Swandattur
Member
Wow! There's just a lot of information and ideas that I will be cogitating on in this thread. This discussion helped things come together for me, and I will probably be waking up with new insights from this for a while.
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jyb said:Mittir said:RP mentioned in a recent radio interview that he gets sleep problem if he does not cook his liver with tons of fat. Chicken liver has way more iron than beef liver and excess iron can cause lots of other problems too.
Why does the liver need cooking with lots of fat?
I usually don't cook it much, the inside still being dark red, as I thought it would preserve nutrients. And also overcooked liver tastes even worse.
j. said:Rayser said:j. said:Rayser said:Swandattur - A friend of mine works in an emergency room and has to drive around with the ambulance every week for a night. He says they get calls about "heart attacks" and "strokes" all the time which turn out to be "panic attacks". You know how they treat them? Glucose intravenously.
I was one of those once. The first thing they measured was my blood sugar, and it was fine. So I think there can be other reasons.
I'm afraid some are really something else but I found that even at "normal blood sugar levels" or what the WHO calls normal you can have symptoms of hypoglycemia which can be reduced or disappear when you use a lot of sugar.
One of the things I did was I drank Pepsi, which has sugar (not the HFCS kind), and then it got much worse. Although I guess one could say the caffeine maybe caused that. I think there are gut issues that can result in panic attacks.
Ray Peat said:In the excessively sensitive condition produced by hypoglycemia, several things happen that contribute to the maladaptive exaggerated inflammatory response.
Adrenaline increases in hypoglycemia, and, if the adrenaline fails to convert glycogen into glucose, it will provide an alternative fuel by liberating free fatty acids from fat cells.
If the liberated fatty acids are unsaturated, they will cause serotonin to be secreted, and both serotonin and the unsaturated fatty acids will suppress mitochondrial respiration, exacerbating the hypoglycemia. They will stimulate the release of cytokines, activating a variety of immunological and inflammatory processes, and they will cause blood vessels to become leaky, creating edema and starting the first stages of fibrosis. Both adrenaline and serotonin will stimulate the release of cortisol, which mobilizes amino acids from tissues such as the large skeletal muscles. Those muscles contain a large amount of cysteine and tryptophan, which, among other effects, suppress the thyroid. The increased tryptophan, especially in the presence of free fatty acids, is likely to be converted into additional serotonin, since fatty acids release tryptophan from albumin, increasing its entry into the brain. Free fatty acids and increased serotonin reduce metabolic efficiency (leading to insulin resistance, for example) and promote an inflammatory state.
Fats in the blood-stream have easy access to the brain, and the unsaturated free fatty acids produce brain edema (Chan, et al., 1983, 1988). When brain edema is caused by vascular leakage, proteins that are normally excluded can enter. The stimulated, excited and fatigued brain exchanges glutamine for tryptophan, accelerating its uptake from the blood.
Rayser said:j. - I knew I'd read it somewhere ...
Ray Peat said:In the excessively sensitive condition produced by hypoglycemia, several things happen that contribute to the maladaptive exaggerated inflammatory response.
Adrenaline increases in hypoglycemia, and, if the adrenaline fails to convert glycogen into glucose, it will provide an alternative fuel by liberating free fatty acids from fat cells.
If the liberated fatty acids are unsaturated, they will cause serotonin to be secreted, and both serotonin and the unsaturated fatty acids will suppress mitochondrial respiration, exacerbating the hypoglycemia. They will stimulate the release of cytokines, activating a variety of immunological and inflammatory processes, and they will cause blood vessels to become leaky, creating edema and starting the first stages of fibrosis. Both adrenaline and serotonin will stimulate the release of cortisol, which mobilizes amino acids from tissues such as the large skeletal muscles. Those muscles contain a large amount of cysteine and tryptophan, which, among other effects, suppress the thyroid. The increased tryptophan, especially in the presence of free fatty acids, is likely to be converted into additional serotonin, since fatty acids release tryptophan from albumin, increasing its entry into the brain. Free fatty acids and increased serotonin reduce metabolic efficiency (leading to insulin resistance, for example) and promote an inflammatory state.
Fats in the blood-stream have easy access to the brain, and the unsaturated free fatty acids produce brain edema (Chan, et al., 1983, 1988). When brain edema is caused by vascular leakage, proteins that are normally excluded can enter. The stimulated, excited and fatigued brain exchanges glutamine for tryptophan, accelerating its uptake from the blood.
Swandattur said:Maybe your body for whatever reason interprets the blood sugar as low. I have often had hypoglycemic symptoms when my blood sugar was the same as other times when I would feel fine. Maybe problem gut bacteria could cause the body to make this seemingly wrong interpretation.
Swandattur said:4Peatssake: Another earlier doctor in that family was an explorer mostly known for an arctic expedition. He, along with other expedition members, were on a ship that got frozen in for two years, and he and some others lived by eating rats from the ship and finally trekking out on foot. They ran into some Eskimos who no doubt saved them by teaching them how to stay alive in the arctic. The explorer named Elisha Kent Kane looks in one picture a lot like my youngest son.
You are taking both aspirin and niacinamide, these two inhibits free fatty acids release from tissue. When you skip breakfast you are living off free fatty acid and free amino acids turning to sugars. This can be a possible explanation for this. I think with serious problem like this you need to consult a doc and get some blood works done.LoveBlood said:I've never had reactions to food like this, I could miss breakfast and be out doing stuff and not be phased etc.
Mittir said:You are taking both aspirin and niacinamide, these two inhibits free fatty acids release from tissue. When you skip breakfast you are living off free fatty acid and free amino acids turning to sugars. This can be a possible explanation for this. I think with serious problem like this you need to consult a doc and get some blood works done.LoveBlood said:I've never had reactions to food like this, I could miss breakfast and be out doing stuff and not be phased etc.
Mittir said:I am still bit confused. My guess is that when you are not taking aspirin and niacinamide it is easier to skip a meal and not have a problem. Because you are using free fatty acid storage from your tissue to keep you going. Were you taking aspirin and niacinamide before peat style diet? How long have you been supplementing aspirin and niacinamide and at what dose?
It may take some time for body to clear all those supplement's effect.