Hair Steroid Profiling Reveals Racial Differences in Male Pattern Baldness between Korean and Caucasian Populations (PDF Download Available)
As biological fluids demonstrate no correlation between androgen levels and MPB (Phillipou and Kirk, 1981),
steroids extracted from the hair shaft were compared in balding and normal Korean and Caucasian subjects.
Human hair fibers were obtained by cutting the proximal part hair from the vertex and occipital scalp, and
the steroid levels were evaluated as described
NK = normal korean, BK = balding korean. NC = normal Caucasian ,BC = balding Caucasian.
1. As expected, DHT levels were increased in BK compared to Nk and increased in BC compared to NC but an interesting thing was that normal koreans had 3 times higher hair DHT than normal caucasians.
2. T levels also increased in BC and BK compared to controls but hair T levels in normal koreans were 3-4 times higher than normal Cauca. Hair T levels for NK were 2 times higher than BC.
3. Paradox - 5-beta-DHP(dihydroprogestrone) - Balding koreans had nearly 9 times 5-beta-DHP in their hair compared to normal koreans(187 vs 20) while 5-beta-DHP was decreased in balding caucasians compared to normal caucasians (39.34 vs 54.29)
As biological fluids demonstrate no correlation between androgen levels and MPB (Phillipou and Kirk, 1981),
steroids extracted from the hair shaft were compared in balding and normal Korean and Caucasian subjects.
Human hair fibers were obtained by cutting the proximal part hair from the vertex and occipital scalp, and
the steroid levels were evaluated as described
NK = normal korean, BK = balding korean. NC = normal Caucasian ,BC = balding Caucasian.
1. As expected, DHT levels were increased in BK compared to Nk and increased in BC compared to NC but an interesting thing was that normal koreans had 3 times higher hair DHT than normal caucasians.
2. T levels also increased in BC and BK compared to controls but hair T levels in normal koreans were 3-4 times higher than normal Cauca. Hair T levels for NK were 2 times higher than BC.
3. Paradox - 5-beta-DHP(dihydroprogestrone) - Balding koreans had nearly 9 times 5-beta-DHP in their hair compared to normal koreans(187 vs 20) while 5-beta-DHP was decreased in balding caucasians compared to normal caucasians (39.34 vs 54.29)