Dr David Sinclair's Anti-Aging Supplement List

[Sicknature]

David Sinclair’s Anti-Aging Supplement List 2022 – Food Security

Would like everyone's thoughts on this? Did Raypeat have many views on supplements and did he take any?

 

[Candeias]

Many Longecity forum users use resveratrol, fish oil, metformin, cialis, etc. To my astonishment, for those who seem to study substances in such detail, I have yet to investigate this further..

 

[youngsinatra]

NAD precursors (NMN in this case) vitamin D and K2, CoQ10 are pro-metabolic from the bioenergetic perspective and probably have some good effects.

Sinclair thinks that hormetic stress is beneficial for longevity (ie. fasting / plant compounds like resveratrol / carbohydrate/protein restriction) but this is completely contrary to Ray Peat‘s idea of lowering the stress burden of an organism for optimal health and longevity.

Metformin can cause the Warburg Effect in some cases. It also causes B1 and potentially B12 deficiency.
Cholesterol is needed for stress protection and steroidogenesis, lowering it can be damaging.

 

[Limon9]

Diabetes drug linked to genital birth defects in baby boys​

Metformin's canonical method of action is the phosphorylation of AMPK, stimulating glucose uptake, but aspirin does this in similar doses, apparently without the whole lactic-acidosis-birth-defects... thing. The vitamin K might be useful as an adjuvant therapy for the statins, in an attempt to prevent the well-documented arterial calcification associated with those drugs.

"In the last 20 years, there have been many studies showing that lowering cholesterol increases mortality, especially from cancer and suicide, and that people with naturally low cholesterol are more likely to die from cancer, suicide, trauma, and infections than people with normal or higher than average cholesterol. The increased mortality from accidents and suicide when cholesterol is lowered is reminiscent of the problems seen in progesterone deficiency, and it's very likely that a deficiency of the neurosteroids accounts for it. A deficiency of progesterone and other neurosteroids (the steroids synthesized by the nerves themselves) causes depression of mood and impaired learning ability, among other neurological changes."

Cholesterol, longevity, intelligence, and health. Peat RF.

In a way, I feel like Dr. Peat achieved longevity by continuing his life "in fewer bodies", but I don't think anyone will care about David Sinclair when he dies at approximately average life expectancy.

 

[Fred]

Sinclair is a resveratrol guy. See Ray Peat's article "Don’t Be Conned By The Resveratrol Scam"

 

[Pablo Cruise]

I do not see any of the typical anti oxidants, ie, NAC, and no Vit E or fish oils unless he gets in his diet.

As a scientist I have never believed in statins unless used for post cardiac surgery or events. My entire family has high cholesterol 210 approx but live into their 90's which is why I will not take. As we know cholesterol is a precursor to hormones and prefer not to interrupt that cycle in any way. Everyone's choice.

I do take already everything he mentions except spermidine and statin.

 

[Sicknature]

I do not see any of the typical anti oxidants, ie, NAC, and no Vit E or fish oils unless he gets in his diet.

As a scientist I have never believed in statins unless used for post cardiac surgery or events. My entire family has high cholesterol 210 approx but live into their 90's which is why I will not take. As we know cholesterol is a precursor to hormones and prefer not to interrupt that cycle in any way. Everyone's choice.

I do take already everything he mentions except spermidine and statin.

Thank you very much for this. I researched and you were indeed correct. Statin is known to lower testosterone and disrupt the androgen receptors. A big no no, especially as a man.

Your thoughts on this articles (Websites) review on one particular supplement on this list; Coenzyme Q10 (coQ10) ?

I am very early 30s but I aim to make sure I have everything on-point from now.

This article is suggesting with reference to studies suggests that antioxidants can accelerate ageing and thus taking this would be silly, given it is a very strong antioxidant. Supposedly

Are you an 'actual' scientist?

Link to article: The Anti-Aging Supplements David Sinclair Takes | Skeptical Review

 

[Candeias]

I do not see any of the typical anti oxidants, ie, NAC, and no Vit E or fish oils unless he gets in his diet.

As a scientist I have never believed in statins unless used for post cardiac surgery or events. My entire family has high cholesterol 210 approx but live into their 90's which is why I will not take. As we know cholesterol is a precursor to hormones and prefer not to interrupt that cycle in any way. Everyone's choice.

I do take already everything he mentions except spermidine and statin.

Just out of curiosity, why do you take TMG?

 

[Sicknature]

NAD precursors (NMN in this case) vitamin D and K2, CoQ10 are pro-metabolic from the bioenergetic perspective and probably have some good effects.

Sinclair thinks that hormetic stress is beneficial for longevity (ie. fasting / plant compounds like resveratrol / carbohydrate/protein restriction) but this is completely contrary to Ray Peat‘s idea of lowering the stress burden of an organism for optimal health and longevity.

Metformin can cause the Warburg Effect in some cases. It also causes B1 and potentially B12 deficiency.
Cholesterol is needed for stress protection and steroidogenesis, lowering it can be damaging.

Insightful. Thank you. Any reason why he still advocates for it then?

He also advocates for plant based protein mediterranean diets. Doesn't have any animal protein in his diet at all whatsoever.

His biological age is 42 apparently and he is 53. He also looks early 40s while being 52 which is staggering.

 

[Sicknature]

Many Longecity forum users use resveratrol, fish oil, metformin, cialis, etc. To my astonishment, for those who seem to study substances in such detail, I have yet to investigate this further..

What was this stuff Mr Ray Peat was saying about Omega 3 fish oil increasing the probability of diabetes?

 

[Sicknature]

Diabetes drug linked to genital birth defects in baby boys​

Metformin's canonical method of action is the phosphorylation of AMPK, stimulating glucose uptake, but aspirin does this in similar doses, apparently without the whole lactic-acidosis-birth-defects... thing. The vitamin K might be useful as an adjuvant therapy for the statins, in an attempt to prevent the well-documented arterial calcification associated with those drugs.



In a way, I feel like Dr. Peat achieved longevity by continuing his life "in fewer bodies", but I don't think anyone will care about David Sinclair when he dies at approximately average life expectancy.

He claims his biological age is 42. He is very mainstream.

If you wanna see just how mainstream the guy is go and check out his linkedt.ree page where it's documenting all the YouTube, Spotify, Apple etc podcasts he's appeared on.

Even CNN:


View: https://edition.cnn.com/videos/health/2022/06/03/david-sinclair-life-itself-wellness.cnn?utm_medium=social&utm_source=linktress&utm_campaign=cnn+life+itself+talk+with+gov.+baker+


Here's the talk he gave.

Not comparing him with Ray Peat or anything dude, as you did that, but I am saying he does have credentials.

 

[Candeias]

What was this stuff Mr Ray Peat was saying about Omega 3 fish oil increasing the probability of diabetes?

J Nutr. 1991 Apr;121(4):484-91.

Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women.

Meydani M1, Natiello F, Goldin B, Free N, Woods M, Schaefer E, Blumberg JB, Gorbach SL.

Abstract

Fifteen young (22-35 y) and 10 older (51-71 y) women received six capsules of fish oil (Pro-Mega)/d, providing a total of 1,680 mg eicosapentaenoic (EPA), 720 mg docosahexaenoic (DHA), 600 mg other fatty acids, and 6 IU vitamin E. Blood was collected before and after 1, 2 and 3 mo of supplementation. Compliance was confirmed by the significant increase in plasma EPA and DHA in all women. Older women had a significantly higher increase in EPA and DHA than did young women (10-fold increases in EPA and 2.5-fold increases in DHA vs. 8-fold in EPA and 2-fold in DHA for older and young women, respectively). The decrease in the arachidonic acid:EPA ratio was more dramatic in the older women. Plasma total triglycerides (TG) decreased significantly, and the ratio of polyunsaturated fatty acids to saturated fatty acids was significantly (P less than 0.01) increased. Plasma vitamin E levels did not change significantly after supplementation; however, after 3 mo of supplementation by young women, plasma vitamin E was significantly lower than after 1 mo. The vitamin E: TG ratio was significantly increased and vitamin E: (EPA + DHA) significantly decreased. All women showed a significant increase in plasma lipid peroxide through mo 2 of supplementation. After 2 mo, older women had significantly higher lipid peroxide levels than young women. The lipid peroxide:TG ratio, which declined by mo 3, was still significantly higher than baseline. These data indicate that although long-term fish oil supplementation may be beneficial in reducing plasma total TG, susceptibility of plasma lipids to free radical attack is potentiated.(ABSTRACT TRUNCATED AT 250 WORDS)

 

[Sicknature]

Fanboys or objective discussion? Lol. Is Ray Peat's stuff backed by more crystal clear studies?

 

[Candeias]

Fanboys or objective discussion? Lol. Is Ray Peat's stuff backed by more crystal clear studies?

Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction​

Abstract​

Objective: To assess the oxidative burden of a highly concentrated compound of n-3 PUFAs as compared to corn oil by measuring thiobarbituric acid-malondialdehyde complex (TBA-MDA) by HPLC. We also studied the influence on TBA-MDA of statins combined with n-3 PUFAs or corn oil.
Design: A prospective, randomised, double-blind, controlled study.
Setting: One hospital centre in Stavanger, Norway.
Subjects: A total of 300 subjects with an acute myocardial infarction (MI).
Interventions: Gelatine capsules, containing 850-882 mg EPA and DHA as concentrated ethylesters, or 1 g of corn oil, were ingested in a dose of two capsules twice a day for at least 1 y. Alpha-tocopherol (4 mg) was added to all capsules to protect the PUFAs against oxidation.
Results: After 1 y TBA-MDA increased modestly in the n-3 PUFA group (n=125), as compared to the corn oil group (n=130), P=0.027. Multiple linear regression analyses of fatty acids in serum total phospholipids (n=56) on TBA-MDA measured after 12 months intervention, showed no dependency. Performing best subsets regression, serum phospholipid concentration of arachidonic acid (20:4 n-6 PUFA) was identified as a predictor of TBA-MDA at 12 months follow-up, P=0.004. We found no impact of statins on TBA-MDA.
Conclusion: TBA-MDA increased modestly after long-term intervention with n-3 PUFAs compared to corn oil post-MI, suggesting biological changes induced by n-3 PUFAs, rather than simply reflecting their concentration differences. The peroxidative potential of n-3 PUFAs was not modified by statin treatment.

I mean, you don't need help searching, do you?

 

[Ben.]

He claims his biological age is 42.

ive read his book and was excited at first about many things such as resveratol etc.

however i think to have found out somewhere at some point that he uses botox, dyes his hair and is involved in massive conflict of interests among other things.

the reality about longevity is that noone has figured it out yet and thoose who claim they have have to prove it in the next 50-100 years. the question is also at what cost does the longevity come. if it doesnt come with health and youthfull metabolic/hormone function then its perhaps not desirable.

 

[Sicknature]

ive read his book and was excited at first about many things such as resveratol etc.

however i think to have found out somewhere at some point that he uses botox, dyes his hair and is involved in massive conflict of interests among other things.

the reality about longevity is that noone has figured it out yet and thoose who claim they have have to prove it in the next 50-100 years. the question is also at what cost does the longevity come. if it doesnt come with health and youthfull metabolic/hormone function then its perhaps not desirable.

Wow, you're right:
View: https://www.youtube.com/watch?v=rdMWW-UgHJ0


He's a salesman

 

[Sicknature]

Wow, you're right:
View: https://www.youtube.com/watch?v=rdMWW-UgHJ0


He's a salesman

 

[Candeias]

What was this stuff Mr Ray Peat was saying about Omega 3 fish oil increasing the probability of diabetes?

“"Despite the nutritional value of those vitamins, fish oils are generally much more immunosuppressive than the seed oils, and the early effects of fish oil on the “immune system” include the suppression of prostaglandin synthesis, because the more highly unsaturated long chain fats interfere with the conversion of linoleic acid into arachidonic acid and prostaglandins. The prostaglandins are so problematic that their suppression is helpful, whether the inhibition is caused by aspirin or vitamin E, or by fish oil."” Ray Peat

I think this is why many Longecity users encourage the use of fish oil.

 

[ddjd]

David Sinclair’s Anti-Aging Supplement List 2022 – Food Security

Would like everyone's thoughts on this? Did Raypeat have many views on supplements and did he take any?

View: https://twitter.com/TexasLindsay_/status/1632597837237166081?s=20