@Tarmander thank you for your excellent effort for summarising gboldeuv post. Much of it makes sense, especially the individual requirements for people. No cookie cutter protocol and if you are going to supplement then you better know what you are doing. However, my brain is a tad frazzled here.
I understand when hormones are high; receptors will be low and supplementing hormones; receptors are discarded in an attempt to protect from receptor interacting with excess hormones. If we have a healthy liver (which is why all those liver flushes) all is well and metabolism is firing optimally.
As @mattyb so eloquently pointed out.
It is the fat accumulation in liver tissue (fatty liver or NALD) and other organs that drives the metabolic syndrome. This fat rather than fat stored in adipose tissue correlates with low SHBG. The presence of unbound hormones triggers hormone receptors to be be down regulated. So it is a protective mechanism. Yes/No??
A healthy liver will efficiently rid excess hormones which are rendered water-soluble and are easily excreted by the liver i,e; methylated, acetylated, glucoronidated, glycinated and optimally excreted via stool (if adequate good fibre is on board) and not via urine, so they don't make their way back to liver for reprocessing.
For efficient detoxification to occur, we need adequate protein, adequate calories as phase 2 - hormones and heavy metals - is energy intensive, Key nutrients required for liver enzymes to do their work: B6, B5, sulphur, zinc, manganese, magnesium, sulpur, selenium and copper.
It makes sense why he does not favour diary and animals meats. Higher hormones for liver enzymes to deal with; especially with meats however; there are positives; such as B6, zinc and sulphur. Though, you could totally do away with meat if you are consuming ample shellfish and fish. There is certainty in getting all the above nutrients + iodine. If you have efficient detoxification pathways, you will be able to also detox PCB and other pollutants. These are not only in seaford; they are abundant everywhere - in the air we breathe, water we drink and foods. If you eat organically grown foods you can reduce these in as little as a week.
When hormones are low, receptors are high because the body is trying to optimise hormone to receptor interactions. However, when body endogenous hormones are low, xenohormones and other molecules also interact with hormone receptor acting as either agonists or antagonists.
Having cortisol high is good because receptors are gone, thus supplementing when there are no receptors, facilitates and optimises detoxification of excess hormones and toxins in the system.
When cortisol is high, it tears down muscles to provide sugar to cells (glyconeogenesis). It also strips away intestinal lining = sensitve gut lining = hyperpermeability of tight junctions. So is he saying that it is better in the short term to catabolise tissue for sugar to facilitate speedy detoxification of hormones and when hormones are cleared, instead of low receptors in the begining, we have much more. This time tough, we have a higher ratio of receptors to hormones instead low ratio. Yes/No???
Even Jason Fung says not to fast if you are high cortisol. Many individuals with high adrenaline and cortisol suffer from anxiety attacks. How can you fast these indivuals without sending them to the hospital emergency department? When you say a fasted state, are they doing water fasts and if they are already in a catabolic state, won't those inflammatory amino acids from muscle breakdown send them into overdrive?
They would need to be on dextrose + sodium/potassium chloride + lactate depending on whether they are high or low in potassium in the cell.
Pushing cortisol higher will only cause more potassium to be lost via urine. Why do we want this? We want this to lower potassium in the cell or only potassium extracellularly??? If you are already high cortisol, you will be low potassium in the cell and high potassium outside the cell and in the urine. Yes/No?
I can understand pushing cortisol up when you are low cortisol but don't quite understand pushing cortisol when already high. That's right to reset those damn receptors. This is making my head spin.
Are we pushing potassium out to reduce progesterone which means that this lowering of potassium = lowering of progesterone which then upregulates /resets the progesterone receptor? As we now have high ratio of progesterone receptors to progesterone hormone, 5a/b reductase is downregulated due to lack of substrate (progesterone) which is what finestride is supposed to do but it doesn't. Because finestride is progestin = receptors will be disgarded and because there is plenty free floating progestin (finestride) 5a/b reductase will convert progesterone/progestin/finestride to a/b pregnanediol. Yes/No?
By raising cortisol, you are redirecting steriod pathway away from 3bhsd to 17 hydroxlase -> CYP21 -> CYP11b1 then pushing cortisol towards cortisone rather than active cortisol via 11bHSD. How are you controlling this step? More potassium and less sodium???
Does the fast activate pathway to cortisone?? Is this how you achieve balanced cortisol and reset?
So in urine we want to see higher cortisone metabolites THE and lower active cortisol metabolites THF.
How would one monitor their potassium levels in the cells if one was doing this protocol at home? Are you using ion selective electrode or some rapid test kit? Testing urine to determine status in the cell?
Am I understanding this correctly? Anyone???
Katarina Dalton says any hint of adrenaline then progesterone can't interact with the progesterone receptor. It is all about the progesterone receptors, yet she recommended supplementation with extremely high levels of progesterone + starch every 3 hours.
The fasting reduces work in respect to digestion and liver detoxification pathways so detoxification pathways are solely focussing of ridding the body of excess hormones. Thus because hormones are now low - cleared from the system; receptors are upregulated to interact with endogenous hormones rather than xenohormones, chemicals and pollutants which have now been cleared from the system.
Digestion is reduced during fasting, acetaldehyde is rapidly cleared via liver detox pathways.
Yes!!
So insensitive progesterone = high cortisol basically cushings or pseudo cushings which is why they feel better supplementing progesterone. However, there is no need to supplement because we can manipulate with minerals instead, by draining potassium out of the cell.
So in my own situation, supplementing pregnenolone, increased progesterone and and cortisol sending my potassium up resulting in cushing like facial features. So now I need to drain the cells of potassium, which will lower progesterone. Focus on increasing cortisol but making sure 11bHSD is converting active cortisol to inactive cortisone. Yes/No??
What about intermittent fasting; will this work with exercise? 40 days is a bloody long time. Can I just live on electrolyte solution for 40 days? Marmalade sounds a better option to me. Still think Peat is not wrong. Context matters. I know Gboldeuv this is non-peat forum but it is important to help people on the RPF work out where they are failing. My cortisol goes up just reading about all the casualties.
The biggest take home message out of all this, is that minerals can do the work of hormones and there should be no reason why a good wholesome varied diet can't achieve this. Minerals in isolation or molecules in isolation is a recipe for regret. I am going to get off my bum and make a few batches of my lovely marmalade and clementine cake. Give my brain a break.
Some feedback would be greatly appreciated. Anyone???
