Can someone explain serotonin in the gut vs in the brain and how they interact

[area51puy]

I have trying to convince my mom to stop taking Prozac which she on now for probably 20 years and she is not the happy people you see riding on bikes in those pharmaceutical commercials. She is Quite the opposite.

I was getting her to consider it , but she was doing her own research with all the propaganda out there she believes serotonin in the brain isn’t bad , but does agree that in the gut isn’t so good and she has a history of intestinal issues. But she said that the research she did says serotonin in the gut does not cross the blood brain barrier so it is two separate issues.

So I do understand serotonin in the gut effects gut issues and serotonin in the brain put you more into hibernation metabolism and makes see the world as a threat.

But I wondering how gut serotonin and serotonin in the brain interact on each other and there are many drugs and supplements that are serotonin antagonist, but do some work better in the gut and some that work better in the brain.

I’m just trying to get better understanding and any knowledge in the subject would be appreciated.

 

[Perry Staltic]

95% of 5-HT is made in the gut. Fluoxetine increases serotonin presence in the gut by inhibiting reuptake via SERT.

Fluoxetine doubled the compression-evoked and steady-state 5-HT levels in control and DSS mice.

Analysis of real-time serotonin (5-HT) availability during experimental colitis in mouse - PubMed

Serotonin (5-HT)-containing enterochromaffin (EC) cells of the intestine transduce chemical and mechanical stimuli from the intestinal lumen by releasing 5-HT on to afferent nerve terminals. Dysfunctional mucosal 5-HT signaling has been implicated in heightened visceral sensitivity and altered...

pubmed.ncbi.nlm.nih.gov

SSRIs are 5-HT2B agonists that promote fibrosis, eg, interstitial lung disease

Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects - PubMed

Fluoxetine and other serotonin-specific re-uptake inhibitors (SSRIs) are generally thought to owe their therapeutic potency to inhibition of the serotonin transporter (SERT). However, research in our laboratory showed that it affects, with relatively high affinity the 5-HT2B receptor in cultured...

pubmed.ncbi.nlm.nih.gov

Interstitial lung disease induced by fluoxetine: Systematic review of literature and analysis of Vigiaccess, Eudravigilance and a national pharmacovigilance database - PubMed

We investigated a pulmonary adverse drug reaction possibly induced by fluoxetine, the Interstitial Lung Disease, by performing a systematic review of published case reports on this subject, a review of the World Health Organization VigiAccess database, of the European EudraVigilance database and...

pubmed.ncbi.nlm.nih.gov

 

[Elie]

@Hans has a number of well researched articles with references on his site. Could be a good place to explore this You searched for serotonin » MENELITE