May need higher dose of glycine (10g)?

[ReSTART]

Anybody seen this study?

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis

Collagen synthesis is severely diminished in osteoarthritis; thus, enhancing it may help the regeneration of cartilage. This requires large amounts of glycine, proline and lysine. Previous works of our group have shown that glycine is an essential amino ...

www.ncbi.nlm.nih.gov

Collagen hydrolysate has 33% glycine residues (25% of its mass), so 10 g of hydrolysate (the daily dose used) means 2.5 g of glycine, which is insufficient for the metabolic needs. It may produce a slight improvement, but better results could be achieved with a daily dose of 10 g of glycine which we are proposing here. On the other hand, gelatin or collagen hydrolysate are not advantageous as proline or lysine sources because their hydroxylated forms, which means about 30-50% of these amino acid residues (Barnes et al. 1974), are useless for reutilization. Thus, although results with collagen hydrolysate may be moderate, they are an indication of the glycine needed to propitiate cartilage regeneration.