Ashwagandha For Subclinical Hypothyroid

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I took it few years ago for a while. At first i loved how it made me feel warm and relaxed but after a couple of weeks i felt like i was in a dream all the time or something. Weird brain fog.
 

Constatine

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I took it few years ago for a while. At first i loved how it made me feel warm and relaxed but after a couple of weeks i felt like i was in a dream all the time or something. Weird brain fog.
Me too. An effect I consistently get from anything that raises serotonin.
 

BibleBeliever

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Me too. An effect I consistently get from anything that raises serotonin.
Any other effects that are sure signs of increased serotonin?
I decided to have some yesterday/today; havn't had any in maybe a year?
The first noticable effect was extraordinary arousal; so I used that energy for a very good workout. Many wrestler bridges forwards, backwards, bride presses, dive bomber push ups, sprints, jump rope and on and on.

I noticed a great increase in muscular stamina. Metabolism stimulated greater than usual and thus hunger. Muscular pump much higher.

Did not notice any irritability or agitation.

Consumed with jamaican ginger beer; ginger being anti-serotonin.

I had 2 grams of the powder. 2 grams a few hours later because I felt so good. Many of the studies were on 5 grams; divided into 2.5 grams twice per day; showing a huge decrease in cortisol l and a high boost in testosterone.

Is it possible the brain fog you speak of is simply a strong cortisol reduction; i.e lack of stress causes dream-like relaxation? Or are there methods to tell that it definitely is serotonin?
 

Constatine

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Any other effects that are sure signs of increased serotonin?
I decided to have some yesterday/today; havn't had any in maybe a year?
The first noticable effect was extraordinary arousal; so I used that energy for a very good workout. Many wrestler bridges forwards, backwards, bride presses, dive bomber push ups, sprints, jump rope and on and on.

I noticed a great increase in muscular stamina. Metabolism stimulated greater than usual and thus hunger. Muscular pump much higher.

Did not notice any irritability or agitation.

Consumed with jamaican ginger beer; ginger being anti-serotonin.

I had 2 grams of the powder. 2 grams a few hours later because I felt so good. Many of the studies were on 5 grams; divided into 2.5 grams twice per day; showing a huge decrease in cortisol l and a high boost in testosterone.

Is it possible the brain fog you speak of is simply a strong cortisol reduction; i.e lack of stress causes dream-like relaxation? Or are there methods to tell that it definitely is serotonin?
I am very sensitive to the effects of any serotonin agonist as I get a migraine and altered perception. I definitely get this from ashwagandha extracts like ksm-66 but not necessarily the root powder. Nevertheless I think ashwagandha is a great herb with an incredible amount of research to back it up. But for me more powerful extracts are not better.
 

Frankdee20

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Yeah, see I don't know how to assess your brain fog issues, specifically that it's from Serotonin agonism. Ashwaganda effects a lot of neural circuitry, it attenuates 5ht1a, augments GABA/Glycine, blocks the acetylcholinesterase enzyme, hits the Thyroid, attenuates cortisol, maybe augments 5ht2a. I just don't know what is attributable to what myself.
 

Frankdee20

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Even SJW isn't strictly a Serotonin herb, a lot of herbs hit different systems. Even Valerian, known for its effects on GAD, and GABA, does hit specific Serotonin receptors, good ones though.
 

Frankdee20

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We can't always completely block this ***t, and whose to say complete eradication is the ideal way to go.
 

DaveFoster

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Even SJW isn't strictly a Serotonin herb, a lot of herbs hit different systems.
I'd argue that SJW's hit the system, and they're very serotonergic.

maxresdefault.jpg
 

Frankdee20

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I'd argue that SJW's hit the system, and they're very serotonergic.

maxresdefault.jpg

Yes, SJW is primarily a Serotoninergic, but seems to have other activity as well. I don't know through which mechanism, be it MAO inhibition, cytochrome P450, reuptake, etc., but my point is a lot of herbs act on more than one neurotransmitter.
 

Frankdee20

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Like Nicotine for example, primarily acetylcholine agonism, but I've seen mechanism of action effect other systems via MAO inhibition.
 

Nokoni

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Frankdee20

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Okay, it's established that SJW is a serotoninergic, yes, and Judas ratted to Romans while Jesus slept.
 

Frankdee20

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So classify Ashwaganda then, please, be my guest.
 

Frankdee20

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Don't say it's a Serotoninergic primarily.
 

Frankdee20

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A lot of systems that SJW herb seems to hit huh ?
 

Frankdee20

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What's that look, SJW seems to have multiple systemic effects, well I'll be damned !
 
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