Low Dose Niacinamide Prevents NAFLD / Cirrhosis

Discussion in 'Scientific Studies' started by haidut, Oct 15, 2015.

  1. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    The study used an animal model that is genetically engineered to develop liver fibrosis (cirrhosis) . The human equivalent dose of niacinamide was only 3mg/kg and study duration was 6 weeks. Niacinamide not only fully prevented liver fibrosis but also lowered all markers of liver damage to the levels of normal controls. Finally, niacinamide prevented liver fat accumulation which is another way of saying that low dose niacinamide may be an effective treatment for NAFLD.
    So, the next time your doctor tells you that niacinamide is bad for your liver (as Wikipedia claims) present the doctor with this study.

    Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

    "...Summing up, these results indicate that deletion of GNMT is associated with an increased expression of genes inducing steatosis (CD36, ADFP, PPARγ, CYP4A10, CYP4A14, UCP2) and also with a reduction in the expression of PPARα, a major activator of fatty acid oxidation, and that these changes are prevented by NAM administration. Moreover, these findings indicate that the hepatic reduction in total transmethylation flux caused by deletion of GNMT and the concomitant accumulation of SAMe can be compensated by NNMT if exogenous NAM is provided. Additionally, our results indicate that NAM administration to GNMT-KO mice prevents global DNA hypermethylation as well as the abnormal expression of numerous genes involved in fatty acid metabolism, oxidative stress, fibrosis, apoptosis and proliferation observed in untreated animals. More significant, NAM treatment not only normalized the expression of all these genes and proteins in GNMT-KO mice, but also prevented the development of fatty liver and fibrosis. The mechanism by which GNMT deletion leads to fibrosis is not known. Possibly, increased lipid accumulation and apoptosis in GNMT-KO hepatocytes may activate hepatic stellate cells (37,38), the central mediators of liver fibrogenesis. Accordingly, NAM may attenuate fibrogenesis by preventing hepatic fat accumulation and apoptosis via lowering SAMe content. At present, however, other alternatives as a direct effect of NAM on stellate cell activation cannot be excluded."
     
  2. Makrosky

    Makrosky Member

    Joined:
    Oct 5, 2014
    Messages:
    2,385
    Gender:
    Male
    What ? Niacinamide bad for the liver ? That catched my eye and I quickly checked the Wikipedia. It cites this article : https://www.ncbi.nlm.nih.gov/pubmed/11126400 to support that claim. I was also surprised by the claim of another user in the forum that says niacinamide can create insulin resistance.

    The article discusses briefly some therapeutic benefits and it doesn't neglect niacinamide possitive effects. However, the real scope of the article is just an evaluation of safety use, so here are the conclusions :

    Regarding insulin :
    Anyone versed on insulin/diabetic issues dare to comment that ?

    Regarding overall safety :
    So you can draw your own conclusions from that. Looking at the data, the conclusion should be obvious : Ray Peat's recommended dose of 100mg niacinamide daily is extremely unlikely to cause any of the problems commented on the article. Even 1g/day doses should be quite safe, although I would not stay at that dose for a long time just in case.

    3mg/kg doses as the article posted by haidut suggests should be very safe as well.

    I've uploaded the full article here (http://we.tl/u8Eeg5epn0) if it's deleted after a while, just pm me.
     
  3. raypeatclips

    raypeatclips Member

    Joined:
    Jul 8, 2016
    Messages:
    2,556
    @haidut In your long famous rant on the "RP says glucose helps T4 to T3, then why fructose?" thread you mention a couple of times that aspirin and nicinamide fatten the liver. Do you no longer think this is true, or only in high doses?
     
  4. BrianF

    BrianF Member

    Joined:
    Mar 25, 2016
    Messages:
    219
    Gender:
    Male
    Might niacinimide be able to treat NAFLD in a medium to high dose?
     
  5. TubZy

    TubZy Member

    Joined:
    Sep 30, 2016
    Messages:
    1,649
    Gender:
    Male
    Location:
    USA
    Is there enough niacinimide in energin to produce these positive effects?
     
  6. raypeatclips

    raypeatclips Member

    Joined:
    Jul 8, 2016
    Messages:
    2,556
    "The human equivalent dose of niacinamide was only 3mg/kg." There is 100mg niacinamide per serving of energin.
     
  7. TubZy

    TubZy Member

    Joined:
    Sep 30, 2016
    Messages:
    1,649
    Gender:
    Male
    Location:
    USA
    So if I was 200 ibs which translates to about 90kg, 3*90= 270, it would translate to 270mg of niacinimide daily? Did I do that right lol?
     
  8. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    I think it can treat it in any dose. It leans out the liver by blocking/reducing lipolysis.
     
  9. raypeatclips

    raypeatclips Member

    Joined:
    Jul 8, 2016
    Messages:
    2,556
    Do you still think aspirin fattens the liver and was the problem with the aspirin niacinamide combo regarding the liver?
     
  10. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    It will lower systemic lipolysis, so it will slow down weight loss if that is your goal. Usually, peripheral adiposity and liver fat are inversely correlated. Inhibiting excessive lipolysis leans out the liver but keeps the fat pads on your belly for longer.
     
  11. raypeatclips

    raypeatclips Member

    Joined:
    Jul 8, 2016
    Messages:
    2,556
    Interesting, thank you for the reply. It is amazing how much niacinamide is able to do. Weight loss is one of my goals but getting my liver healthy will probably solve many of my issues, so is a priority.
     
  12. Orion

    Orion Member

    Joined:
    Oct 23, 2015
    Messages:
    784
    Any thoughts on why small amounts of B3 (50mg), would cause me insomnia, more frequent low blood sugar night wakings?
     
Loading...