L
Louisa
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Read this everyone..
Vitamin B-12 warning: Avoid cyanocobalamin, take only methylcobalamin
Vitamin B-12 warning: Avoid cyanocobalamin, take only methylcobalamin
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The uniqueness of active cobalamin absorption resides in an IF-mediated system of limited capacity that maximizes the bioavailability of ingested cobalamin, whether free or food-bound, while simultaneously preventing excess absorption, perhaps especially to exclude nonfunctional or even harmful corrinoid analogs.
More than 50% of the cobalamin in a typical meal will be absorbed actively if the IF system, which includes IF and its uptake system, is intact. However, IF cannot accommodate much more than 2 mcg cobalamin at a time (Table 27.2[*]). Larger doses, such as those found in many supplements, exceed the capacity of the IF system. The excess cobalamin then becomes dependent on passive, nonspecific absorption, which is much less efficient (1% to 2% of the dose is absorbed) even though it is nonsaturable and linearly related to the amount of cobalamin presented.
So the credit goes not only to him, but also to the authors of the book for condensing a lot of good information. The book is as big as burtlan's balls of steel.The estimated daily loss of 1 mcg cobalamin is minute when compared with the body stores of approximately 2500 mcg (17, 64). This large disparity explains why depletion of body stores takes years and why clinically apparent cobalamin deficiency, as opposed to SCCD [sub-clinical cobalamin deficiency], only infrequently arises because of poor dietary intake. Bioavailability approximates 50% at usual intake levels (see Table 27.2[*]), and this explains the recommended dietary allowance of 2.4 mcg.
Speaking of b12!
@tyw you recently mentioned the methylation support you use, and it didn't include b12. Would really appreciate if you could give the reason(s) for why. I noticed a source you are fond of has it recommended under Interventions (1) at the bottom - Aging, health and disease – view from the DNA Methylome | AGINGSCIENCES™ – Anti-Aging Firewalls™
Reported is a single case study of a dementia in an 85-year old white male with "normal" B12 values reversed with intermuscular B12 injections. A.S., an 85-year-old, lefthand dominant, white male with a 10-year history of controlled hypertension, presented with memory slippages and lethargy that developed gradually for 2 years.
The serum vitamin B12 level was 368 (pg/mL), which is well within normal range, and was found reliable on repeated analyses.
[Our] patterns of findings were inconsistent with an Alzheimer's dementia because of the intact frontal lobe functioning, but rather they were suggestive of a global/metabolically induced dementia. In addition, our previous NCAs [neurocognitive assessments] have demonstrated a similar pattern of results and deficits in four other geriatric patients treated successfully and reversed with intramuscular B12 , despite "normal" serum vitamin B12 levels.
With a working diagnosis of B12 deficiency, the patient received intramuscular [daily] supplementation [and his] mental status improved gradually. [..] Lethargy and cognitive slowing had disappeared, and he was now taking the initiative in conversation.
These reported NCA deficits have proved to be a consistent pattern in identifying four previous, similar cases of reversible (350-400 pg/mL) vitamin B12 dementias in our clinic.
As with other reports.l-3 this case supports the notion that mental manifestation of B12 deficiency can precede hematologic abnormalities. A IV-stage model of the development of B12 deficiency has suggested that myelin or other neurological damage can occur in the first two stages when B12 levels can still be within the "normal" range."
The current lower normal parameter limit of 200 pg/mL used in the United States is based on hematological criteria," and should not be accepted automatically when encountering a psychiatric/dementia-like disorder. In fact, the lower limits of vitamin B12 in Japan and some European countries are 500-550 pg/mL,7,8 which are based on neurological criteria.
A reassessment of United States normal serum vitamin B12 levels based on neurological criteria with age and gender norms may be warranted.
Deficiency of water-soluble vitamins, especially group B vitamins, is common in cirrhosis
Vitamin B12 deficiency is mainly related to the decrease of its liver reserves. Serum levels may be increased, but tissue levels are decreased.26 This deficiency is associated with anemia, glossitis and neurological symptoms.
What if there is insufficient cobalt in the soil(in that way even animals can't make enough B12), it's the cobalt that makes it special right ? (I have a suspicion that broiler feed and generic feed for animals don't contain that much cobalt,hence people have low levels despite eating meat) .A long time ago, I think it was year two (bp.), I went to an endocrinologist that had a specialization in nutrition to ask for a lab test to evaluate b12 levels.
- How can I help you?
- I want to check if my b12 levels are good.
- Ok, but why b12?
- I haven't been eating much meat lately.
- So..?
- What do you mean?
- What it has to do with the exam?
- Aren't meats the main sources of b12?
- Really? <looks away puzzled and paused> <resumes contemplation, opens his browser in front of me and checks> - No way, indeed!
- ??
And so I did the exam. As soon as the result was released I checked, the value was fine, within the acceptable range. "It must be in my head then".
The doctor asked me to return to his office. After arriving he checked the exam and replied: the value is fine, anything else that I can help you with? He was being paid by the insurance company for every return, regardless of the length of the visit.
It was the first time that I confirmed my suspicion that only a few doctors know what they're doing.
The lab considered deficiencies only values lower than 81pg/mL.
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Vitamin B12 in meat and dairy products. - PubMed - NCBI
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Speaking of Metallica, I'm not sure but I think that an excess of metals, especially heavy metals in soil interfere with cobalt incorporation, affecting animals later on.What if there is insufficient cobalt in the soil(in that way even animals can't make enough B12), it's the cobalt that makes it special right ? (I have a suspicion that broiler feed and generic feed for animals don't contain that much cobalt,hence people have low levels despite eating meat) .
WOW. Just wow. *shakes head*A long time ago, I went to an endocrinologist that had a specialization in nutrition to ask for a lab test to evaluate b12 levels.
- Aren't meats the main sources of b12?
- Really? <looks away puzzled and paused> <resumes contemplation, opens his browser in front of me and checks> - No way, indeed!