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overview Gastroparesis: A turning point in understanding and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493126/
"More recently, human studies have shown loss of macrophages with anti-inflammatory phenotype (CD206 positive, M2 or alternatively activated macrophages) and increased expression of genes associated with pro-inflammatory macrophages on transcriptomic analysis of full thickness biopsies.
This is complemented by animal model studies of diabetic gastroparesis where an altered macrophage activation was shown to mediate injury to ICC likely through paracrine mediators. Additionally, CSF1op/op mice lacking macrophages were protected from development of gastroparesis in spite of having diabetes suggesting an essential role for immune cells in development of delayed gastric emptying. Immune mediated mechanisms likely play a critical role in pathogenesis of gastroparesis."
So if that theory is correct she could try getting more anti-inflammatory type macrophages instead of the inflammatory type that could be worsening the gastroparesis.
something that does this is baking soda / bicarbonate soda. but is a risk in her case due to acidity lowering effect. would definitely have to be taken away from food at least.
baking soda shifts spleen macrophages from m1 pro-inflammatory to m2 anti-inflammatory, at 2 grams Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells
& worth a look into more things that have this effect to try that approach
for general gastric motility increase / a prokinetic Naringin should be something for this. not sure about naringenin but naringin should do this in humans ~500mg. and has a good safety profile for a try. tho annoyingly there is another study showing the opposite (i think?) but cant find the full paper to see if they were tested individually. Naringin exhibits in vivo prokinetic activity via activation of ghrelin receptor in gastrointestinal motility dysfunction rats - PubMed
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493126/
"More recently, human studies have shown loss of macrophages with anti-inflammatory phenotype (CD206 positive, M2 or alternatively activated macrophages) and increased expression of genes associated with pro-inflammatory macrophages on transcriptomic analysis of full thickness biopsies.
This is complemented by animal model studies of diabetic gastroparesis where an altered macrophage activation was shown to mediate injury to ICC likely through paracrine mediators. Additionally, CSF1op/op mice lacking macrophages were protected from development of gastroparesis in spite of having diabetes suggesting an essential role for immune cells in development of delayed gastric emptying. Immune mediated mechanisms likely play a critical role in pathogenesis of gastroparesis."
So if that theory is correct she could try getting more anti-inflammatory type macrophages instead of the inflammatory type that could be worsening the gastroparesis.
something that does this is baking soda / bicarbonate soda. but is a risk in her case due to acidity lowering effect. would definitely have to be taken away from food at least.
baking soda shifts spleen macrophages from m1 pro-inflammatory to m2 anti-inflammatory, at 2 grams Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells
& worth a look into more things that have this effect to try that approach
for general gastric motility increase / a prokinetic Naringin should be something for this. not sure about naringenin but naringin should do this in humans ~500mg. and has a good safety profile for a try. tho annoyingly there is another study showing the opposite (i think?) but cant find the full paper to see if they were tested individually. Naringin exhibits in vivo prokinetic activity via activation of ghrelin receptor in gastrointestinal motility dysfunction rats - PubMed
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Thank you
Last edited:
mostlylurking
Member
thiamine gastroparesis Archives - Hormones Matter
www.hormonesmatter.com
In addition to TTFD, there is also a sublingual thiamine supplement that could help. The point here is that these two do not require OK intestinal function whereas thiamine hcl is absorbed in the small intestine so is less likely to work for this problem.
EMF Mitigation - Flush Niacin - Big 5 Minerals
