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nafld

  1. haidut

    Low testosterone (T) may drive kidney and liver disease (NAFLD) in men

    As many of my readers know, the "normal" range for T has been changed multiple times over the last several decades and each new iteration shifts both the lower and upper limit of the "normal" range downwards. In other words, a male with serum T in the 300 range would be considered "healthy" by...
  2. Ismail

    DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet

    https://pubmed.ncbi.nlm.nih.gov/33977946/ https://pubs.rsc.org/en/content/articlelanding/2021/FO/D0FO03471A
  3. Mauritio

    Activating FXR decreases PUFA in the liver

    Very interesting study showing that activating the Farnesoid X Receptor results in lower levels of MUFA and PUFA in the liver. (Farnesoid X receptor - Wikipedia) Lowers levels of MUFA are brought on by downregulating genes like SCD1. "Elevated expression levels of SCD1 is found to be...
  4. haidut

    Endotoxin (LPS) drives obesity, diabetes and CVD in young people

    It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal...
  5. Sefton10

    Citrus peel powder has a preventive effect on NAFLD, which can be related to the regulation of intestinal flora

    The Regulatory Effects of Citrus Peel Powder on Liver Metabolites and Gut Flora in Mice with Non-Alcoholic Fatty Liver Disease (NAFLD) https://www.mdpi.com/2304-8158/10/12/3022/htm
  6. haidut

    Cortisol causes fatty liver (as well as obesity, diabetes, etc)

    Not really a surprise for most of my readers, but it is always nice to see more evidence establishing various disorders attributed to "gluttony", "weak will", "addiction", etc as actual endocrine disturbances. And since the current study implicates cortisol, we can point the finger once again at...
  7. Mauritio

    Bromantane reduces liver fibrosis by 60%, kidney fibrosis by 50%

    This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis. I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not...
  8. haidut

    Oral testosterone + vitamin E may treat NAFLD, NASH, cirrhosis in humans

    Several years ago, I posted a few studies from the 1970s demonstrating very high cure rates of advanced cirrhosis in humans with a combination treatment of testosterone (T) and vitamin B1 (thiamine). Not bad for a condition modern medicine tells us is incurable and the only option the patient...
  9. haidut

    Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

    A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also...
  10. Lokzo

    Glycine Reduces NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome - 2020

    Amino acids alleviate liver disease Glycine is known to be reduced in patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), diseases with no approved treatments. Rom et al. found that glycine biosynthetic genes showed reduced expression in humans and...
  11. Ras

    Glycine Ameliorates NAFLD By Modulating FAO, Glutathione Synthesis, And The Gut Microbiome

    Altered the title to make it fit. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome Full text ABSTRACT Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic...
  12. koreus

    Just Got My Liver Enzymes Checked And They Are Elevated

    My Alanine transferase is way out of range which is worrying: Alanine transferase 220 IU/L (range 50 - 150) Gamma-GT 45 IU/L (range 34-335) Albumin 44 g/L (range 34 - 52) Alkaline phosphatase 81 IU/L (range 0 - 130) Globulin 30 g/L (range 19 - 35) Bilirubin 9 umol/L (range 0 - 40) Total...
  13. haidut

    Blocking Serotonin Treats Fatty Liver Disease (NAFLD / NASH)

    The bad news for serotonin just keeps on coming. Just minutes ago I posted about serotonin turning people into violent criminals, and being the actual cause of depression instead of its cure (as FDA and Big Pharma would have you believe). Now, the study below adds another pathology that is...
  14. haidut

    Vitamin E Can Treat/cure Severe Fatty Liver Disease (NASH) In Humans

    As many of my readers know, currently there is an epidemic of the condition known as non-alcoholic fatty liver disease (NAFLD). By some estimates, more than 30% (100mil) of people living in the US have NAFLD and in about 25% of those the condition will progress to the more severe form known as...
  15. haidut

    America’s Favorite Oil Causes Diabetes, Obesity, Autism, And Liver / Brain Disease

    A series of shockingly direct studies that do not shy away from pointing the finger at the real villain in modern public health history - PUFA, and more specifically the "essential" linoleic acid (LA). As the studies demonstrate, soy oil has strikingly detrimental effects on metabolic health and...
  16. haidut

    Daily Aspirin Reduces By 37% Risk Of Fatty Liver Progressing Into Cirrhosis

    Another great study about aspirin. What I particularly like about this study is that one of the authors is calling aspirin "a promising anti-fibrotic strategy for NAFLD". This is the first time I have heard a doctor refer to aspirin as anti-fibrotic chemical. Peat mentioned aspirin as one of the...
  17. haidut

    Epidemic Of NAFLD And NASH In Young People

    Yet another sad reminder of just how much the health of the average person has declined over the last 20 years. They truly are becoming the "new old". The "Young" Have Now Become The Old If these trends are not reversed or at least slowed down, we may start seeing people in their 20s filing for...
  18. haidut

    Liver Disease Is Caused By Low ATP Driven By Fat (PUFA) Oxidation

    I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...
  19. haidut

    Inosine Increases ATP And Reverses NAFLD (and Likely Other Liver Disease)

    As I mentioned in another recent thread on inosine and serotonin/cortisol, many pathologies are simply signs/symptoms of inefficient ATP synthesis and restoring proper synthesis or replenishing ATP levels through precursors often reverses the pathology. These two studies below show that fatty...
  20. haidut

    Androgen Deficiency As The Main Cause Of Chronic Disease In Males

    This is one of the most comprehensive reviews that I have ever come across on the topic of androgens and their role in male health. It is authored by one of the most renowned experts in urology - the former director of the Department of Urology at Boston University (BU) School of Medicine. Given...
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