Amazoniac
Member
Members that are crafting a beautiful coral reef in the intestines with the aid of eggshells,
Here's a simple study that looked at the association between constipation, elevated PTH and excess calcium in the blood, finding that it's actually the excess calcium that correlates well with constipation:
http://www.europeanreview.org/wp/wp-content/uploads/1163.pdf
"We noted that in patients with serum calcium level > 11.5 mg/dL, C [constipation] was present in 61.5% of the cases vs. 9.5% in subjects with a value of ≤11.5 mg/dL (χ2=15.75; p < 0.001) (Figure 2)."
"In both cases of patients with hyperparathyroidism, it was observed that the average value of the serum calcium level was significantly higher in patients with C as opposed to those without C."
"It has been reported in the literature that also in neoplasia-associated hypercalcemia, the greater the average serum calcium value, the higher the prevalence of C. The symptom can, in fact, have a frequency of 69% for an average level of calcemia over 12 mg/dL 21."
"On the other hand, in PHPT [Primary Hyperparathyroidism] almost all of the metabolic parameters indicating a major severity of the disease (increase in parathyroid hormone, decrease in phosphoremia, increase in serum alkaline phosphatase, increase in 24hr urinary calcium) are associated with an increase in the frequency of C."
"However, in some studies it is documented how parathyroidectomy reduces the level of calcemia and the prevalence of C of about 15% (1,3), reconfirming the fundamental role of calcium in initiating C."
"The results of our study demonstrate that:
The actual prevalence of C in primary PHPT, while high, is not significantly different from that observed in a control population;
A decreasing trend in the predominance of C with respect to past case studies is evident due to the prevalence, in recent years, of asymptomatic and/or “mild” forms of the disease;
The presence of C is correlated with the degree of hypercalcemia and the overall metabolic picture of PHPT; so it may suggest that C is associated with the severity of the disease rather than with the diagnosis of PHPT per se."
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http://www.amjmed.com/article/0002-9343(94)90330-1/
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Serum vitamin D and parathormone (PTH) concentrations as predictors of the development and severity of diabetic retinopathy
An Ancestral Perspective on Vitamin D Status, Part 2: Why Low 25(OH)D Could Indicate a Deficiency of Calcium Instead of Vitamin D - Weston A Price
"If our blood level of calcium drops for any reason — for example, if we aren’t consuming or absorbing enough calcium from our food — our endocrine system quickly launches a systematic program to bring that level back to normal (1). Our parathyroid glands ramp up their production of parathyroid hormone, which sends a signal to our kidneys to ramp up their conversion of 25(OH)D to calcitriol, the most active form of vitamin D. Calcitriol then increases serum calcium in two ways: preventing loss of calcium in the urine and feces, and extracting calcium from bone."
Here's a simple study that looked at the association between constipation, elevated PTH and excess calcium in the blood, finding that it's actually the excess calcium that correlates well with constipation:
http://www.europeanreview.org/wp/wp-content/uploads/1163.pdf
"We noted that in patients with serum calcium level > 11.5 mg/dL, C [constipation] was present in 61.5% of the cases vs. 9.5% in subjects with a value of ≤11.5 mg/dL (χ2=15.75; p < 0.001) (Figure 2)."
"In both cases of patients with hyperparathyroidism, it was observed that the average value of the serum calcium level was significantly higher in patients with C as opposed to those without C."
"It has been reported in the literature that also in neoplasia-associated hypercalcemia, the greater the average serum calcium value, the higher the prevalence of C. The symptom can, in fact, have a frequency of 69% for an average level of calcemia over 12 mg/dL 21."
"On the other hand, in PHPT [Primary Hyperparathyroidism] almost all of the metabolic parameters indicating a major severity of the disease (increase in parathyroid hormone, decrease in phosphoremia, increase in serum alkaline phosphatase, increase in 24hr urinary calcium) are associated with an increase in the frequency of C."
"However, in some studies it is documented how parathyroidectomy reduces the level of calcemia and the prevalence of C of about 15% (1,3), reconfirming the fundamental role of calcium in initiating C."
"The results of our study demonstrate that:
The actual prevalence of C in primary PHPT, while high, is not significantly different from that observed in a control population;
A decreasing trend in the predominance of C with respect to past case studies is evident due to the prevalence, in recent years, of asymptomatic and/or “mild” forms of the disease;
The presence of C is correlated with the degree of hypercalcemia and the overall metabolic picture of PHPT; so it may suggest that C is associated with the severity of the disease rather than with the diagnosis of PHPT per se."
--
http://www.amjmed.com/article/0002-9343(94)90330-1/
--
Serum vitamin D and parathormone (PTH) concentrations as predictors of the development and severity of diabetic retinopathy
An Ancestral Perspective on Vitamin D Status, Part 2: Why Low 25(OH)D Could Indicate a Deficiency of Calcium Instead of Vitamin D - Weston A Price
"If our blood level of calcium drops for any reason — for example, if we aren’t consuming or absorbing enough calcium from our food — our endocrine system quickly launches a systematic program to bring that level back to normal (1). Our parathyroid glands ramp up their production of parathyroid hormone, which sends a signal to our kidneys to ramp up their conversion of 25(OH)D to calcitriol, the most active form of vitamin D. Calcitriol then increases serum calcium in two ways: preventing loss of calcium in the urine and feces, and extracting calcium from bone."