Dietary Methionine Restriction Improves Thyroid Function

aguilaroja

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Here is evidence for improved thyroid function in lab animals when restricting methionine in diet. The paper mentions vegan diet as an example of a low methionine approach. Increased gelatin intake is another possibility.

@haidut recently further discussed metabolic benefits of keeping methionine intake proportionally low.
Gbolduev Q And A - Non Peat

Dietary methionine restriction regulated energy and protein homeostasis by improving thyroid function in high fat diet mice. - PubMed - NCBI

"Methionine-restricted diets (MRD) show an integrated series of beneficial health effects, including improving insulin sensitivity, limiting fat deposition, and decreasing oxidative stress, and inflammation responses."
"MRD significantly increased energy expenditure (e.g. fatty acid oxidation, glycolysis, and tricarboxylic acid cycle metabolism), regulated protein homeostasis, improved gut microbiota functions, prevented thyroid dysfunction, increased plasma thyroxine and triiodothyronine levels, decreased plasma thyroid stimulating hormone levels, increased type 2 deiodinase (DIO2) activity, and up-regulated mRNA and protein expression levels of DIO2 and thyroid hormone receptor α1 in the skeletal muscle. These results suggest that MRD can improve metabolic disorders induced by HFD, and especially regulate energy and protein homeostasis likely through improved thyroid function."

"...MRD promoted TCA metabolism. Succinate, citrate, and α-ketoglutarate are important intermediates of TCA. We found that the MRD mice showed increased plasma citrate levels, and urinary succinate and α-ketoglutarate levels compared with the HFD mice, thus indicating that MRD promoted TCA metabolism. Consistent with this conclusion, skeletal muscle glycogen and ATP levels were increased in MRD mice. These findings are in agreement with previous studies showing that MRD increased glucose uptake and glycolytic ATP production in the mice skeletal muscle.

"MRD mice showed significantly increased plasma T3 and T4, and decreased TSH levels, compared with HFD mice, thus implying that MRD promoted energy metabolism. These results are consistent with the up-regulated mRNA expression levels of TPO, NIS, TGB, and TSHR, which are genes specific for the thyroid function38, in the thyroid tissues of MRD mice compared to the HFD mice. In addition, through histopathological analysis, we found that H&E staining distinctly showed that the average follicle area is decreased in the thyroid tissues from the MRD mice. Therefore, all evidence strongly suggested that MRD improved the morphological structure and function of thyroid in mice.
"The increased average heat production and ambulatory activity, and decreased body weight also support that MRD increased energy expenditure. Interestingly, we found that MRD significantly increased food and energy intake, but decreased body weight gain in mice, implying that MRD reduced fat deposition without calorie restriction."

"MRD significantly reduced gastrocnemius weight, soleus weight, and the average fibre area of gastrocnemius tissues (same as the CON group), but increased skeletal muscle index, combine with no histopathological abnormalities were obvious in the gastrocnemius tissues compared with the HFD mice. These results also suggested that MRD regulated protein catabolism and synthesis in the skeletal muscle."

Meat physiology, stress, and degenerative physiology.
"Tryptophan and methionine contribute to the formation of polyamines, so gelatin, which lacks those amino acids and is soothing to the intestine, should be a regular part of the diet."

Gelatin, stress, longevity
"It happens that gelatin is a protein which contains no tryptophan, and only small amounts of cysteine, methionine, and histidine. Using gelatin as a major dietary protein is an easy way to restrict the amino acids that are associated with many of the problems of aging."
 

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