Effects Of Excess Dietary Iron And Fat On Glucose And Lipid Metabolism

Discussion in 'Articles & Scientific Studies' started by paymanz, Jun 25, 2016.

  1. paymanz

    paymanz Member

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    Effects of excess dietary iron and fat on glucose and lipid metabolism. - PubMed - NCBI

    Abstract
    PURPOSE:
    Diets rich in fat and energy are associated with metabolic syndrome (MS). Increased body iron stores have been recognized as a feature of MS. High-fat diets (HFs), excess iron loading and MS are closely associated, but the mechanism linking them has not been clearly defined. We investigated the interaction between dietary fat and dietary Fe in the context of glucose and lipid metabolism in the body.

    METHODS:
    C57BL6/J mice were divided into four groups and fed the modified AIN-93G low-fat diet (LF) and HF with adequate or excess Fe for 7 weeks. The Fe contents were increased by adding carbonyl iron (2% of diet weight) (LF+Fe and HF+Fe).

    RESULTS:
    High iron levels increased blood glucose levels but decreased high-density lipoprotein cholesterol levels. The HF group showed increases in plasma levels of glucose and insulin and insulin resistance. HF+Fe mice showed greater changes. Representative indices of iron status, such hepatic and plasma Fe levels, were not altered further by the HF. However, both the HF and excess iron loading changed the hepatic expression of hepcidin and ferroportin. The LF+Fe, HF and HF+Fe groups showed greater hepatic fat accumulation compared with the LF group. These changes were paralleled by alterations in the levels of enzymes related to hepatic gluconeogenesis and lipid synthesis, which could be due to increases in mitochondrial dysfunction and oxidative stress.

    CONCLUSIONS:
    High-fat diets and iron overload are associated with insulin resistance, modified hepatic lipid and iron metabolism and increased mitochondrial dysfunction and oxidative stress.
     
  2. Tarmander

    Tarmander Member

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    You have been posting some good studies paymanz
     
  3. Amazoniac

    Amazoniac Member

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    I agree. I've been following most of them and the majority are really interesting ones. Thank you!
     
  4. OP
    paymanz

    paymanz Member

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  5. Mufasa

    Mufasa Member

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    I want a +1 button.
     
  6. What-a-Riot

    What-a-Riot Member

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    I think we all feel that way sometimes. But I also think we're better off without one :grin
     
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