from Peat's latest newsletter, Jan 2016: Nitric oxide, aging, and
adaptation--the Procrustean adaptogen
I think this speaks to nitric oxygen being one of the mechanisms by which chronic undereating (fuel deficiency) reduces thyroid metabolism:
And IIUC, this may link it with some other degenerative conditions too:
adaptation--the Procrustean adaptogen
Ray Peat said:The stresses of a harsh environment that make
early reproduction advantageous, or that require
accelerated tissue renewal, also favor epigenetic
adaptations that reduce energy demands. It has been
known for about 50 years that starvation during
pregnancy reduces not only the metabolic capacity
of the first generation, but of several following
generations. For a species, this transgenerational
effect is analogous to hibernation or estivation in an
individual, reducing metabolic needs to match the
diminished environmental resources.
I think this speaks to nitric oxygen being one of the mechanisms by which chronic undereating (fuel deficiency) reduces thyroid metabolism:
Ray Peat said:Since the metabolic rate must be in balance
with the availability of fuel, the thyroid hormone,
which directly activates the respiratory enzymes, is
especially important. Just as it wouldn't be possible
for an animal to hibernate in a hyperthyroid state, a
basic mechanism for dealing with stress in
non-hibernators is to lower the production of
thyroid hormone. Nitric oxide blocks the formation
of thyroid hormone in response to thyroid stimulating
hormone (Bazzara, et al., 2007). Oxygen deprivation
(Giusti, et al., 2008) and hypothyroidism
(Franco, et al., 2006) block energy production by
increasing NOS in the mitochondria.
And IIUC, this may link it with some other degenerative conditions too:
Ray Peat said:When cells convert glucose to lactate even
in the presence of oxygen, it's called "aerobic
glycolysis," and this is the condition that Otto
Warburg recognized as the basic feature of cancer.
Nitric oxide, by blocking the oxidation of glucose,
creates aerobic glycolysis. The amyloid protein
that accumulates in Alzheimer's disease promotes
aerobic glycolysis. Recent studies have discussed
the importance of reductive stress for the development
of Alzheimer's disease.