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Now ALL of this pathway can be aborted with the appropriate use of NAC- and it operates by maintaining glutathione levels."These events include: (1) CYP metabolism to a reactive metabolite which depletes glutathione and covalently binds to proteins; (2) loss of glutathione with an increased formation of reactive oxygen and nitrogen species in hepatocytes undergoing necrotic changes; (3) increased oxidative stress, associated with alterations in calcium homeostasis and initiation of signal transduction responses, causing mitochondrial permeability transition; (4) mitochondrial permeability transition occurring with additional oxidative stress, loss of mitochondrial membrane potential, and loss of the ability of the mitochondria to synthesize ATP; and (5) loss of ATP which leads to necrosis"
The effect of N-acetylcysteine (NAC) on human cognition - A systematic review.
Abstract
Oxidative stress, neuroinflammation and neurogenesis are commonly implicated as cognitive modulators across a range of disorders. N-acetylcysteine (NAC) is a glutathione precursor with potent antioxidant, pro-neurogenesis and anti-inflammatory properties and a favourable safety profile. A systematic review of the literature specifically examining the effect of NAC administration on human cognition revealed twelve suitable articles for inclusion: four examining Alzheimer's disease; three examining healthy participants; two examining physical trauma; one examining bipolar disorder, one examining schizophrenia, and one examining ketamine-induced psychosis. Heterogeneity of studies, insufficiently powered studies, infrequency of cognition as a primary outcome, heterogeneous methodologies, formulations, co-administered treatments, administration regimes, and assessment confounded the drawing of firm conclusions. The available data suggested statistically significant cognitive improvements following NAC treatment, though the paucity of NAC-specific research makes it difficult to determine if this effect is meaningful. While NAC may have a positive cognitive effect in a variety of contexts; larger, targeted studies are warranted, specifically evaluating its role in other clinical disorders with cognitive sequelae resulting from oxidative stress and neuroinflammation.
I used to take NAC but also stopped taking it. It made me feel hypothyroid. I feel better without it.I got ill two days ago. Also, I started to take NAC 600 mg on that day(What a terrible coincidence). After two dosage, I stopped because I have seen somethings like “antioxidants supresses immune system” and “After using NAC, I got very ill”. Today is the 3rd day and I’m having weird feeling on my ears. Like pressure or a pain, but I’m not able to explain exactly. I had never been feel something like this before.
I will look if this will pass. I hope that I didn’t cause something serious with only just 2 doses of nac.
This alone is probably a good reason not to take itReddit seems to love it lol
Yeah but most new hype is met with people responding positively to it. Same with vegan, keto etc. They swear they never felt this good beforeEverywhere I read about it, people seem to experience massive positive effects from it.