It's Official - Caffeine Prevents And Slows Liver Fibrosis / Cirrhosis, Cancers

haidut

Member
Joined
Mar 18, 2013
Messages
17,533
Location
USA / Europe
I have posted quite a few studies on the effects of caffeine in preventing and even reversing liver disease, even as serious as late stage cirrhosis / fibrosis. However, all of these studies were done on animals and the official medical position was that there was no evidence caffeine would do the same in humans. Well, that position has changed. The official report from WHO now says that caffeine can prevent a wide range of liver diseases including NAFLD, alcoholic hepatitis, hepatitis C & B, fibrosis / cirrhosis, and liver cancer. It also says that caffeine can reverse many of the these conditions and for people with very advanced fibrosis / cirrhosis caffeine can probably slow down the progression to the point where it would not have in impact on their expected lifespan.

Now drinking coffee can protect against most liver diseases

"...Last week the World Health Organisation withdrew its previous warnings on the link between coffee and bladder cancer, and instead said the drink could, in fact, help protect against certain cancers that affect the womb and liver. The British Liver Trust today adds to the growing weight of evidence around the health benefits of drinking coffee, publishing an 83-page report summarising all existing research on the subject. It concludes that coffee protects against fatty liver disease, liver fibrosis and liver cirrhosis – all severe conditions which can be fatal. And for those who already have liver disease, drinking coffee can slow its progression."

"...Non-alcoholic fatty liver disease – which is usually associated with being overweight – was until recently considered rare. But modern sedentary lifestyles and poor diets means an estimated one in five people in the UK are now in the early stages of the disease, which can eventually lead to life-threatening cirrhosis, a condition more commonly associated with alcoholism. Recent research, however, has suggested that drinking around six espressos, or three large cappuccinos, each day could ward off non-alcoholic fatty liver disease, even among the obese. Other major causes of liver problems include blood-borne viruses – such as hepatitis A, B and C – which can cause permanent liver damage and increase the risk of liver cancer. The World Health Organisation, which published its report in the Lancet Oncology medical journal last week, found that the risk of liver cancer decreases 15 per cent for each cup of coffee per day."

"...Experts are not certain why coffee seems to have such a protective impact on the liver, but there is growing evidence that when caffeine enters the body, one of the molecules it is broken down into – paraxanthine – may slow the growth of tissues that damage the liver."

And while the article says that "experts" are not sure why caffeine has such a strong protective effect, I'd venture a guess that it may have something to do with caffeine being an antagonist on the serotonin 5-HT2 "receptor". Antagonism on 5-HT2 has been shown to be behind the anti-fibrotic effects of drugs like terguride, lisuride and cyproheptadine.
Caffeine Is A Serotonin Receptor Antagonist
 
Last edited:

Mufasa

Member
Joined
Jun 10, 2016
Messages
538
Wow, awesome :)

Is caffeine the likely mechanism that coffee is helpful, or could other molecules in coffee play a role?

I wonder if caffeine topical could also be helpful in reversing fibrosis in the scalp, seen in balding. I hope so, because I apply Solban everyday on my hairline :)
 

Tarmander

Member
Joined
Apr 30, 2015
Messages
3,508
Coffee really is so much more then caffeine. I have had 6 espressos in one day and felt relaxed, calm, and in the moment. I have taken caffeine pills and felt strung out, cracked out, and on my way out.

Edit: although I will say that caffeine pills helped me build tolerance for coffee much quicker. So they aren't totally useless.
 

Mufasa

Member
Joined
Jun 10, 2016
Messages
538
Coffee really is so much more then caffeine. I have had 6 espressos in one day and felt relaxed, calm, and in the moment. I have taken caffeine pills and felt strung out, cracked out, and on my way out.

Yeah, haidut posted a mechanism for that recently.

As I have mentioned on the Danny Roddy shows and on many threads in this forum, cortisol synthesis depends on the enzyme 11β-HSD1 and it converts the inactive cortisone into the active cortisol. Big Pharma is in hot pursuit of an effective and selective 11β-HSD1 inhibitor as a treatment of obesity, diabetes, Cushing syndrome, depression, mania, and a few other serious conditions. The study below investigated the 11β-HSD1 inhibiting effects of compounds in espresso coffee. It found caffeine to be neutral in regards to 11β-HSD1 and an unknown compound in coffee to be a strong inhibitor. The unknown inhibitor of 11β-HSD1 in coffee seems to be very water soluble but given that there are several thousand such compounds present in coffee it would take some time and effort before it is isolated. For the record, cocoa powder was not an effective 11β-HSD1 inhibitor.

That said, many people like myself don't experience any sides on high caffeine dosages from supps. I prefer caffeine supps because I already drink 5L of liquid, and adding 10 cups of coffee to that seems like an overkill of liquid to me.
 

lindsay

Member
Joined
Jul 1, 2013
Messages
973
Location
United States
Coffee FTW :): I was going to ask if coffee is superior to just caffeine, but then I read through the thread notes. What about black tea? I know it's no coffee, and I rarely drink tea, but I'm curious if it contains some of the beneficial compounds for the liver? Although, I am sure the beans are where it's at. Now I have a good excuse to keep making that cold brew and espresso :):
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,533
Location
USA / Europe
Just wanted to point out that the study on coffee and cortisol found that even caffeine-free coffee extract inhibited cortisol, so you don't have to load up on regular expresso if you cannot tolerate caffeine. Btw, since coffee is rich in vitamin B3, the study found the cortisol-inhibiting compound to be water soluble (like B3 is), and the studies I posted on B3 lowering cortisol it could very well be vitamin B3 behind these beneficial effects of coffee. But until we know more, I would focus on the coffee extract. Instant coffee would be great way to get this compound in high doses.
 

milk_lover

Member
Joined
Aug 15, 2015
Messages
1,769
Instant coffee would be great way to get this compound in high doses.
I found this website (Coffee (instant coffee) | Whole Food Catalog) that claims 1 tablespoon of instant coffee (the amount I usually drink per cup) has around a whooping 700mg B3 and 1300 mcg biotin. Are those values real? :woot:
So coffee on hair does provide more than the caffeine for hair health. Caffeine, magnesium, B3, and biotin are all arguably good for hair.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,533
Location
USA / Europe
I found this website (Coffee (instant coffee) | Whole Food Catalog) that claims 1 tablespoon of instant coffee (the amount I usually drink per cup) has around a whooping 700mg B3 and 1300 mcg biotin. Are those values real? :woot:
So coffee on hair does provide more than the caffeine for hair health. Caffeine, magnesium, B3, and biotin are all arguably good for hair.

That is a little suspect. I am getting a quote for about 28mg vitamin B3 in 100g of instant coffee. Can't open your link so don't know if we are talking about the same type of coffee.
 

GAF

Member
Joined
Dec 28, 2014
Messages
750
Age
64
Location
Dallas Texas
Here is the report referred to above.
 

Attachments

  • The-health-benefits-of-coffee-BLT-report-June-2016.pdf
    660.9 KB · Views: 95

Peater Piper

Member
Joined
Mar 18, 2016
Messages
684
At this point, I'm doubtful that caffeine has much to do with the majority of coffee's benefits. There's a few conflicting reports, but generally, people that drink decaf have the same reduced risk for liver issues. Coffee seems to reduce the risk of intestinal permeability by raising levels of ZO-1. Coconut oil also protects the liver by reducing intestinal permeability caused by ethanol exposure. Since alcohol primarily damages the liver through endotoxemia, coffee, like coconut oil, may protect the liver by reducing the bacterial load through gut barrier modulation.

Increase in coffee consumption could provide protective effect in non-alcoholic fatty liver disease

The production of H2O2 from coffee consumption may have an antiseptic role as well.

Coffee drinking increases levels of urinary hydrogen peroxide detected in healthy human volunteers. - PubMed - NCBI

Then finally, of course, you have the various micronutrients and polyphenols that could be beneficial. Something I rarely see mentioned is that coffee contains a-amylase and a-glucosidase inhibitors (namely the polyphenols and tannic acid). If it's being consumed with meals then there's a likelihood it's causing carbohydrate malabsorption, or at least a delayed absorption, which would lower the glycemic index and total calories of the foods consumed. From Peat's perspective, this is probably not a good thing since he prefers highly digestible carbohydrates and eschews resistant starch and fiber, but it's interesting that the majority of cultures have taken to food products that also inhibit the carbohydrate digestive enzymes, from coffee, to tea (all kinds, but especially green tea), to herbal teas, many spices, vinegar, etc.
 

Birdie

Member
Joined
Aug 10, 2012
Messages
1,971
Location
USA
I always remember Ray's saying that decaf is okay when somebody asked him.
 

Ideonaut

Member
Joined
Sep 20, 2015
Messages
447
Location
Seattle
Coffee really is so much more then caffeine. I have had 6 espressos in one day and felt relaxed, calm, and in the moment. I have taken caffeine pills and felt strung out, cracked out, and on my way out.

Edit: although I will say that caffeine pills helped me build tolerance for coffee much quicker. So they aren't totally useless.
I always amazed when I see people don't know the difference between "then" and "than."
 

jyb

Member
Joined
Nov 9, 2012
Messages
2,771
Location
UK
Coconut oil also protects the liver by reducing intestinal permeability caused by ethanol exposure. Since alcohol primarily damages the liver through endotoxemia, coffee, like coconut oil, may protect the liver by reducing the bacterial load through gut barrier modulation.

That's not coconut oil specifically but saturated fatty acids generally, longer chains found in dairy fats for example can have other protective effects against endotoxin caused by ethanol.

Dietary fat sources differentially modulate intestinal barrier and hepatic inflammation in alcohol-induced liver injury in rats. - PubMed - NCBI

There is a long list of studies like this, usually using a mix of beef tallow & MCT as saturated fat and comparing against other diets including PUFA, and other non-fat variables in the diet (type of bacteria and blood glucose condition).
 
Last edited:

Peater Piper

Member
Joined
Mar 18, 2016
Messages
684
That's not coconut oil specifically but saturated fatty acids generally, longer chains found in dairy fats for example can have other protective effects against endotoxin caused by ethanol.

Dietary fat sources differentially modulate intestinal barrier and hepatic inflammation in alcohol-induced liver injury in rats. - PubMed - NCBI

There is a long list of studies like this, usually using a mix of beef tallow & MCT as saturated fat and comparing against other diets including PUFA, and other non-fat variables in the diet (type of bacteria and blood glucose condition).
My main point regarding the coconut oil is that it stops the endotoxin migration through maintaining tight gut junctions, and coffee may offer a similar benefit, which could be why it's so good for the liver (easing endotoxin burden). Long chain SFAs still allow the endotoxin into the blood stream, though they can offer protection through various mechanisms at that point, but it's more ideal to prevent the endotoxin migration in the first place. Also, from the study you posted, "ethanol-induced downregulations of intestinal occludin and zonula occludens-1 were normalized by MCT but not CB." That's ZO-1, which coffee was shown to upregulate in the study I posted above, so very similar action to coconut oil. Thus, a diet of coffee plus some MCTs should be an effective treatment for leaky gut, plus their antimicrobial actions to reduce endotoxin in the intestines, and if coconut oil is being consumed for the MCTs, the long chain SFAs should provide some protection for any endotoxin that does enter the bloodstream.
 

jyb

Member
Joined
Nov 9, 2012
Messages
2,771
Location
UK
Thus, a diet of coffee plus some MCTs should be an effective treatment for leaky gut, plus their antimicrobial actions to reduce endotoxin in the intestines, and if coconut oil is being consumed for the MCTs, the long chain SFAs should provide some protection for any endotoxin that does enter the bloodstream.

It's complementary, the studies usually use a varied saturated fatty acids profile to show the benefits.
 

lindsay

Member
Joined
Jul 1, 2013
Messages
973
Location
United States
My main point regarding the coconut oil is that it stops the endotoxin migration through maintaining tight gut junctions, and coffee may offer a similar benefit, which could be why it's so good for the liver (easing endotoxin burden). Long chain SFAs still allow the endotoxin into the blood stream, though they can offer protection through various mechanisms at that point, but it's more ideal to prevent the endotoxin migration in the first place. Also, from the study you posted, "ethanol-induced downregulations of intestinal occludin and zonula occludens-1 were normalized by MCT but not CB." That's ZO-1, which coffee was shown to upregulate in the study I posted above, so very similar action to coconut oil. Thus, a diet of coffee plus some MCTs should be an effective treatment for leaky gut, plus their antimicrobial actions to reduce endotoxin in the intestines, and if coconut oil is being consumed for the MCTs, the long chain SFAs should provide some protection for any endotoxin that does enter the bloodstream.

So what you are saying is, Coffee "bulletproofed" with CO or MCT's instead of cream would be super fantastic! I might try this sometimes. While I adore my cream in my coffee, I bet it would be delicious with virgin coconut oil. Maybe I will give it a try when I can be close to a toilet ;)
 
Similar threads
Thread starter Title Forum Replies Date
E Corona / COVID-19 : Prevention And Treatment - The Official Chinese Handbook (eBook) Health 2
D The California Official "Seal Of Approval" For Olive Oil Fats 2
Lewis Acid CIA Official ‘Behind Soleimani’s Assassination’ Killed In Downed Plane In Afghanistan? Political Talk, Alternative World Theories 1
haidut It's Official - Cancer Surgery Drives Metastasis, Aspirin Can Prevent Them Scientific Studies 5
DaveFoster Foster Your Health Podcast - Official Thread Miscellaneous Health Discussions 73
TheHound Official Hairloss Thread Hair & Nails 131
Amazoniac It's Not Official - Eggshell Pigment Might Also Be Influenced By Solar Radiation Articles & Scientific Studies 2
Hugh Johnson The Term “Conspiracy Theory” Was Invented By The CIA In Order To Prevent Disbelief Of Official Gover Society 0
haidut It's Official - Aspirin Stops Breast Cancer In 80% Of Patients, Even Terminal Ones Scientific Studies 56
Y It's Official - Low Testosterone Suppresses T4 To T3 Conversion / Lowers Metabolism Articles & Scientific Studies 3
haidut It's Official - Estrogen Suppresses / Lowers Metabolism Thyroid and Hormones 8
charlie The Official Unsubscribe Issue Testing Topic. Please Help Test! Yes, This Means YOU! Suggestions, Complaints, Board Glitches 20
haidut Optimal Levels Of TSH Are Much Lower Than Official Guidelines Scientific Studies 10
haidut Official dietary fat guidelines were NOT based on evidence Scientific Studies 0
LucyL Press Conferences, Official Releases, CDC, WHO, etc.... Ebola 9
haidut From BMI to diet - most official health guidelines are wrong Discussing Dietary Models 1
haidut Who controls official nutrition policy in the US? Society 7
C Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging Coffee 16
Lokzo Teacrine Benefits: An Alternative To Caffeine/Coffee Supplements 0
C How to deal with the negative side effects of caffeine ? Ask For Help or Advice 0
B Confused about Caffeine Ask For Help or Advice 9
ddjd insomnia from caffeine disappears on fruitarian diet Ask For Help or Advice 79
Mauritio Cistanche more effective at decreasing lipid peroxidation and free radicals than Vitamin E and Caffeine Science 46
TopGun1911 How do you deal with caffeine withdrawals? Ask For Help or Advice 3
B Caffeine irratible? Ask For Help or Advice 7
B Caffeine irratible, trouble sleeping? Caffeine 14
IROM Alpecin shampoo: Caffeine, Taurine and Niacinamide (are corporations on to Peating?) Hair & Nails 9
G Starting Caffeine - Lots of Health Problems - Asthma, Erectile Dysfunction, Hypertonic Pelvic Floor, Hair Loss, Anxiety/Depression Caffeine 54
N Can I Dissolve Caffeine Powder In Boiled Water And Then Apply On My Scalp? Hair & Nails 22
M Post Caffeine Symptoms Symptoms, Causes 13
U Anyone Had Health Improvements From Reducing Caffeine Intake? Coffee 42
M How To Treat Leaky Blood-brain-barrier If One Is Sensitive To Caffeine Pill? Ask For Help or Advice 3
H Caffeine Giving Me Anxiety Ask For Help or Advice 1
ScurveDream DHEA Or Pregnenolone To Combat Possible Caffeine-induced Stress? Ask For Help or Advice 9
S Other Things Like Caffeine To Try? Caffeine 3
J Mixing Caffeine, Aspirin, & Antihistamine Experiments 6
ecstatichamster Caffeine Lowers Cerebral Blood Flow Scientific Studies 7
E New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson's Disease Scientific Studies 2
Mito New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson’s Articles & Scientific Studies 0
Tristan Loscha Caffeine Decreases Vitamin D Receptor Protein Expression In Vitro D 0
Kingpinguin How Do People Handle Caffeine? Coffee 32
Hgreen56 Caffeine Cause Joint Pain/inflammation Supplements, Pharmaceutical Drugs 1
Hgreen56 Has Someone Positive Experience Lowering Cortisol With Caffeine? Supplements, Pharmaceutical Drugs 4
fitnessgirl Caffeine 3x300mg/day Safe? Supplements, Pharmaceutical Drugs 1
S.Seneff The Effects Of Caffeine On Lipid And Mineral Content In The Serum Of Rats Caffeine 6
maillol Caffeine Reduces Fatty Liver But Increases FFA Metabolism 32
J Caffeine Ask For Help or Advice 7
H How Does Caffeine Stop My Hairloss? Hair & Nails 2
S How To Take Caffeine Without Raising Blood Pressure Caffeine 22
E Is Caffeine Tolerance A Big Deal? Coffee 0

Similar threads

Top