Dietary Nitrates Can Cause Mania After Just Two Weeks Of Consumption

[Travis]

Sure, but...

...by regulating the cytokine gamma-interferon...

...[⁈]

 

[MrSmart]

Sure, but......[⁈]

We know that INF-y induces transcription of the cyclooxygenase genes, but there is also evidence that aspirin inhibits serine and tyrosine phosphorylation of STATs 1-3, and possibly STATs 4-6, which may explain why low-dose aspirin reduces COX-2 inflammatory activity slightly more than is explained by its pharmacokinetics.

 

[Amazoniac]

Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger (posted on the B12 thread)

 

[Obi-wan]

I think the reluctance to publish anything on the ammonia->cancer link is strongly influenced by the fear of implicating NO as harmful. The doctors were right, entire branches of medicine rest on the assumption that NO is beneficial and tons of money are ties to NO-boosting drug sales.

As I mentioned on another thread secretly adding ammonia made Marlboro the number 1 selling cigarette in the 70's. This was the smoking gun that led the states to sue Phillip Morris because in their internal memos it was discovered by their scientists to be a direct cause to lung cancer

 

[Obi-wan]

Yes, histamine is a big issue with aged anything. Even cheeses. Also, aged meat has a lot of endotoxin as even a lot of salt will not completely stop bacteria from metabolizing some of it.

But Histamine is involved with gastric acid release...

Gastric acid release[edit]
Enterochromaffin-like cells, located within the gastric glands of the stomach, release histamine that stimulates nearby parietal cells by binding to the apical H2 receptor. Stimulation of the parietal cell induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the parietal cell, the carbonic acid readily dissociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the bloodstream, while the hydrogen ions are pumped into the lumen of the stomach via a K+/H+ ATPase pump. Histamine release is halted when the pH of the stomach starts to decrease. Antagonist molecules, like ranitidine, block the H2 receptor and prevent histamine from binding, causing decreased hydrogen ion secretion. - Wikipedia

 

[MrSmart]

But Histamine is involved with gastric acid release...

Gastric acid release[edit]
Enterochromaffin-like cells, located within the gastric glands of the stomach, release histamine that stimulates nearby parietal cells by binding to the apical H2 receptor. Stimulation of the parietal cell induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the parietal cell, the carbonic acid readily dissociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the bloodstream, while the hydrogen ions are pumped into the lumen of the stomach via a K+/H+ ATPase pump. Histamine release is halted when the pH of the stomach starts to decrease. Antagonist molecules, like ranitidine, block the H2 receptor and prevent histamine from binding, causing decreased hydrogen ion secretion. - Wikipedia

That's H2.

 

[Obi-wan]

Histamine H2 receptor: Primarily involved in vasodilation and stimulation of gastric acid secretion. Modulates gastrointestinal function. -Wikipedia

 

[haidut]

But Histamine is involved with gastric acid release...

Gastric acid release[edit]
Enterochromaffin-like cells, located within the gastric glands of the stomach, release histamine that stimulates nearby parietal cells by binding to the apical H2 receptor. Stimulation of the parietal cell induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the parietal cell, the carbonic acid readily dissociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the bloodstream, while the hydrogen ions are pumped into the lumen of the stomach via a K+/H+ ATPase pump. Histamine release is halted when the pH of the stomach starts to decrease. Antagonist molecules, like ranitidine, block the H2 receptor and prevent histamine from binding, causing decreased hydrogen ion secretion. - Wikipedia

True, but if eating a very aged cheese or meat gives people an allergic reaction you are probably getting a lot more histamine than is needed for gastric acid. Also, typically we have plenty of histidine floating around so we can make histamine when we need it. Low gastric acid is usually driven by low CO2, not low histamine, and CO2 depends on metabolism. Search the forum for "CO2 gastric acid".

 

[Obi-wan]

" CO2 depends on metabolism." and can be increased by ingestion of Baking Soda or apple cider vinegar/ baking soda mix.

Many people take antiacids and antihistamines...

 

[kitback]

So am I to understand that my love affair with bacon and hot dogs could be contributing to my ongoing battle with sleep issues? ( I can only sleep for two or three hours at a time at random times of the day and night.)

 

[MrSmart]

So am I to understand that my love affair with bacon and hot dogs could be contributing to my ongoing battle with sleep issues? ( I can only sleep for two or three hours at a time at random times of the day and night.)

Processed meat and poultry is up there with vegetable oil as one of the worst things you can commonly eat. You can maybe have cold pressed turkey or chicken breast since they are almost zero fat and usually have no nasty preservatives.

 

[Obi-wan]

I visit my mother in South Jersey and drink her public water through a Brita filter. I wondered why I do not feel right when I visit her. Then she showed me a letter from the Township about the water being high in nitrates from fertilizer runoff...they said they will need to dig a deeper well

 

[Obi-wan]

So am I to understand that my love affair with bacon and hot dogs could be contributing to my ongoing battle with sleep issues? ( I can only sleep for two or three hours at a time at random times of the day and night.)

Try no nitrate bacon and dogs...

 

[inthedark]

An FYI for anyone here from Canada: Canadian law requires the use of nitrates in cured meats

 

[Vinero]

I remember a few years back I was at this party and was feeling a bit tired and introverted, even after a couple of beers I felt sluggish. Then suddenly someone put cheese sticks on the table.. I was quite hungry so I ate a large amount. Suddenly I became extremely talkative and energetic and couldn't stop talking to people. I went from introvert to extrovert, it was like I had taken speed or something. From then onwards I always considered cheese an energizing protein, but maybe it's simply the nitrates which all cheeses in the Netherlands have as a preservative.
I have completely stopped eating any cheese the last week, and I have to say I feel a lot calmer. It's like I have taken magnesium for the first time or an NMDA antagonist like low dose alcohol or adamantane. This leads me to believe that nitrates or nitric oxide are excitatory and stimulate NMDA receptors.
I always thought because cheese is high in calcium, and calcium increases dopamine, that explains why cheese makes me feel energetic. But maybe it isn't the calcium which makes cheese an energizing protein source. Maybe it's the nitrates which cause a slightly manic condition. Milk doesn't have the same energetic feeling as cheese does.

 

[Vinero]

I've been searching for nitrate content of foods but there is not much information on it, except that processed meats, some cheeses, vegetables like spinach and beets are rich in nitrates.

So does anyone know which foods are safe/very low in nitrate? I have noticed a great change in how I feel last week since I've stopped eating cheese which had added sodium nitrate as an additive.
Are milk, dark chocolate, orange juice, fresh meats like chicken breast, potatoes, white rice etc. safe? These are my main dietary staples now.

 

[Waynish]

Does this include red wine?

 

[Vinero]

Seems like nitrates seem to alter the type of gut flora: "the manic rats, the ones with nitrate in their diet, had different kinds of bacteria living in their guts than the control rats did".
I think cocoa can reverse this process and increase the proportion of harmless bacteria.
Cocoa Positively Modulates The Gut Microbe And Lowers TLRs And Inflammation

So avoid all nitrate containing foods like processed meats and cheese. Look at the labels, and do not buy foods which have sodium nitrate, sodium nitrite, potassium nitrate, and potassium nitrite as additives. Also avoid foods naturally high in nitrates such as most vegetables, especially spinach and beets.
Eat dark chocolate or cocoa powder to increase the good bacteria and lower inflammation markers

 

[Wagner83]

Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant. - PubMed - NCBI

 

[Wagner83]

.

 

[Frankdee20]

Would using Horny Goat Weed or Icariin supplements be as bad as Viagra ? That herb is a mild PDE5 inhibitor