Succinic Acid Promotes Hypertrophy

[tastyfood]

@Hans would you say succinic acid should be taken with food so it's not hard on the stomach?

 

[Hans]

@Hans would you say succinic acid should be taken with food so it's not hard on the stomach?

That's how I take it. I haven't taken it on an empty stomach before so can't tell you the difference.

 

[ddjd]

Brad Marshall of fire-in-a-bottle website, discusses succinic acid here (start at 1h 50min):


View: https://youtu.be/UTjSE9gvW9U?t=6636

 

[Diogo]

Building new muscle is very energy intensive process and optimizing ATP will speed up the process.

Here is an in vivo study, in mice though, that show that succinic acid promoted hypertrophy and inhibited protein breakdown.

"In this paper, we firstly identified that succinate could significantly promote protein synthesis in vitroand in vivo, accompanished with activation of Akt/mTOR/S6 cascade and inhibition of FoxO3a."

"Succinate is the endogenous ligand for GPR91, which mediated the effect of succinate on muscle hypertrophy (24), protein deposition (25) and metabolism regulation (26). Both the mRNA and protein level of GPR91 are ubiquitously expressed in many tissues, including skeletal muscle (27), which indicates this receptor and its downstream signaling pathway might be involved in succinate induced skeletal hypertrophy. Once activated by succinate, GPR91 recruited Gαiprotein to inhibit cAMP production and increase intracellular Ca2+ (17). "

"It has been reported activation of GPR91 triggered [Ca2+]i elevation and subsequently, the activation of Erk (33)."

"In conclusion, our study demonstrated that succinate promoted skeletal muscle protein synthesis through Erk/Akt signaling pathway."

The dose was rather high, 150mg/kg and 300mg/kg, which would be 10.7mg/kg and 21.4mg/kg for humans. The big dose was more effective than the smaller dose.

Other agents that can increase ATP are pentadecanoic acid, inosine, ribose, magnesium, B1, B2, B3, fructose, methylene blue and palmitic acid just to name a few.

Hello Hans, shouldn´t someone on a high carb diet avoid both Palmitic and Pentadecanoic acid due to oxidation?

If supplementing Succinic acid and methylene blue should come in hand with a nice meal, should we wait past digestion to consume any of the fatty acids?

 

[Hans]

Hello Hans, shouldn´t someone on a high carb diet avoid both Palmitic and Pentadecanoic acid due to oxidation?

If supplementing Succinic acid and methylene blue should come in hand with a nice meal, should we wait past digestion to consume any of the fatty acids?

Not really unless you're in a surplus. But lots of exercise can help to offset that.

 

[Ainaga]

etc.