The Effects Of Vitamin D Supplementation On Thyroid Function In Hypothyroid Patients: A Randomized,

Lucas

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The Effects of Vitamin D Supplementation on Thyroid Function in Hypothyroid Patients: A Randomized, Double-blind, Placebo-controlled Trial

Abstract
Background:
Data on the effects of vitamin D supplementation on thyroid function in hypothyroid patients are scarce.

Objective:
This study was done to evaluate the effects of vitamin D supplementation on thyroid function in hypothyroid patients.

Material and Methods:
This randomized double-blind, placebo-controlled trial was conducted on 201 hypothyroid patients aged 20–60 years old. Subjects were randomly assigned into two groups to intake either 50,000 IU vitamin D supplements (n = 102) or placebo (n = 99) weekly for 12 weeks. Markers of related with thyroid function were assessed at first and 12 weeks after the intervention.

Results:
After 12 weeks of intervention, compared to the placebo, vitamin D supplementation resulted in significant increases in serum 25-hydroxyvitamin D (+26.5 ± 11.6 vs. 0.0 ± 0.0 ng/mL, P < 0.001) and calcium (+0.4 ± 0.7 vs. 0.1 ± 0.6 mg/dL, P = 0.002), and a significant decrease in serum thyroid-stimulating hormone (TSH) levels (−0.4 ± 0.6 vs. +0.1 ± 2.0 μIU/mL, P = 0.02). A trend towards a greater decrease in serum parathyroid hormone (PTH) levels was observed in vitamin D group compared to placebo group (−3.8 vs. +1.9, P = 0.07). We did not observe any significant changes in serum T3, T4, alkaline phosphatase (ALP) and albumin levels following supplementation of vitamin D compared with the placebo.

Conclusion:
Overall, the current study demonstrated that vitamin D supplementation among hypothyroid patients for 12 weeks improved serum TSH and calcium concentrations compared with the placebo, but it did not alter serum T3, T4, ALP, PTH, and albumin levels.
 

Lewis Acid

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Mar 26, 2019
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This part is pretty important: A trend towards a greater decrease in serum parathyroid hormone (PTH) levels was observed in vitamin D group.
 
Joined
Dec 18, 2018
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The Effects of Vitamin D Supplementation on Thyroid Function in Hypothyroid Patients: A Randomized, Double-blind, Placebo-controlled Trial

Abstract
Background:
Data on the effects of vitamin D supplementation on thyroid function in hypothyroid patients are scarce.

Objective:
This study was done to evaluate the effects of vitamin D supplementation on thyroid function in hypothyroid patients.

Material and Methods:
This randomized double-blind, placebo-controlled trial was conducted on 201 hypothyroid patients aged 20–60 years old. Subjects were randomly assigned into two groups to intake either 50,000 IU vitamin D supplements (n = 102) or placebo (n = 99) weekly for 12 weeks. Markers of related with thyroid function were assessed at first and 12 weeks after the intervention.

Results:
After 12 weeks of intervention, compared to the placebo, vitamin D supplementation resulted in significant increases in serum 25-hydroxyvitamin D (+26.5 ± 11.6 vs. 0.0 ± 0.0 ng/mL, P < 0.001) and calcium (+0.4 ± 0.7 vs. 0.1 ± 0.6 mg/dL, P = 0.002), and a significant decrease in serum thyroid-stimulating hormone (TSH) levels (−0.4 ± 0.6 vs. +0.1 ± 2.0 μIU/mL, P = 0.02). A trend towards a greater decrease in serum parathyroid hormone (PTH) levels was observed in vitamin D group compared to placebo group (−3.8 vs. +1.9, P = 0.07). We did not observe any significant changes in serum T3, T4, alkaline phosphatase (ALP) and albumin levels following supplementation of vitamin D compared with the placebo.

Conclusion:
Overall, the current study demonstrated that vitamin D supplementation among hypothyroid patients for 12 weeks improved serum TSH and calcium concentrations compared with the placebo, but it did not alter serum T3, T4, ALP, PTH, and albumin levels.

PTH reduction is canonical,the absence showing that the error lies in the weekly dosing regimen.The D is all sequestered in Bodyfat-storage,and the low amount administered cant overcome this resistance.Over 50% had severe Deficiency as defined by the Conductors as lower than 20ng/ml.Subjects only gained around 25ng/ml on top of that,i have a hunch that it also took too long of a time to even reach these very modest levels,they didnt do a Bolus-Dose.Their 12weeks of observation time is thus too short and not in accordance to the expected and affirmed observational Window of 12weeks Observation,via slow onset of observable action via neglect of Bolus dosing.
 
Last edited:

zarrin77

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May 12, 2015
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San Diego, CA
Unfortunately, the TSH drop of 2.6 -> 2.2 isn’t much at all, and the T3 didn’t go up at all.

I like the drop in PTH, but it seems like vitamin A gets much more meaningful results for thyroid function:
The Effect of Vitamin A Supplementation on Thyroid Function in Premenopausal Women - PubMed

(They used a high dose. OA is vitamin A group, OP is placebo.)
0431BBAC-8FD9-41F5-B040-10BC2F91C797.jpeg

The issue I have with high dose vitamin A is that there is rodent evidence that it increases oxidative stress in the muscles as well as inhibits the beneficial adaptations that come from exercise:
https://www.researchgate.net/public..._and_HSP70_in_Skeletal_Muscle_of_Trained_Rats
 
Last edited:
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