It seems the individual differences in how well we tolerate caffeine has a lot to do with how quickly we can metabolise it. The literature suggests that people who are fast metabolisers of caffeine experience positive health effects of increasing coffee consumption, presumably due to being able to rapidly neutralise the caffeine while enjoying more of the other nutrients found in coffee. On the other hand slow caffeine metabolisers show increased risk of disease with increasing coffee consumption. This would suggest that caffeine itself has little beneficial effect on the body beyond perhaps as a hormetic stimulus, and the apparent benefit of increasing caffeine consumption just acts as a proxy for your overall liver health and ability to metabolise poisons.
In this regard its been found that cruciferous vegetable consumption substantially increases the activity of the enzyme that metabolises caffeine, CYP1A2. In one study, eating 500g of broccoli per day more than doubled the activity of this enzyme in men.
https://www.ncbi.nlm.nih.gov/pubmed/17266520
Has anyone tried this, to consume a lot of cruciferous vegetables and see if it has improved the way that coffee affects you?
In this regard its been found that cruciferous vegetable consumption substantially increases the activity of the enzyme that metabolises caffeine, CYP1A2. In one study, eating 500g of broccoli per day more than doubled the activity of this enzyme in men.
https://www.ncbi.nlm.nih.gov/pubmed/17266520
Has anyone tried this, to consume a lot of cruciferous vegetables and see if it has improved the way that coffee affects you?