nafld

Not really a surprise for most of my readers, but it is always nice to see more evidence establishing various disorders attributed to "gluttony", "weak will", "addiction", etc as actual endocrine disturbances. And since the current study implicates cortisol, we can point the finger once again at...

This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis. I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not...

Several years ago, I posted a few studies from the 1970s demonstrating very high cure rates of advanced cirrhosis in humans with a combination treatment of testosterone (T) and vitamin B1 (thiamine). Not bad for a condition modern medicine tells us is incurable and the only option the patient...

A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also...

Amino acids alleviate liver disease Glycine is known to be reduced in patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), diseases with no approved treatments. Rom et al. found that glycine biosynthetic genes showed reduced expression in humans and...

Altered the title to make it fit. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome Full text ABSTRACT Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic...

My Alanine transferase is way out of range which is worrying: Alanine transferase 220 IU/L (range 50 - 150) Gamma-GT 45 IU/L (range 34-335) Albumin 44 g/L (range 34 - 52) Alkaline phosphatase 81 IU/L (range 0 - 130) Globulin 30 g/L (range 19 - 35) Bilirubin 9 umol/L (range 0 - 40) Total...

The bad news for serotonin just keeps on coming. Just minutes ago I posted about serotonin turning people into violent criminals, and being the actual cause of depression instead of its cure (as FDA and Big Pharma would have you believe). Now, the study below adds another pathology that is...

As many of my readers know, currently there is an epidemic of the condition known as non-alcoholic fatty liver disease (NAFLD). By some estimates, more than 30% (100mil) of people living in the US have NAFLD and in about 25% of those the condition will progress to the more severe form known as...

A series of shockingly direct studies that do not shy away from pointing the finger at the real villain in modern public health history - PUFA, and more specifically the "essential" linoleic acid (LA). As the studies demonstrate, soy oil has strikingly detrimental effects on metabolic health and...

Another great study about aspirin. What I particularly like about this study is that one of the authors is calling aspirin "a promising anti-fibrotic strategy for NAFLD". This is the first time I have heard a doctor refer to aspirin as anti-fibrotic chemical. Peat mentioned aspirin as one of the...

Yet another sad reminder of just how much the health of the average person has declined over the last 20 years. They truly are becoming the "new old". The "Young" Have Now Become The Old If these trends are not reversed or at least slowed down, we may start seeing people in their 20s filing for...

I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...

As I mentioned in another recent thread on inosine and serotonin/cortisol, many pathologies are simply signs/symptoms of inefficient ATP synthesis and restoring proper synthesis or replenishing ATP levels through precursors often reverses the pathology. These two studies below show that fatty...

This is one of the most comprehensive reviews that I have ever come across on the topic of androgens and their role in male health. It is authored by one of the most renowned experts in urology - the former director of the Department of Urology at Boston University (BU) School of Medicine. Given...

Peat wrote in one of his articles that alcohol is getting a bad reputation for causing all sorts of liver disease and even liver cancer, but alcohol by itself is fairly neutral for the liver and that the role of PUFA, iron and endotoxin is being neglected by mainstream medicine. The study below...

I think most people on this forum know about the link between estrogen and liver disease. Peat has written at length about it and there is officially published data spanning more than century showing that (just like "autoimmune" conditions) liver disease has much higher incidence in women, thus...

At 2 minutes and 3 seconds

I originally got interested in vitamin E due to Ray Peat’ s writings on its anti-estrogenic effects. One of the things that jumped out while researching this vitamin, was the slew of studies and evidence about its liver protective effects. I suggest anyone with liver problems (elevated enzymes...

Adipocyte iron regulates adiponectin and insulin sensitivity. - PubMed - NCBI Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In humans, normal-range...