Tristan Loscha
Member
- Joined
- Dec 18, 2018
- Messages
- 2,206
Healthnatura 1mg/drop
is it mk4,or mk7.
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Healthnatura 1mg/drop
mk4is it mk4,or mk7.
You mean, as opposed to topically?yes,then dose is good,if you take it orally (you should).
You mean, as opposed to topically?
My take as well. If it's a good quality why not orally. I usually drop vit D and vit K under the tongue along with pregnenolone in the eveningyes.topical absorption is iffy i guess.
This is a good oral dose though.
My take as well. If it's a good quality why not orally. I usually drop vit D and vit K under the tongue along with pregnenolone in the evening
Seems to make sense, and aren't most studies based on oral for safety purposes. Never have been quite convinced about topical absorption efficacy on many supplements.Yes.
A lot of data available has per os oral as administration, so its a known quantity.
Seems to make sense, and aren't most studies based on oral for safety purposes. Never have been quite convinced about topical absorption efficacy on many supplements.
@ScurveDream I can't say for sure but it happened to me when I first used it (k2 mk4) and disappeared after taking more milk, so maybe calcium related. Someone else had a similar issue: K2 Causing Heart Palpitations
Poison A, Venom D, Toxi-K. What about Biohazards 1,2,3,5 and 12? Can it be taken with Asmorbid acid @Amazoniac ?
Abstract said:Ubiquinone (UQ), a.k.a. coenzyme Q, is a redox-active lipid that participates in several cellular processes, in particular mitochondrial electron transport. Primary UQ deficiency is a rare but severely debilitating condition. Mclk1 (a.k.a. Coq7) encodes a conserved mitochondrial enzyme that is necessary for UQ biosynthesis. We engineered conditional Mclk1 knockout models to study pathogenic effects of UQ deficiency and to assess potential therapeutic agents for the treatment of UQ deficiencies. We found that Mclk1 knockout cells are viable in the total absence of UQ. The UQ biosynthetic precursor DMQ9 accumulates in these cells and can sustain mitochondrial respiration, albeit inefficiently. We demonstrated that efficient rescue of the respiratory deficiency in UQ-deficient cells by UQ analogues is side chain length dependent, and that classical UQ analogues with alkyl side chains such as idebenone and decylUQ are inefficient in comparison with analogues with isoprenoid side chains. Furthermore, Vitamin K2, which has an isoprenoid side chain, and has been proposed to be a mitochondrial electron carrier, had no efficacy on UQ-deficient mouse cells. In our model with liver-specific loss of Mclk1, a large depletion of UQ in hepatocytes caused only a mild impairment of respiratory chain function and no gross abnormalities. In conjunction with previous findings, this surprisingly small effect of UQ depletion indicates a nonlinear dependence of mitochondrial respiratory capacity on UQ content. With this model, we also showed that diet-derived UQ10 is able to functionally rescue the electron transport deficit due to severe endogenous UQ deficiency in the liver, an organ capable of absorbing exogenous UQ.
LeeLemonoil said:Lethalene Blue