Estrogen's Anti-Fibrotic, Antioxidant Effects (?)

LCohen

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Chronic hepatitis C and fibrosis: evidences for possible estrogen benefits. - PubMed - NCBI

"A number of studies suggest that the estrogen, at physiological levels, presents an antifibrogenic action probably through an antioxidant effect, decreasing the levels of lipid peroxidation products in the liver and blood, thus inhibiting the myofibroblastic transformation of stellate cells and contributing for gender-associated differences in relation to the fibrosis development."

Estrogen Receptor Alpha Expression and Liver Fibrosis in Chronic Hepatitis C Virus Genotype 1b: A Clinicopathological Study
"Estradiol acts as a powerful antioxidant which blocks lipid oxidation reactions in liver (14) and inhibits the production of active oxygen radicals and lipid peroxidation in oxidatively-influenced rat hepatocytes; on account of this, it blocks depletion of antioxidant enzymes (15). In a rat model of liver fibrogenesis, estrogens had protective effects on liver fibrosis with an evidence of a direct beneficial effect on fibrogenesis (11). Our results support the experimental data published previously which showed the antifibrotic effects of estrogen on liver as well as on other different tissues"

Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats. - PubMed - NCBI
"These findings suggest that estradiol suppressed the induction of hepatic fibrosis, and may in part underlie the more rapid progression in males of hepatic fibrosis and its complications."

Estrogen receptor-beta prevents cardiac fibrosis. - PubMed - NCBI

Estrogen reduces CCL4- induced liver fibrosis in rats
 

Peatress

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Since estrogen is often a promoter of fibrosis, acting in a variety of ways, it should be kept under control by eating enough protein, keeping thyroid function relatively high, and if necessary by using progesterone and other antiestrogenic hormones. A protein deficiency is thrombogenic (clot forming), and probably excitotoxic.
Magnesium, taurine, and niacinamide have many protective functions, and can help to reduce or reverse inflammatory and fibrogenic processes. Ray Peat
 

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