It seems they may be used interchangeably/are synonyms.I also thought menatetrone was k2 ( mk4)
not menaquinone
I hope Imtaking the correct one
Menatetrenone vs Menaquinone - What's the difference?
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It seems they may be used interchangeably/are synonyms.I also thought menatetrone was k2 ( mk4)
not menaquinone
I hope Imtaking the correct one
No you didn't sound brusque, not at all! I've been known to panic at times too.No please never stop linking info,
I just got in abit of a panic about k2
and my response came across brusque.
I'm always very grateful for your input.
@Blossom
I just thought you probably didn't have your reading glasses on at the time. That's my excuse when I misspell something. Seriously though some of these words get a bit ridiculous when you're not a scientist.@Blossom
For all my research I can't even spell
The bloody word properly.
I've just disolved into manic
Brain mush.
Yeah but I need to be sure,I have clogged arteries.
I'm just fed up with all the confusion.
“MK-4 is taken up by our tissues very rapidly after we consume it. While it hasn’t been studied as carefully as MK-7, it may be less effective than MK-7 at reaching liver and bone but more effective at reaching most other tissues. This would make it better at protecting those tissues from calcium deposits and cancer development and supporting sex hormone production through its direct actions within our sex organs.”
View attachment 9216
https://chrismasterjohnphd.com/2016/12/09/the-ultimate-vitamin-k2-resource/
I believe all forms support blood clotting but.....from Masterjohn’s The Ultimate Vitamin K2 ResourceWould I still need to take k1 as I take aspirin
Or will menatetrenone cover normal coagulation.
I wonder why Mk7 is the go to, compared to mk8 or mk9I believe all forms support blood clotting but.....from Masterjohn’s The Ultimate Vitamin K2 Resource
MK-7 Supports Blood Clotting Better Than K1
MK-7 is not just three times better than K1 at reaching bone; it’s also five times better at supporting blood clotting (Schurgers, 2007). This may be because the greater fat-solubility of MK-7 makes it hold on more tightly to the membranes within liver cells, making it stay active in the liver much longer rather than being released and broken down (Shearer, 2008). The liver is where clotting proteins are made, so more extended activity in the liver would explain why MK-7 could better support blood clotting. If this is correct, other long-chain MKs such as MK-8 and MK-9 probably share this property as well.
From Protein Folding to Blood Coagulation: Menaquinone as a Metabolic Link between Bacteria and MammalsVit K2 in chronic high doses delivered at once are also a little concerning. It's more like a therapeutic approach and I have no idea how the body adapts to it when the person insists on elevated daily doses. I remember Tarmander experiencing some problems with it, I have the impression it's something slightly stressful.
Between K1, MK-4 and MK-7, K1 is the most saturated of them, and if I recall it correctly, the liver is its main target when absorbed and circulated in such form. Rayzord posted about vitamin A supplements being easily oxidized during digestion (plug), and perhaps the same occurs with K2 as vvell. In this regard, K1 will probably be more stable. It's also protective because if you consume enough greens, you'll have these quinones all throughout the entire digestive tract.
When you apply a K2 supplement topically, some will eventually reach the liver, but there won't be the normal distribution that occurs with digestion, in which nutrients first pass through the liver and only then reach other tissues. Since most products available contain different menaquinones, MK-4 is rapidly taken up by other tissues and the liver will get the other menaquinones and MK-4 possibly only when other tissues already have an excess of it.
I know there are trials with it to treat liver cancer but there are a lot of therapies that involve oxidative stress to restore respiration, something unnecessary or even slightly detri and mental for maintenance. I think plenty of greens and a little K2 is a safer approach. In foods these vitamins are protected, therefore they're more resistant to degradation before absorption.
Maybe 1.5 mg topically (Kuinone) 3x/day will work as well. 90 mg (30 mg 3x/day) was based on the osteoporosis study (ie, 45 mg / 45 kg or 1 mg/kg), your weight, and the amount in a megadose pill. 5 pills = 75 mg and wasn't quite enough.Slade what dosage were you running? I just purchased mk4 and plan to do 45 mg daily for this effect. @baccheion said to go 90, which is kinda expensive
I'm going to try 45 mg orally for a month, with LEF once a dayMaybe 1.5 mg topically (Kuinone) 3x/day will work as well. 90 mg (30 mg 3x/day) was based on the osteoporosis study (ie, 45 mg / 45 kg or 1 mg/kg), your weight, and the amount in a megadose pill. 5 pills = 75 mg and wasn't quite enough.
How long do others say it takes to notice widening?I'm going to try 45 mg orally for a month, with LEF once a day
I don't trust topical
I know @sladerunner69 said 5mg for a year, Ivysaur said almost immediately which is eh, a few women on here noticed it after a few months.How long do others say it takes to notice widening?
I know @sladerunner69 said 5mg for a year, Ivysaur said almost immediately which is eh, a few women on here noticed it after a few months.
A buddy of mine used it for 2 months along with a chewing gum and got results
I like your point about K1.I tried MK7 at around 80mcg every other day for maybe a week or two. I developed some odd stretch marks on my skin. I stopped taking it and after almost two months now it's basically gone away. No idea if cis or trans.
Been taking MK4 80mcg every day for a week or so and did notice the strange smooth teeth effect after a few days. There's like this slick sort of film covering the teeth. I feel like the saliva is every so slightly more viscous? This is all hard to quantify so take it all with a grain of salt. Downside I did develop a small ulcer in the mouth, not sure if related.
Given all the information on the various types of vitamin K, I speculate the ideal form that should be taken is K1, in fact, but I have not tested this. I believe the body is meant to convert the K1 to K2 MK4 and utilize it. If you take the MK4 directly, it is akin to taking preformed vitamin A or D which bypasses the body's natural regulatory processes for levels of these vitamins. In nature, preformed vitamin A and D is actually quite rare (how many people in ancient times spent their days supplementing nonsense like fermented cod liver oil?), and is almost certainly NOT how humans evolved to obtain the vitamins. A is meant to come from plants, and D is meant to come from sunlight exposure. This is made obvious by the fact that you can develop hypervitaminosis from A and D rich foods, but you cannot readily overdose on beta carotenes, or die rapidly from excessive sun exposure. In which case, I propose K1 is the same. It may be vitamin K1 and/or provitamin K2 MK4.