Caffeine restores cytochrome C damaged by sepsis

haidut

Member
Forum Supporter
Joined
Mar 18, 2013
Messages
19,798
Location
USA / Europe
Animal study and it only looked at effects of sepsis on the heart, however I do not see why the results would not apply to other organs damaged by similar methods like endotoxin (which can be considered a milder version of sepsis). Human dose would be equal to one cup of coffee or about 80mg-100mg of caffeine for most people.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970220/

"...Mitochondrial dysfunction and impaired oxidative phosphorylation may underlie sepsis-induced organ dysfunction (1, 3-6). It has been suggested that CcOX, the terminal oxidase of the electron transport chain, regulates aerobic ATP production (19). Defects in CcOX activity during sepsis could incapacitate bioenergy production and manifest as organ failure. cAMP-dependent phosphorylation of CcOX is known to stimulate and optimize the efficiency of oxidative phosphorylation (11). Therefore, we hypothesized that caffeine, a well-known inhibitor of cAMP-phosphodiesterase, could increase myocardial CcOX function during sepsis and potentially improve cardiac performance and enhance survival. Consistent with previous work, CLP induced a significant impairment in myocardial CcOX activity (9). A daily injection of caffeine beginning 24 hours post-CLP (roughly equivalent to the human consumption of a single cup of coffee) restored CcOX function to sham values at 48 hours. Increased oxygen extraction and myocardial oxygen consumption in the isolated rat heart preparation corroborated this finding in situ. These data strongly suggest that caffeine stimulated oxidative phosphorylation during sepsis and were associated with significant improvements in cardiac function and survival.
 

Similar threads

Back
Top Bottom