Niacinamide Long Term Use

GmC

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Mar 19, 2019
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Good afternoon everyone.

Just a small question about Niacinamide.
I've been using Niacinamide 150 mg daily, 50mg at breakfast, 50mg at lunch and 50mg dinner.

Is this the recommended daily dosage for long term use ? Is safe to use Niacinamide long term ?

Thank you so much.

G.C
 

Hans

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Aug 24, 2017
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2,874
Good afternoon everyone.

Just a small question about Niacinamide.
I've been using Niacinamide 150 mg daily, 50mg at breakfast, 50mg at lunch and 50mg dinner.

Is this the recommended daily dosage for long term use ? Is safe to use Niacinamide long term ?

Thank you so much.

G.C
Yes that is a pretty good dose. Peat said somewhere that about 100mg three times daily is a good dose. Haidut mentioned that 500mg can probably be taken daily due to being so safe.
 

berk

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Dec 28, 2019
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why you use Niacinamide?
 

Kunstruct

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Sep 6, 2018
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Does it work anti anxiety for you in that 3 doses per day? Would you say it works every day, or overall you are better with niacinamide rather than no niacinamide?
 

GmC

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Mar 19, 2019
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Does it work anti anxiety for you in that 3 doses per day? Would you say it works every day, or overall you are better with niacinamide rather than no niacinamide?

Few moments ago I read that Haidut uses 1500mg in the morning and 1500 mg at evening.
Since I started using this protocol ( 50 mg X 3 a day ) I feel better more relaxed, with much more patience for my child for example.Those persistent thoughts also disappear.
That's why I was asking about long term use, because last week when I stopped using Niacinamide ( I start using Niacinamide 1 month ago, 50 mg 3X daily ) I noticed that my anxiety increased.
And because I was diagnosed with reactive Hypoglycemia, I'm afraid that Niacinamide can cause more harm than good with prolonged use.
One strange side effect that Niacinamide give, are my feet temperature.
When I take Niacinamide my feet temperature are nice and warm, but I feel them like they were cold... it's a very odd feeling.
I touch with my hands to feel the temperature of my feet and they are perfectly warm ( not very hot ) but the feeling that my brain receives is like they were slightly cold... it's hard to explain.
Other than that, it work fine.
Maybe one day I will try Haidut protocol ( 1500 mg twice daily )

G.C
 
Last edited:

Orangeyouglad

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Jun 24, 2019
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Few moments ago I read that Haidut uses 1500mg in the morning and 1500 mg at evening.
Since I started using this protocol ( 50 mg X 3 a day ) I feel better more relaxed, with much more patience for my child for example.Those persistent thoughts also disappear.
That's why I was asking about long term use, because last week when I stopped using Niacinamide ( I start using Niacinamide 1 month ago, 50 mg 3X daily ) I noticed that my anxiety increased.
And because I was diagnosed with reactive Hypoglycemia, I'm afraid that Niacinamide can cause more harm than good with prolonged use.
One strange side effect that Niacinamide give, are my feet temperature.
When I take Niacinamide my feet temperature are nice and warm, but I feel them like they were cold... it's a very odd feeling.
I touch with my hands to feel the temperature of my feet and they are perfectly warm ( not very hot ) but the feeling that my brain receives is like they were slightly cold... it's hard to explain.
Other than that, it work fine.
Maybe one day I will try Haidut protocol ( 1500 mg twice daily )

G.C

It's crazy, but I'm the reverse of this. When I take Niacinimide I get angry and irritable. I always want to smoke/have a drink to take the edge off. I've had to take very small doses.

I'm wondering why it works for some and not others. I also wonder if it has anything to do with methylation as B vitamins seem tricky for me.
 

Hans

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Aug 24, 2017
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It's crazy, but I'm the reverse of this. When I take Niacinimide I get angry and irritable. I always want to smoke/have a drink to take the edge off. I've had to take very small doses.

I'm wondering why it works for some and not others. I also wonder if it has anything to do with methylation as B vitamins seem tricky for me.
I also think it has to do with methylation. Overmethylators seem to benefit the most from this (as niacinamide quenches methyl donors) and undermethylators might not, possibly giving symptoms you experience.
 

Orangeyouglad

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Jun 24, 2019
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I also think it has to do with methylation. Overmethylators seem to benefit the most from this (as niacinamide quenches methyl donors) and undermethylators might not, possibly giving symptoms you experience.

There seems to be some debate as to if Niacinimide quenches methyl donors or just Niacin. Either way, I'm still trying to figure out which I am, as I have inverse reactions to things that should help Over methylators, but have all the signs of an over methylator.
 

Hans

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There seems to be some debate as to if Niacinimide quenches methyl donors or just Niacin. Either way, I'm still trying to figure out which I am, as I have inverse reactions to things that should help Over methylators, but have all the signs of an over methylator.
It might not quench methyl donors but it is metabolized through methylation and can can increase homocysteine and increase catecholamine.

Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives. - PubMed - NCBI
"This study demonstrated that excess nicotinamide might deplete the labile methyl pool, increase Hcy generation and inhibit catecholamine degradation"
 

SOMO

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Mar 27, 2018
Messages
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I am also interested in this. I'm suffering from some (likely gut issue induced) skin and scalp issues and I noticed a increase in symptoms upon starting Niacinamide at 200mg/day.

When I first used Niacinamide, it gave me a horrible chicken-pox like rash on my neck and hips.

The skin became red and blotchy, but also very dry and slightly itchy.
 
Joined
Jun 23, 2020
Messages
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When I first used Niacinamide, it gave me a horrible chicken-pox like rash on my neck and hips.

The skin became red and blotchy, but also very dry and slightly itchy.

Why do you think that was, and what did you do about it?
 

Frankdee20

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Jul 13, 2017
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Location
Sun Coast, USA
It's crazy, but I'm the reverse of this. When I take Niacinimide I get angry and irritable. I always want to smoke/have a drink to take the edge off. I've had to take very small doses.

I'm wondering why it works for some and not others. I also wonder if it has anything to do with methylation as B vitamins seem tricky for me.

Dude, it will use up all of your sugar reserves, and when I first started this, I’d get so irritated but that was because I learned I must use food and sugars with it
 

SOMO

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Joined
Mar 27, 2018
Messages
853
Why do you think that was, and what did you do about it?

I think it was PUFA being excreted and it caused a prostaglandin storm basically.

I just put lotion on it and did not use B3 for a year after that lol.
 
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