• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

Vitamin E Succinate Very Effective Against Liver Carcinoma ,acetate Form Increases It

Mauritio

Member
Joined
Feb 26, 2018
Messages
4,338
Very interesting study that shows Vitamin E succinate to decrease hepatocellular carcinoma by 77% ! It was actually caused/increased by vitamin E acetate .
I included the whole results section from the abstract ,because every point actually deserves it's own discussion .

Also vitamin A and D deficiency caused tumor increases . The tumors numbers increased by 6 fold ! Still let's me doubt the whole "Poison A+D " thing even more.

Next it confirms the detrimental effects that PUFA has! Simply replacing the soy in the diet with casein protein or dextrin sugar, reduced the carcinomas to almost nothing!
This is probably the mechanism of action of Vitamin E succinate as it protects from PUFA . Interesting that Vitamin E acetate doesnt do that .
It might also have to with the succinate they consumed which inhibits FFAs and is thus anti cancer .

@haidut actually posted a study showing that vitamin E acetate was able to prevent calcification, but he said that acetate form is of lower quality. Plus theres no reason the succinate form can't treat the calcification and as we saw in this study it is actually anti cancer as opposed to acetate. So if somebody tried to replicate the results of that study I would always go with vitmain E succinate instead of acetate.





"Elevated dietary tocopheryl acetate (E-Ac) caused a marked increase in liver size and in AfB1-induced HCCs in rainbow trout. 2.) Poor diets increased the HCC incidence. 3.) Elevated dietary tocopheryl succinate (E-Su) nearly eliminated HCC development in fish fed complete diets. Tocopheryl succinate in poor diets reduced HCCs by 77% compared to tocopheryl acetate diets. 4.) Trans-retinoic acid also reduced HCC incidence. 5.) Vitamins A and D deficiency caused tumor increases but had no effect on liver size. 6.) The use of casein and dextrin in the place of soybean textured vegetable protein, in poor diets nearly eliminated the HCC risk. 7.) Trout sera showed all three vitamin forms; free α-tocopherol (E-OH), tocopheryl acetate (E-Ac) and tocopheryl succinate (E-Su), from diets containing any of these vitamin analogues, suggesting both de-esterification and trans-esterification. 8.) E-Su is discussed in the light of an anti-cancer agent that is non toxic to normal tissue but that cohorts to it are needed."

"
HCC numbers increased by 10 fold in 10 months. As early as 6 weeks on the diets the livers were becoming pale and enlarged. At 6 months on the highest E-Ac diets (16.25 gm/Kg diet) livers were twice as large as the controls. Liver enlargement and jaundice occurred whether aflatoxin was in the diet or not."

Hepatocellular carcinomas are promoted by tocopheryl acetate but eliminated by tocopheryl succinate - ScienceDirect
 
Last edited:
Joined
Apr 29, 2020
Messages
853
Age
60
Location
United Kingdom
Amazing, I have used succinate E in the past and I think i'll get back on it, thanks :D
 

Mauritio

Member
Thread starter
Joined
Feb 26, 2018
Messages
4,338
Joined
Apr 29, 2020
Messages
853
Age
60
Location
United Kingdom
Dietary RRR-α-tocopherol succinate attenuates lipopolysaccharide-induced inflammatory cytokines secretion in broiler chicks | British Journal of Nutrition | Cambridge Core

Vitmain E succinate is anti-endotoxin! It reduces many markers of inflammation that are triggered by endotoxin /LPS .
Interestingly they tested vitamin E acetate again ,but only said that succinate was effective. My guess is because acetate just wasn't effective ,as in the OP study .

@yerrag Have you seen the above?, your thoughts??
 

yerrag

Member
Joined
Mar 29, 2016
Messages
9,718
Location
Manila
@yerrag Have you seen the above?, your thoughts??

Hmm. I wonder why the broiler chicks have high LPS. Is it coming from the feed they're eating?

I guess it would help to use vitamin E succinate to deal with the high LPS condition, but I also would want to lower LPS production in the system as well.
 

Mauritio

Member
Thread starter
Joined
Feb 26, 2018
Messages
4,338
Hmm. I wonder why the broiler chicks have high LPS. Is it coming from the feed they're eating?

I guess it would help to use vitamin E succinate to deal with the high LPS condition, but I also would want to lower LPS production in the system as well.
They actually feed them endotoxin (250mcgs/kg body weight, in this case)!
That's a normal scientific practice to induce generel inflammation and test how anti-inflammatory a substance is . That's how bad endotoxin is lol
 

yerrag

Member
Joined
Mar 29, 2016
Messages
9,718
Location
Manila
They actually feed them endotoxin !
That's a normal scientific practice to induce generel inflammation and test how anti-inflammatory a substance is . That's how bad endotoxin is lol
I see. I was afraid my comment would betray I didn't read the article. And it sure did lol
 

Recoen

Member
Joined
Jun 8, 2020
Messages
608
What brand do you all like? How do you like vit E succinate compared to another vitamin E like tocovit?
This is also assuming your body can use the succinate.
 

GenericName86

Member
Joined
Jun 30, 2018
Messages
312
Also interested to hear what brands you guys are trying. I had the Nutricology brand few years ago not sure if it's any good though
 

Mauritio

Member
Thread starter
Joined
Feb 26, 2018
Messages
4,338
I am currently still using the nutricology brand and its the only one that gives me desired results without toxic /allergic effects.
I still liked tocovit but I had a slight allergic reaction ,like swelling of the upper eye lid (just a little) increased puffiness and eye bags I liked how I felt ,but these symptoms mean that it doesnt agree with my body long term. I dont have these symptoms with vitamin e succinate!

I ordered this one , its super cheap and has no other ingridients. Also they make it super easy for you if you want to request a coa .

Acid Succinate Powder (Vitamin E)
 

Recoen

Member
Joined
Jun 8, 2020
Messages
608
I am currently still using the nutricology brand and its the only one that gives me desired results without toxic /allergic effects.
I still liked tocovit but I had a slight allergic reaction ,like swelling of the upper eye lid (just a little) increased puffiness and eye bags I liked how I felt ,but these symptoms mean that it doesnt agree with my body long term. I dont have these symptoms with vitamin e succinate!

I ordered this one , its super cheap and has no other ingridients. Also they make it super easy for you if you want to request a coa .

Acid Succinate Powder (Vitamin E)
Thank you! Will you please share how you like the pure bulk vs nutricology after trying it? Are you going to mix it with olive oil and apply topically or take orally?
 

ddjd

Member
Joined
Jul 13, 2014
Messages
5,135
a lot of brands offer a "dry" version of their vitamin E line, and that is almost always made from succinate
 

Similar threads

Top