Magnesium Sulfate And Chloride Inhibits Aldosterone

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Magnesium ion: a possible physiological regulator of aldosterone production. - PubMed - NCBI

Life Sci. 1989;44(20):1483-9.
Magnesium ion: a possible physiological regulator of aldosterone production.
Atarashi K1, Matsuoka H, Takagi M, Sugimoto T.

"Both magnesium sulphate (MgSO4) and magnesium chloride (MgCl2) (0 to 2 mM) decreased aldosterone production in a dose-dependent manner. In comparison with magnesium-free medium, 2 mM MgSO4 inhibited aldosterone production by 73% and MgCl2 by 65%. In addition, MgSO4 showed an inhibitory effect on aldosterone production stimulated by angiotensin II (10pM to 10nM), whereas it had no significant effect on aldosterone production due to ACTH stimulation (10pM to 10nM). These data suggest that magnesium has an inhibitory action on aldosterone production in vitro and may be a physiological regulator of aldosterone production."
 
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