The "burning mouth" syndrome may be due to vitamin deficiencies, hypothyroidism

[haidut]

Just a quick post since I get a lot of emails about this issue, and apparently the rates have increased a lot since the pandemic began. According to the study below, this symptoms can be caused by insulin resistance, vitamin D/B6/B1 or zinc deficiencies, or hypothyroidism (high TSH). Looking at those issues, one immediately sees that they overlap to a great degree - any one of them may cause one or more of the others (e.g. hypothyroidism may cause insulin resistance or vitamin D deficiencies, and vice versa), though vitamin D deficiency is apparently the most common cause. Since the vitamin or zinc deficiencies are relatively easy to address, it may be worth trying some of those supplements if a person experiences the "burning mouth" issue for more than 2-3 days in a row, and a food/dietary reason has been excluded.

Tongue Can Indicate If You Are Low On The Sunshine Which Is Vitamin-D Nutrient

Isn’t it amazing that our tongue can tell us whether we are suffering from vitamin D deficiency or not? But this vitamin deficiency which our tongue indicates is often neglected by us and goes undiagnosed for years and more. That’s when the real problem starts. So if anyone has any of the...

interviewerpr.com

"...A study was scheduled by the Department of Dermatology, Mayo Clinic, Rochester which is based in the USA in the year 2017. “In patients with symptoms of Burning Mouth Syndrome (BMS), our results suggest it is reasonable to screen for fasting blood glucose, vitamin D (D2 and D3), vitamin B6, zinc, vitamin B1, and TSH. Deficiencies of vitamin B12 and folic acid were rare.” The study was titled: “Burning mouth syndrome: results of screening tests for vitamin and mineral deficiencies, thyroid hormone, and glucose levels-experience at Mayo Clinic over a decade”. Yet again a report was carried out by Express.co.uk, this burning pain or this sensation is mostly located in the lips or tongue, or in some the other cases it is more widespread in the whole of the mouth. One can also sense other symptoms including numbness, dryness, and an unpleasant taste. This sensation can make mealtimes very uncomfortable. But Burning Tongue Syndrome is not exclusively linked to Vitamin D deficiency and can also be caused by a variety of different vitamin and mineral deficiencies, such as vitamin B, iron, and zinc."

 

[Jing]

Vitamin b6 has got rid of burning pain on the roof of my mouth.

 

[haidut]

Vitamin b6 has got rid of burning pain on the roof of my mouth.

Great, thanks for sharing. Do you mind expanding a bit - i.e. what type, how much daily and for how long you used it before you saw an effect?

 

[Jing]

Great, thanks for sharing. Do you mind expanding a bit - i.e. what type, how much daily and for how long you used it before you saw an effect?

P5P, 90mg daily and noticed an effect next day was all gone after two days. 90mg all before bed I also find it helps me sleep better.

 

[aliml]

Inflammatory cytokines (IL-6, IL-1β, TNF-α) are associated with burning mouth syndrome.

A large dose of vitamin B6 (100 mg/day) suppresses inflammatory cytokines (that is, IL-6 and TNF-alpha).

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis | Request PDF

Request PDF | Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis | The purpose of this study was to investigate whether vitamin B(6) supplementation had a beneficial effect on inflammatory and immune responses in... | Find, read and cite all the...

researchgate.net

IL-6 Inhibitors​	IL-1beta Inhibitors​	TNF-alpha Inhibitors​
Top Ways to Inhibit IL-6​ Spices: Bay leaves [63], Black pepper [63], Nutmeg [63], Oregano [63], Sage [63] Resistant starch [64] Zinc [65] Magnesium [66] Probiotics: B. infantis [67], S. boulardii [68], L. casei [69], L. Salivarius [70] Trehalose [71, 72] Jasmine Tea/EGCG[73] Vitamin D3 [74] PQQ [75] Andrographis/Andrographolide [76] – Out of 20 plants tested, Andrographis inhibited IL-6 the most and was more potent than dexamethasone. (IC50= .74mcg/ml) Black Cumin Seed Oil/Thymoquinone [77] Curcumin [78, 79] Licorice [80] Fish oil/DHA [81] Fisetin [82] Cinnamon [63] /Sodium Benzoate Molecular hydrogen machine [83] Aspirin [84] Boswellia [85] Lithium[86] Hydroxytyrosol [87] Apigenin [63] Luteolin [88] Quercetin [63] Resveratrol (500 mg, with 5 g leucine) [79, 89] Red Yeast Rice/Lovastatin [90] Foods To Inhibit IL-6​ Positive emotions were associated with lower IL-6 (especially awe, wonder, and amazement) [118]. Calorie Restriction [119] Wim Hof Breathing/Meditation [120] Napping after sleep loss [121] Vegetables/Phytosterols [122] LLLT [123, 124, 125] Legumes [126] Nuts [127] Oat polyphenols [128] Mediterranean diet [129] Olive oil [130] Ancient wheat [131] Fish oil [132] Phytic acid [133] Blueberry [134] Music [135] Honey [136] Elemental diet in Crohn’s disease [137] Broccoli sprouts/Sulforaphane [138] Soy [139] Oats [140] Cashew [96] Spirulina [141] Stevia [142, 143] Garlic [144] (raw is better) Red raspberries [145] Jasmine Tea [146] Nutrients To Inhibit IL-6​ Vitamin B12 [92] Fish oil [147, 148] Magnesium [149] Chromium [150] Arginine [151] Histidine [152] Vitamin E [153] – rats fed oxidized oils. Hormones To Inhibit IL-6​ MSH [154] ACTH [154] Vitamin D3 [74] Progesterone [155] Testosterone [29] Ghrelin [156] Supplements To Inhibit IL-6​ Bile [157] Glycine [158] Inositol [159] Bromelain [160] Ginkgo [161] Sialic Acid [162, 163] Berberine[164] Elm bark [165] Apple polyphenols [166] Chinese Skullcap [167] Carnosine [168] LDN [169] Grape Seed Extract [170] Betulin/Chaga [171] Cocaine [172] Honokiol [173] Artemisinin [174] Baicalin [175] RLA (Lipoic Acid) [176] Lactoferrin [177] Mastic gum [178] Ashwagandha Alfalfa – potent [179] Caffeic acid (Chlorogenic acid has caffeic acid) [180] Ellagic acid [180] Fucoidan [181] Astaxanthin [182] Astragalus [183] Danshen [184] Dandelion [185] Genistein [186] Hesperidin [187] Tart Cherry [188] Vitamin E/Tocotrienols [189] Antler velvet [190] Quercetin [82] Rutin [82] Myricetin [82] Echinacea [191] Rosmarinic acid [192] Red clover [193] Bitter melon [194] Magnolol [195] Glutamine [196] Allegra/Fexofenadine [197] Metformin [198] MSM Chrysin [199] Electroacupuncture [200], Structured water [201], Mizolastine (antihistamine) [197], Oxymatrine [202], Methotrexate (drug) [203], Sumac [204], Perilla [205], Tibetan medicated-bath [206]. Pathways To Inhibit IL-6​ ACE inhibitors [105] PPARy STAT3 inhibitors [207]	Top Ways To Inhibit IL-1b​ Cod liver/Fish oil/DHA [90] Jasmine Tea/Tea Polyphenols [91] Kombucha/Lactic acid [92] Black Cumin Seed Oil [93]… not bad [94] Cinnamon/Sodium Benzoate Raw honey [95] Stevia [96, 97] Goldenberries [98] Trehalose [99, 100] LLLT [101] Fasting [56] (Increases IL-1Ra) Foods To Inhibit IL-1b​ Cyanidin-3-O-β-glucoside (C3G) – typical anthocyanin [122] – Found in many fruits. Ginger [106] – Has lectins, but was one of the most potent out of 20 medicinal plants [106]. Sulforaphane/Broccoli sprouts/Cruciferous Vegetables [123]. Anthocyanins (from red raspberries) [124]. Oat polyphenols [125] Astaxanthin in fish [126]. Betalain/Beets [127] Hormones To Inhibit IL-1b​ a-MSH [102] – Also lessens the stimulatory effects of IL-1b on the HPA axis [103]. ACTH [102] Testosterone [104] Ghrelin [105] Supplements To Inhibit IL-1b​ Andrographis [106] – Out of 20 plants, Andrographis inhibited IL-1b the most and was more potent than dexamethasone. PQQ [107] Fisetin [108] Gynostemma [109] Curcumin [68] – Powerful suppression in response to IMQ [110] Trans-Resveratrol 500mg +5g Leucine [111, 112] Luteolin [113] EGCG [114] – Powerful [115] Apigenin [116] Boswellia [117] Hydroxytyrosol [118] (not potent) Pterostilbene [119] (Strong… 30uM) Reishi [120] – Powerful L Plantarum [121] – for the gut especially. Bile [128] Vitamin A/Retinol [129] B-glucans [130] MDMA (Drug) [131] Autophagy – The natural breaking down of what is unnecessary in the body. Tart Cherry Extract [132] Sialic Acid [133] Berberine [134] Grape Seed Extract [135] Chinese Skullcap/Baicalin [136, 137] Ashwagandha (IL-1) Slippery elm [138] Rhodiola [139] Silymarin [140] Astragalus [141] Rosmarinic acid [142] Danshen/Salvia Miltiorrhiza [143] Magnolol [144] Echinacea [145], Cichoric acid (from Echinacea) [146] Mannose? [147] Rhubarb/Emodin (found in Resveratrol pills, Rhubarb, Aloe) [148] Atractylodes/Atractylenolide I (IL-1) Zinc (if deficient) [149] Alfalfa [150] Perilla [151], Rapamycin – longevity drug [152], Electroacupuncture (IL-1) [153], Mizolastine (antihistamine) (IL-1) [154], Canakinumab (drug). Pathways To Inhibit IL-1b​ PPARy (IL-1a) [155] ACE inhibitors (IL-1) [156]	Top Ways To Inhibit TNF-a​ Vagus nerve stimulation [92] Ketosis [93] Acute psychological stress [94] and Glucocorticoids/Cortisol [95] (not recommended) Calorie restriction [96] Yoga [97] Tai Chi [98] Wim Hof Breathing/Meditation [99] Cycling [98] Mediterranean diet [100] Elemental diet for lectin sensitive [101]. Napping after sleep loss [102]. Falling in love, having sex, nursing, and positive social encounters. All of these lead to increased oxytocin [103]. L Reuteri also increases oxytocin [104]. LLLT [105, 106, 107] Elemental diet [101]/ Lectin avoidance diet if lectin sensitive Fish Oil/DHA+EPA [108] Fasting [109] Exercise PQQ [110] Curcumin [111, 112] EGCG [113] Cinnamon/Sodium Benzoate [114, 115] Black Cumin Seed Oil [116] Rooibos [117] Carob [118] Nicotinamide Riboside NAD+ [119] Kombucha/Lactic acid [120] Hops (xanthohumol) [121] Foods To Inhibit TNF-a​ Sardines (the protein in it) [126] Cinnamon/Sodium Benzoate Nutritional Yeast/B-glucans [127, 128] – found in mushrooms. Stevia [129, 130] Honey [131] Chocolate /Coffee – PDE inhibitors such as xanthines, caffeine, and theophylline Trehalose [132, 133] Garlic [134] Fish Oil [135] Dates [136, 137] Blueberries/Berries/Cyanidin-3-O-β-glucoside (C3G) – typical anthocyanin found in blackcurrant pomace, European elderberry, red raspberries, plum, peach, lychee, and açaí [138]. Sulforaphane/Broccoli Sprouts/Cruciferous Veggies [139] Soy [140] Betalain/Beets [141] Kamut [142] Coriander [143] Tamarind [144] Slippery elm [145] Dandelion [146] Hormones To Inhibit TNF-a​ Cortisol [147] MSH [148] ACTH [148] Oxytocin [149] Adiponectin [150] Melatonin [151] Vitamin D3 [152] Progesterone (Pregnenolone converts to it) [153] Estrogen (Pregnenolone converts to it) [154] DHEA [155] Ghrelin [156] Supplements To Inhibit TNF-a​ Inositol [159, 160] – also see picture above Boswellia [161] Nicotinamide [119] EGCG [162] Hydroxytyrosol [163] Licorice [164], LicoA [165], Glycyrrhizin [166] Luteolin [167] Andrographolide [168] Fisetin [169] Resveratrol [170] Bile [171] Lactoferrin [172] Glycine [173] Chromium [174] Sialic Acid [175, 176] Arginine [177] Bromelain [178] Berberine [179, 160] Apple polyphenols [180] Silymarin [181] Honokiol [182] Chinese Skullcap [183]/Baicalin [184] Ginkgo [185] Hespderidin [186] Carnosine [187] Phytosterols [188] Tart Cherry [189] Astaxanthin [190] Astragalus [191] Probiotics/B. coagulans [192] Cat’s claw [193] Artemisinin [194] Carnitine [195] Genistein [196] Amla/Indian Gooseberry [197] CoQ10 [198] Magnolol [199] Echinacea [200] Chaga/Betulin [201] Bitter melon [202] Mastic gum [203] Oxymatrine [204] Red clover [205] Glucosamine [206] Quercetin [169] Rutin [169] Myricetin [169] Ashwagandha Chrysin [207] Mannose? [208] Forskolin [209] Molecular Hydrogen [210] Histidine [211] Antler velvet [212] Emodin [213]. Danshen [214]/TanshioneII [215] Agmatine + Zymosan [216] Mercury – Low levels [217] Mud therapy [218] Pathways To Inhibit TNF-a​ ACE inhibitors [91] PPARy [235] HDAC inhibitors (Butyrate) [236]

 

[Vajra]

... or from not washing your carrots

 

[LuckyCat]

Had this happen after starting synthroid. I’m someone who does not convert t4 to t3 very well - once I stopped, it (and many other bad symptoms) went away.

 

[golder]

Had this happen after starting synthroid. I’m someone who does not convert t4 to t3 very well - once I stopped, it (and many other bad symptoms) went away.

What do you do now? Just T3 only? Have you tried any ways to improve your T4 to T3 conversion?

 

[LuckyCat]

What do you do now? Just T3 only? Have you tried any ways to improve your T4 to T3 conversion?

I take the most t4 or NDT I can tolerate and add some t3. It took a long time to figure it out.

 

[SuperStressed]

This just happened to me for the first time ever. I woke up in the middle of the night feeling like my throat and mouth were on fire. It's not like acid reflux, it feels like your mouth is literally on fire. It went away and I fell back asleep. I actually forgot it happened until it just flared up again. Worrying stuff.

 

[SuperStressed]

This just happened to me for the first time ever. I woke up in the middle of the night feeling like my throat and mouth were on fire. It's not like acid reflux, it feels like your mouth is literally on fire. It went away and I fell back asleep. I actually forgot it happened until it just flared up again. Worrying stuff.

This went away and never came back, it was a very strange experience!

 

[I'm.No.One]

Surprised B12 isn't really being looked at here, deficiency is incredibly common since it's a major B used up by stress & burning lips/mouth is a primary symptom.

On top of that people with gut issues can't absorb it from food during digestion.

For me not a single B vitamin besides B12 did anything for my sudden burning lips/mouth/face, B12 knocked it out in less than a week sublingually.

Side note: ALL of the histamine issues I randomly developed went away and my temps are now perfect (thinking this is why thyroid never made a difference for me, it was just B12 deficiency and mimicking hypothyroid).

 

[Candeias]

For me it started after taking B2 in active form and B12, I think it's a B6 deficiency