Niacinamide: Safe Upper Limit?

Discussion in 'B3/Niacinamide' started by zanolachino, Nov 9, 2015.

  1. zanolachino

    zanolachino Member

    Apr 25, 2013
    In theory, niacinamide ought to be just what I need. I am trying to:

    1. Kick-start my metabolism back into burning sugar after years stuck in a very sick, low-energy, carbohydrate-intolerant state

    2. Address chronic nervous system agitation and insomnia

    For a few weeks now I have been taking 2g niacinamide twice per day for a total of 4g daily. It seems to be helping me tolerate at least a little more sugar, and one longstanding health issue (an "autoimmune" skin condition) is improving.

    Significantly, however, this dosage of niacinamide has no sedative or anxiolytic effect on me whatsoever.

    I am inclined to see if taking more will bring more benefit. Specifically, I would be delighted to arrive at a dose that noticeably calms my nervous system and helps me sleep (as niacinamide is supposed to do).

    But since I am already taking a fairly large daily dose, I would like to ask:

    Does anyone see danger in pushing the dosage higher and higher? Is there an argument for an upper limit?

    Also, are there other nutrients which might be in specific danger of depletion with long-term high-dose niacinamide use?
  2. Brian

    Brian Member

    Jun 8, 2014
    I've never dosed niacinamide that high and I don't think there is a benefit to going extremely high unless in some kind of experimental treatment. Something else might be missing in your system.

    What else are you supplementing? B1, B6 and B7 go well with niacinamide and assist in carb metabolism and mitochondrial function. Aspirin also compliments niacinamide and lowers the required dose of both to lower free fatty acids.

    I associate deep relaxation with parasympathetic nervous system activity. In part from magnesium stores being high and calcium being properly moved out of soft tissue into bone. So vitamin A, D, K, and sufficient tissue progesterone play a role with that too.
  3. BobbyDukes

    BobbyDukes Member

    Jan 6, 2015
    I become fairly tolerant to it pretty quickly. I can take 5-10g and sit there wide awake :shock:

    Initially though, the sedative effects were pretty pronounced (despite my pessimism, due to my previous abuse of GABAergics).

    I was hoping it was going to benefit my insomnia problem, but it hasn't even made a dent. It's a cool supplement on paper though, and I would take it (in sensible doses) on the advice of Dr Peat, if I ever remembered to take it (lol).

    If I take it very occasionally, it can have a sleep inducing effect. But everyday, and it doesn't do anything (even with lots of sugar).
  4. aguilaroja

    aguilaroja Member

    Jul 24, 2013
    Before increasing the amount of niacinamide, it might be interesting to use the same daily total amount but dividing into more frequent doses.

    Brian's point is also well taken that if the range of several grams or more of niacinamide per day is reached, finding other restorative factors may have a higher yield than increasing niacinamide.

    The 20th century physician who probably had the most direct experience with niacinamide was William Kaufman. He recommended niacinamide in practice for more than half a century, I think. I don't recall Kaufman using much more than 4000 mg total per day, ev

    He found that in effectively treating osteoarthritis, that more frequent dosing was helpful:

    "It has been found in the treatment of joint dysfunction that the manner in which 
    the daily dosage of niacinamide is divided has an important bearing on the therapeutic results achieved; e.g., 300 mg niacinamide given three times daily (900 mg/24 hours) is inferior in its therapeutic action to 150 mg niacinamide administered every 3 hours for 6 daily doses (900 mg/24 hours)."
    "Kaufman's findings were both plain and elegant. The greater the stiffness, the more frequent the doses. Severely crippled arthritic patients needed up to a total of 4,000 mg/day. Divided into 10 doses per day, in one to three months, patients could now get out of their chair, or bed."

    It is understood that osteoarthritis is not the concern here, and that it is more involved to use frequent dosing. Still, the guidance of Kaufman's long experience is worth thinking about.

    There's been interest for years in topical niacinamide (nicotinamide) for improving skin conditions, for instance:
    Topical nicotinamide for seborrheic dermatitis: an open randomized study.
    Fabbrocini G1, Cantelli M, Monfrecola G.
    J Dermatolog Treat. 2014 Jun;25(3):241-5. doi: 10.3109/09546634.2013.814754. Epub 2013 Jul 5.

    Of course, niacinamide is one component of haidut's Solban formulation. (I know haidut only from this forum and have no financial connection in raising this point) ... f=3&t=5830

    There are many posts on this forum about niacinamide experiences, research and effects.
  5. Makrosky

    Makrosky Member

    Oct 5, 2014
  6. Giraffe

    Giraffe Member

    Jun 20, 2015
    See this topic.
  7. OP

    zanolachino Member

    Apr 25, 2013
    Thanks to everyone who responded so far.

    I should have mentioned that I have been taking other B vitamins together with the niacinamide, and it may well be the whole package that has led to the modest improvements I have noticed. Specifically:


    B1 (thiamin mononitrate) 250mg
    B1 (allithiamine) 50mg
    B2 (R5P) 36.5mg
    B3 (niacinamide) 2g
    B6 (P5P) 20mg
    biotin 8mg


    B1 (thiamin mononitrate) 500mg
    B3 (niacinamide) 2g
    B5 500mg
    pantethine 450mg

    My reason for separating the biotin and B5 is that I remember reading that they compete for absorption.

    I also eat liver and oysters regularly and take a sublingual B12 (both hydroxocobalamin and adenosylcobalamin) on occasion. (For what it is worth, I have discovered the hard way that methylcobalamin and methylfolate make things go haywire, but these are not generally recommended around here, anyway.)

    Aspirin is tricky for me. It seems to have some positive effects, but it also clearly exacerbates my longstanding tinnitus. I just posted something about this here.

    There's no question that, from a Peat perspective, my diet remains too high in fat and too low in carbohydrate. Even with all of this niacinamide, B1, biotin, and so on, I would have to imagine that the Randle cycle is preventing proper sugar metabolism.

    The problem is, every time I have tried to shift this balance in the past, no matter how gradually, very severe blood sugar problems ensued. Low-carb was the only thing that kept blood sugar stable, even as low-carb created more and more problems of its own. I am hoping that this B vitamin regimen will be the key to escaping this Catch-22.

    I am also trying to increase caffeine, though I am not very tolerant. An experiment with methylene blue may be called for.

    I welcome additional thoughts, particularly from anyone who was actually stuck in the Warburg quicksand and managed to escape.
  8. blob69

    blob69 Member

    Nov 6, 2015
    Zanolachino, reading through your posts makes me think you might have a thyroid issue. Autoimmune skin condition, hypoglycemia/inability to tolerate carbs, low energy... Broda Barnes comes to mind immediately! :) Have you ever tried a thyroid supplement?

    Also, I think Ray Peat stated once that aspirin intolerance can go away when people sort out their thyroid.
  9. ecstatichamster

    ecstatichamster Member

    Nov 21, 2015
    Niacinamide seems to drive up the need for more sugar. It is easy to get hypoglycemic taking it without lots of sugar.
  10. tara

    tara Member

    Mar 29, 2014
    Seems likely.
    How did you go about it?
    What happened?

    Have you got measurements from monitoring temps and pulse?
  11. marikay

    marikay Guest

    I second this. I can barely handle 50mgs of niacinamide without a boatload of sugar. Any more than that amount of niacinamide or any less than 50 grams of sugar at the same time, and I get a massive headache.