enhance luteinizing hormone-receptors in Leydig cells, resulting in testosterone secretion, which leads to spermatogenesis.[14]

This is a quote from the wiki page on prolactin. It also says MDMA use will up prolactin.

Higher prolactin levels can lead to lower testosterone i think. It seems common for low testosterone men to have higher prolactin levels.

Not sure about the link between prolactin and adrenals though.

Your energy systems sound out of balance. Why this is taking place can be down to many reasons, but hashimotoes really complicates things and people need to look into how to lower inflammation in the body. Don't over use iodine if you have been doing this.

When the thyroid system is better balanced it will mean the adrenal system will balance up better. Low thyroid people often have low cortisol and DHEA, but this is after a good while as this condition plays out. Initially when the thyroid tails off the adrenals will rise to compensate and this sounds where you are.

There is a lot more investigation to do here.

How is sleep? Sleep has to be regular with the timings of getting off and waking. IF you do shift work this may have some bearing on the results.
 

guapeat

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Mar 25, 2020
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I went to see the doctor today as a follow up to my bloodwork.

Since my LH is high and T is also very high without any supplements at the time of this bloodwork other than synthroid, my doctor suspects a pituitary tumor. He has ordered more tests like FSH, Prolactin, estradiol,IGF1. He also prescribed spironolactone 50 mg a day now..I don't think I will be taking it since it's used by transgenders?

I am worried right now and looking for answers. Anyone has idea why T and LH would be so high? High estrogen? Any Peat explanations for this?

I have Hashimotos as well and I wrote this post the other day.

My Bloodwork Over The Last Year, Suffering For 20 Years. Please Help

DHEA S - 441 (138-475) ALWAYS in the top range, suggest adrenal overdrive? Any tips would help..
HbA1c- 5.2..
Test - 1100 (264-900)
Free test - 37.8( 9-26)
Testosterone has been very high in the last 2 tests, this time it's 30% over range, is this due to adrenal overdrive? I am worried..
LH- 7.1 ( seems to be a bit high as well)

Seems to make sense the high LH en Test, as LH stimulates the gonads in producing Test. Did you found a pituitary tumor? I have and pituitary adenoma causing High prolactin, and low LH and Test.
 
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Dezertfox

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Update- I was using minox with Fin topically, when i stopped the T went up. No pituitary issues in MRI. All my issues are related to sleep apnea causing fatigue and hormone disruptions - high cortisol(wake up 45 times per night as per sleep study most unaware), suppressed thyroid, etc. Was planning to get surgery for the apnea but this stupid MFing coronavirus ***t caused cancellation and I lost my job as well. Kinda f****d now.
 

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