Serotonin Causes Obesity And Diabetes In Humans

[Tarmander]

I think both descriptions (mine and yours) are valid. The people I describe usually go through a period of rage/resentment before turning into...machines. The people you describe are definitely bad, but still they are acting more on emotion than mechanically. True evil is where you talk about murder/rape as if you are ordering burgers. That's what psychiatry calls "personality disorder". Those people do not believe the victims got what they deserved, they simply cannot be bothered by a thought about the "business as usual". It's just work.
I am sure you have met these people who keep insisting that "it was business and not personal". Most specialist doctors over 50 are like that. The Stalins of the world are usually very personal and most often carry their deeds as a revenge for something they thought the world bestowed upon them unfairly. Same with the Columbine boys. Not saying it makes it OK, just that those cases are still...dare I say..."normal" humans. It's the dehumanized, mechanical, serotonergic zombies that are the real concern. You know what's scary - less than 2% of the population are like the Stalins/Columbiners. I did not make up that number, this issue has been studied. But guess what? Every person on SSRI is a "zombie" in the making. And that's 20% of the population, based on official prescription data. Your neighbor is much more likely to ruin your life than a random psycho hiding in the woods and plotting world revenge.

I see what you are saying.

I would say that someone like Stalin needs a lot of zombies to get his work done. You need all those paper pushers and camp guards who don't mind shooting a running prisoner. But then I loop back around and think that to be a prison guard, you had to be a certain type which included anger at life, or at least a disregard for it. Maybe that is what you mean. I have been reading gulag archipelago, so have been thinking about this stuff recently.

 

[Braveheart]

Sorry, kind of off subject lol, but what is supposed to happen as I eat lots of fresh delicious pineapple... and plantain (fried in coco oil and spinkeled w sugar and cinamon)?

 

[haidut]

Sorry, kind of off subject lol, but what is supposed to happen as I eat lots of fresh delicious pineapple... and plantain (fried in coco oil and spinkeled w sugar and cinamon)?

I don't think these provide nearly as much serotonin as the one produced in the gut. So, I doubt they will make anybody fat due to their serotonin content

 

[Braveheart]

I don't think these provide nearly as much serotonin as the one produced in the gut. So, I doubt they will make anybody fat due to their serotonin content

Thanks, Mr Giorgy...it would be hard to ever turn my back on them...they are loaded w good.

 

[Mito]

But none of these drugs are marketed as "serotonin antagonists" for fear of exposing the deadly lie. They are all listed as "serotonin modulators".

Press Releases - Investors - Acadia
NUPLAZID is also the only drug approved by the FDA that preferentially targets 5-HT2A receptors. These receptors are thought to play an important role in Parkinson’s disease psychosis. The unique pharmacology of NUPLAZID establishes a new class of drug - selective serotonin inverse agonists (SSIA) - by not only preferentially targeting 5-HT2A receptors but also avoiding activity at dopamine and other receptors commonly targeted by antipsychotics. Typical Parkinson’s disease therapy consists of drugs that stimulate dopamine to treat patients’ motor symptoms such as tremor, muscle rigidity and difficulty with walking. NUPLAZID does not interfere with patients’ dopaminergic therapy and therefore does not impair their motor function.

This one recently made the news....Reports of death spark concern about Parkinson's drug - CNN

 

[TreasureVibe]

Would enemas aid in flushing out serotonin from the gut?

I can attest that after having had 2 enemas I felt much more relaxed and low serotonin.

 

[SOMO]

Would enemas aid in flushing out serotonin from the gut?

I can attest that after having had 2 enemas I felt much more relaxed and low serotonin.

I don't think it works like that, but enemas will obviously reduce bloating and physically scrub your intestines. This can contribute to the "Clean" and light feeling, but you can achieve the same thing with water/juice fasting.

 

[TreasureVibe]

I don't think it works like that, but enemas will obviously reduce bloating and physically scrub your intestines. This can contribute to the "Clean" and light feeling, but you can achieve the same thing with water/juice fasting.

Thing is, ever since I have done them, even though I have ate alot of garbage food, the feeling hasn't gone away and sometimes I am even scared at how secure it makes me feel. However I don't recommend it due to dangerous electrolytes imbalance.

 

[tonto]

@haidut
Have you run across this research before?:
'Feel-good' hormone serotonin regulates blood sugar concentration

Diabetes is the most prevalent metabolic disease in developed countries and one that engenders - in addition to its high fatality - enormous health care costs. The physiological meaning of the ‘feel-good’ hormone serotonin in insulin-producing cells of the pancreas was not understood for more than 40 years but has finally been resolved by scientists of the Max Planck Institute of Molecular Genetics in Berlin. The researchers Diego J. Walther, Nils Paulmann and colleagues report in the current issue of PloS Biology, that a lack of serotonin in the pancreas causes diabetes. The interdisciplinary research team identified the underlying molecular and physiological mechanisms. The close interdisciplinary collaboration with Marjan Rupnik, head of the Institute of Physiology in Maribor, Slovenia, and a former group leader at the Max Planck Institute for Biophysical Chemistry, as well as the collaboration with Heidrun Fink, executive director of the Institute of Pharmacology and Toxicology of the School of Veterinary Medicine, Free University Berlin, was particularly instrumental to allowed untangling these findings (Paulmann et al., PloS Biology, October 27, 2009).
​

This quote: "When the serotonin levels are low like in serotonin-deficient mice, proper insulin secretion is hampered and blood glucose concentration rises to noxious levels after a meal, a hallmark of diabetes." I think implies that they are simply saying that low 5HT in pancreas allows higher levels of serum glucose, not necessarily the syndrome of diabetes. Sounds like a stress reaction in the gut that causes glucose to rise. Just wondering if this research going anywhere since 2009 in your research. Thanks again!

 

[haidut]

@haidut
Have you run across this research before?:
'Feel-good' hormone serotonin regulates blood sugar concentration

Diabetes is the most prevalent metabolic disease in developed countries and one that engenders - in addition to its high fatality - enormous health care costs. The physiological meaning of the ‘feel-good’ hormone serotonin in insulin-producing cells of the pancreas was not understood for more than 40 years but has finally been resolved by scientists of the Max Planck Institute of Molecular Genetics in Berlin. The researchers Diego J. Walther, Nils Paulmann and colleagues report in the current issue of PloS Biology, that a lack of serotonin in the pancreas causes diabetes. The interdisciplinary research team identified the underlying molecular and physiological mechanisms. The close interdisciplinary collaboration with Marjan Rupnik, head of the Institute of Physiology in Maribor, Slovenia, and a former group leader at the Max Planck Institute for Biophysical Chemistry, as well as the collaboration with Heidrun Fink, executive director of the Institute of Pharmacology and Toxicology of the School of Veterinary Medicine, Free University Berlin, was particularly instrumental to allowed untangling these findings (Paulmann et al., PloS Biology, October 27, 2009).
​

This quote: "When the serotonin levels are low like in serotonin-deficient mice, proper insulin secretion is hampered and blood glucose concentration rises to noxious levels after a meal, a hallmark of diabetes." I think implies that they are simply saying that low 5HT in pancreas allows higher levels of serum glucose, not necessarily the syndrome of diabetes. Sounds like a stress reaction in the gut that causes glucose to rise. Just wondering if this research going anywhere since 2009 in your research. Thanks again!

If this was true then using SSRI drugs would have been the perfect treatment for diabetes. Not only are they not, but SSRI are well known to cause diabetes.
Medscape: Medscape Access
Antidepressant use linked to type 2 diabetes in young adults

These mice models are not very reliable because they often use so-called knock-out models - i.e. animals genetically engineered to completely lack serotonin or specific serotonin "receptors". I would not expect such mutants to be healthy to start with and the complete lack of serotonin is probably not healthy for anybody. We are not arguing for the goodness of complete lack of serotonin, but what chronic excess would do.

 

[Motif]

So what's the best things I could do against higher serotonin?

I will start cypro in two days, but I think this won't be a good longterm solution

 

[InChristAlone]

So what's the best things I could do against higher serotonin?

I will start cypro in two days, but I think this won't be a good longterm solution

Cypro was the best crutch for me. And then you can move on to better things.

 

[Motif]

Better things like what?

And did cypro do. for you?

 

[A. squamosa]

@Janelle525 I'm also interested to know what you moved onto after cypro?
I am using cypro now (I'll be using it for no more than 2 weeks once I come off it), no more than 2mg once a day, and while I can tell it is having an effect (constipation, waking tired instead of alert, i.e., removal of stress-based energy), I can't really tell what else it is doing for me; regardless, I'd like to know how I can continue its beneficial effects once I come off it.

 

[TheBeard]

This study is presented as groundbreaking and unexpected but in fact big pharma has been quietly working on anti-serotonin therapy for obesity/diabetes for more than a decade. I think the importance of this study is the admission that serotonin causes obesity/diabetes in humans, as one of the authors says. Apparently, as the scientist says, the role of serotonin in these pathologies is well-known. Funny, the unsuspecting public never got the memo...But quietly and without much fanfare, pharma companies have started several trials with TPH inhibitors for treating obesity and diabetes, and many others are underway abroad where big pharma does not have to comply with so many regulations.
Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity

Anyways, I suppose the good news is that even hardcore dogmatics in mainstream medicine can change their mind and improve people's health as a result. Now, the study below talks about reducing gut serotonin as therapeutic and for most scientists this means some sort of inhibition of serotonin synthesis. However, since the main trigger of gut serotonin synthesis is endotoxin, perhaps something as simple as the 5-HT3 antagonist approach mentioned in this thread could work.
Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked

Unlike 5-HT3 antagonists, of which there are plenty and all are well tested, TPH inhibitors are much harder to come by and even older ones like Fenclonine do not really have much experimental safety track record. Furthermore, I have received reports from several people that even a BCAA/tyrosine combination seems to improve their digestion and help them lose weight, so there is hope that this can still be achieved with dietary serotonin restriction without the use of pharma drugs.

Augmented capacity for peripheral serotonin release in human obesity
https://medicalxpress.com/news/2018-03-obesity-trigger-human-gut.html
"...In a new development in gastrointestinal research, researchers from Flinders University, SAHMRI and the University of Adelaide have found more evidence that elevated concentrations of serotonin, the crucial neurotransmitter that chemically transmits messages to nerve cells in the body, is also linked to obesity. Only recently have researchers understood that this "gut serotonin" is actually bad for our metabolism, as it increases blood glucose and fat mass, thus endangering us of developing diabetes and obesity. The new research demonstrates for the first time in humans that this gut serotonin is doubled in obese individuals. This new insight now paves the way to try and find potential new treatments for obesity by focusing on the cells in our gut that produce this hormone. The South Australian researchers were part of a large international research team including University of Adelaide experts that found human obesity is characterised by an increased capacity to produce and release serotonin in the gut."

"...We know from a raft of recent high profile publications that gut-derived serotonin causes diabetes and obesity, but we didn't know if this was relevant to such disorders in humans. Our findings are the first work implicating serotonin as a driver of worsening obesity in humans," says Professor Keating. "Having established this, we can now focus on understanding why this happens, so we can develop methods to reduce circulating serotonin levels. These sorts of therapeutic outcomes are exactly why Pfizer decided to partner with us in this research area over the past four years." University of Adelaide Senior Research Fellow, Associate Professor Richard Young, says these findings also indicate that obese humans secrete excess serotonin from the upper gut at rest, as well as during a meal. "This has revealed new ways that we may be able to control the release of serotonin from within the gut, and in turn, further improve the outlook for people living with obesity", says senior co-author on the paper Associate Professor Young."

Everything is « official » until another study pops up to proove otherwise.

It was official that dairy was good for your bones, then it was official that it caused ostheoporosis and inflammation.
It was official that sugar was good for you, now we find it responsible for diabetes and cancer.
It was official that gluten-rich foods were a good source of fiber, now we know gluten is pro-inflammatory.

Let’s be humble and not title anything « it’s official »

 

[haidut]

Everything is « official » until another study pops up to proove otherwise.

It was official that dairy was good for your bones, then it was official that it caused ostheoporosis and inflammation.
It was official that sugar was good for you, now we find it responsible for diabetes and cancer.
It was official that gluten-rich foods were a good source of fiber, now we know gluten is pro-inflammatory.

Let’s be humble and not title anything « it’s official »

The "official" was referring to major medical journals (JAMA, NEJM, Nature, etc) publishing a study saying serotonin is detrimental to health. Up until a few years ago that topic was complete taboo and I know people who got their papers rejected because their papers stated serotonin can cause neurodegenerative disease. What wording would you suggest instead?

 

[TheBeard]

The "official" was referring to major medical journals (JAMA, NEJM, Nature, etc) publishing a study saying serotonin is detrimental to health. Up until a few years ago that topic was complete taboo and I know people who got their papers rejected because their papers stated serotonin can cause neurodegenerative disease. What wording would you suggest instead?

Something less sensational: serotonin causes diabetes and obesity in humans

 

[Mhouse]

Something less sensational: serotonin causes diabetes and obesity in humans

Well, that might not cover the message of the thread. The “it’s official” seems to serve to say that mainstream medicine has started to adopt (at least not reject) this view on serotonin.

 

[LCohen]

Dopamine is the answer for both obesity and serotonin dominance. Why ?

Because dopamine not only targets for some serotonin receptors. It directly antagonize all/overall serotonin.

Dopamine agonists also suppresses appetite. You feel satiated all the time.

Some dopamine agonist drugs have thermogenic, fat-burning effects. Bromocriptine is used for diabetes, weight loss purposes.

Cyproheptadine ? When it comes to weight answer is no for me. It's a powerful appetite stimulant, a H1 blocker, weak dopamine antagonist. You will definitely gain weight on Cyproheptadine.

But yes it's also powerful anti-serotonin drug. It's useful for Cushing's, inflammatory diseases. It has anti-cancer, anti-fibrotic effects.

 

[Arnold Grape]

Cypro was the best crutch for me. And then you can move on to better things.

Curious about this, too - better things for what, specifically?