haidut

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As many of you know arterial stiffness is one of the main signs of CVD and contributes significantly to both elevations of blood pressure (BP) and actual ischemic events in brain/heart. According to official guidelines, arterial stiffness cannot be reversed once it sets in, and the only recourse is managing the risk of heart attacks and strokes through the use of BP lowering drugs.
However, in Asian countries vitamin K is often used off-label to reduce arterial stiffness and a few smaller human trials in USA have so far confirmed those results.
This new study shows that vitamin D, even when used in quite reasonable doses of 600 IU - 4,000 IU daily, dose-dependently reduced arterial stiffness in just 4 months. I suspect a combination of vitamin D and K would be even more effective.
@aguilaroja @Travis @Koveras @Amazoniac @Sheila

Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial

"...Vitamin D3 supplementation demonstrated a dose-response increase in serum 25(OH)D concentrations between groups (P<0.01). A significant downward linear trend was observed for carotid-femoral PWV (P<0.01), as the mean changes in carotid-femoral PWV across the four treatment groups were 0.13 m/s (95% CI: -0.24, 0.51 m/s) for placebo, 0.02 m/s (95% CI: -0.34, 0.38 m/s) for 600 IU/day group, -0.11 m/s (95% CI: -0.50, 0.27 m/s) for the 2,000 IU/day group, and -0.70 m/s (95% CI: -1.07, -0.32 m/s) for the 4,000 IU/day group. Findings were similar for carotid-radial PWV (P = 0.03), as the mean changes in carotid-radial PWV across the four treatment groups were 0.24 m/s (95% CI: -0.45, 0.92 m/s) for placebo, 0.09 m/s (95% CI: -0.54, 0.73 m/s) for 600 IU/day group, -0.57 m/s (95% CI: -1.20, 0.07 m/s) for the 2,000 IU/day group, and -0.61 m/s (95% CI: -1.25, 0.02 m/s) for the 4,000 IU/day group. Conclusion: Arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner in overweight African Americans with vitamin D deficiency."

"...To our knowledge, this is the first randomized controlled trial regarding dose-ranging vitamin D supplementation on measures of arterial stiffness in overweight African-Americans with vitamin D deficiency. The key finding from this study was that arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner. It is hypothesized that vitamin D deficiency is linked to greater arterial stiffness, suggesting that increasing vitamin D intake may improve arterial stiffness[15]. Few randomized clinical trials, to date, have assessed the effect of vitamin D supplementation on arterial stiffness measured by PWV."
 

Koveras

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Joined
Dec 17, 2015
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719
As many of you know arterial stiffness is one of the main signs of CVD and contributes significantly to both elevations of blood pressure (BP) and actual ischemic events in brain/heart. According to official guidelines, arterial stiffness cannot be reversed once it sets in, and the only recourse is managing the risk of heart attacks and strokes through the use of BP lowering drugs.
However, in Asian countries vitamin K is often used off-label to reduce arterial stiffness and a few smaller human trials in USA have so far confirmed those results.
This new study shows that vitamin D, even when used in quite reasonable doses of 600 IU - 4,000 IU daily, dose-dependently reduced arterial stiffness in just 4 months. I suspect a combination of vitamin D and K would be even more effective.
@aguilaroja @Travis @Koveras @Amazoniac @Sheila

Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial

"...Vitamin D3 supplementation demonstrated a dose-response increase in serum 25(OH)D concentrations between groups (P<0.01). A significant downward linear trend was observed for carotid-femoral PWV (P<0.01), as the mean changes in carotid-femoral PWV across the four treatment groups were 0.13 m/s (95% CI: -0.24, 0.51 m/s) for placebo, 0.02 m/s (95% CI: -0.34, 0.38 m/s) for 600 IU/day group, -0.11 m/s (95% CI: -0.50, 0.27 m/s) for the 2,000 IU/day group, and -0.70 m/s (95% CI: -1.07, -0.32 m/s) for the 4,000 IU/day group. Findings were similar for carotid-radial PWV (P = 0.03), as the mean changes in carotid-radial PWV across the four treatment groups were 0.24 m/s (95% CI: -0.45, 0.92 m/s) for placebo, 0.09 m/s (95% CI: -0.54, 0.73 m/s) for 600 IU/day group, -0.57 m/s (95% CI: -1.20, 0.07 m/s) for the 2,000 IU/day group, and -0.61 m/s (95% CI: -1.25, 0.02 m/s) for the 4,000 IU/day group. Conclusion: Arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner in overweight African Americans with vitamin D deficiency."

"...To our knowledge, this is the first randomized controlled trial regarding dose-ranging vitamin D supplementation on measures of arterial stiffness in overweight African-Americans with vitamin D deficiency. The key finding from this study was that arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner. It is hypothesized that vitamin D deficiency is linked to greater arterial stiffness, suggesting that increasing vitamin D intake may improve arterial stiffness[15]. Few randomized clinical trials, to date, have assessed the effect of vitamin D supplementation on arterial stiffness measured by PWV."

J Nutr Biochem. 2017 Aug;46:83-89. doi: 10.1016/j.jnutbio.2017.04.010. Epub 2017 Apr 22.
Synergistic effect of low K and D vitamin status on arterial stiffness in a general population.
Mayer O Jr1, Seidlerová J2, Wohlfahrt P3, Filipovský J2, Cífková R3, Černá V4, Kučerová A4, Pešta M4, Fuchsová R5, Topolčan O5, Jardon KMC6, Drummen NEA6, Vermeer C6.

Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix γ-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay. In a subsample of 431 subjects without chronic disease or pharmacotherapy, we detected rs2228570 polymorphism for the vitamin D receptor. After adjustment for confounders, aPWV was independently associated with both factors: dp-ucMGP [β-coefficient(S.E.M.)=13.91(4.87); P=.004] and 25-OH-D3 [0.624(0.28); P=.027]. In a further analysis, we divided subjects according to dp-ucMGP and 25-OH-D3 quartiles, resulting in 16 subgroups. The highest aPWV had subjects in the top quartile of dp-ucMGP plus bottom quartile of 25-OH-D3 (i.e., in those with insufficient status of both vitamin K and vitamin D), while the lowest aPVW had subjects in the bottom quartile of dp-ucMGP plus top quartile of 25-OH-D3 [9.8 (SD2.6) versus 6.6 (SD1.6) m/s; P<.0001]. When we compared these extreme groups of vitamin K and D status, the adjusted odds ratio for aPWV≥9.3 m/s was 6.83 (95% CI:1.95-20.9). The aPWV was also significantly higher among subjects bearing the GG genotype of rs2228570, but only in those with a concomitantly poor vitamin K status. In conclusion, we confirmed substantial interaction of insufficient K and D vitamin status in terms of increased aortic stiffness.
 

haidut

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J Nutr Biochem. 2017 Aug;46:83-89. doi: 10.1016/j.jnutbio.2017.04.010. Epub 2017 Apr 22.
Synergistic effect of low K and D vitamin status on arterial stiffness in a general population.
Mayer O Jr1, Seidlerová J2, Wohlfahrt P3, Filipovský J2, Cífková R3, Černá V4, Kučerová A4, Pešta M4, Fuchsová R5, Topolčan O5, Jardon KMC6, Drummen NEA6, Vermeer C6.

Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix γ-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay. In a subsample of 431 subjects without chronic disease or pharmacotherapy, we detected rs2228570 polymorphism for the vitamin D receptor. After adjustment for confounders, aPWV was independently associated with both factors: dp-ucMGP [β-coefficient(S.E.M.)=13.91(4.87); P=.004] and 25-OH-D3 [0.624(0.28); P=.027]. In a further analysis, we divided subjects according to dp-ucMGP and 25-OH-D3 quartiles, resulting in 16 subgroups. The highest aPWV had subjects in the top quartile of dp-ucMGP plus bottom quartile of 25-OH-D3 (i.e., in those with insufficient status of both vitamin K and vitamin D), while the lowest aPVW had subjects in the bottom quartile of dp-ucMGP plus top quartile of 25-OH-D3 [9.8 (SD2.6) versus 6.6 (SD1.6) m/s; P<.0001]. When we compared these extreme groups of vitamin K and D status, the adjusted odds ratio for aPWV≥9.3 m/s was 6.83 (95% CI:1.95-20.9). The aPWV was also significantly higher among subjects bearing the GG genotype of rs2228570, but only in those with a concomitantly poor vitamin K status. In conclusion, we confirmed substantial interaction of insufficient K and D vitamin status in terms of increased aortic stiffness.

Thanks. No wonder then that vitamin K lowers blood pressure as Peat said. There was so much hating over at Peatarian.com over his comments on vitamin K and blood pressure. The effects of vitamin D on BP have been known for a while but the mechanism is officially considered "unknown".
Vitamin D "as Good As Drugs" In Lowering Blood Pressure
 

GAF

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Not knowing the above, but only hoping, was the reason I applied calcirol to my temples and forehead. My thought was that maybe that could improve temporal arteritis and increase blood flow to scalp and brain.

Now, I think I will add a few vit D drops to the carotid artery area too.

The effect of applying to temple/forehead has been marked increase in wakefulness after lunch and later. No crashes. Maybe I am getting better blood flow up top.
 
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