Effects of oral coenzyme Q10 on preventing the accumulation of lactic acid developing during the exercise performances of endurance skiing athletes
CoQ10 levels are often reduced in people who do a lot of exercise, people who take statins.
300mg+ may interfere with exercise adaptation. but 100mg could be beneficial for performance, and reducing lactate.
it takes some tissues like heart tissue a month or 2 to see an increase and benefits from a daily supplement
but in this case the response is acute
in diabetes , 100mg coq10 helps fasted blood sugar & hba1c (100mg is enough to see mitochondria function gain & oxidation protection) they say the hba1c drop couldnt be attributed to q10. but likely was Effects of coenzyme Q10 supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
another study for 8 weeks 100mg, only slight reduction in MDA levels, no change in outcomes. <---- by this it would take 12 weeks to see an improvement in diabetes
also helps protect against toxicity of toxic metals
In the human, coenzyme Q10 (vitamin Q10) is biosynthesized from tyrosine through a cascade of eight aromatic precursors. These precursors indispensably require eight vitamins, which are tetrahydrobiopterin, vitamins B6, C, B2, B12, folic acid, niacin, and pantothenic acid as their coenzymes. Three of these eight vitamins (the coenzyme B6, and the coenzymes niacin and folic acid) are indispensable in the biosynthesis of the four bases (thymidine, guanine, adenine, and cytosine) of DNA. One or more of the three vitamins required for DNA are known to cause abnormal pairing of the four bases, which can then result in mutations and the diversity of cancer. The coenzyme B6, required for the conversion of tyrosine to p-hydroxybenzoic acid, is the first coenzyme required in the cascade of precursors. A deficiency of the coenzyme B6 can cause dysfunctions, prior to the formation of vitamin Q10, to DNA. Former data on blood levels of Q10 and new data herein on blood levels of B6, measured as EDTA, in cancer patients established deficiencies of Q10 and B6 in cancer. This complete biochemistry relating to biosyntheses of Q10 and the DNA bases is a rationale for the therapy of cancer with Q10 and other entities in this biochemistry.
Administration of Q10 significantly reverses exercise-induced abnormalities of oxidative phosphorylation of the brain of patients with known mitochondrial enzyme defects.
The therapeutic efficacy of CoQ10 is not restricted to patients with an underlying CoQ10 deficiency and is thought to result from its ability to restore electron flow in the mitochondrial respiratory chain (MRC) as well as to increase the cellular antioxidant capacity
CoQ10 levels are often reduced in people who do a lot of exercise, people who take statins.
300mg+ may interfere with exercise adaptation. but 100mg could be beneficial for performance, and reducing lactate.
it takes some tissues like heart tissue a month or 2 to see an increase and benefits from a daily supplement
but in this case the response is acute
in diabetes , 100mg coq10 helps fasted blood sugar & hba1c (100mg is enough to see mitochondria function gain & oxidation protection) they say the hba1c drop couldnt be attributed to q10. but likely was Effects of coenzyme Q10 supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
another study for 8 weeks 100mg, only slight reduction in MDA levels, no change in outcomes. <---- by this it would take 12 weeks to see an improvement in diabetes
also helps protect against toxicity of toxic metals
In the human, coenzyme Q10 (vitamin Q10) is biosynthesized from tyrosine through a cascade of eight aromatic precursors. These precursors indispensably require eight vitamins, which are tetrahydrobiopterin, vitamins B6, C, B2, B12, folic acid, niacin, and pantothenic acid as their coenzymes. Three of these eight vitamins (the coenzyme B6, and the coenzymes niacin and folic acid) are indispensable in the biosynthesis of the four bases (thymidine, guanine, adenine, and cytosine) of DNA. One or more of the three vitamins required for DNA are known to cause abnormal pairing of the four bases, which can then result in mutations and the diversity of cancer. The coenzyme B6, required for the conversion of tyrosine to p-hydroxybenzoic acid, is the first coenzyme required in the cascade of precursors. A deficiency of the coenzyme B6 can cause dysfunctions, prior to the formation of vitamin Q10, to DNA. Former data on blood levels of Q10 and new data herein on blood levels of B6, measured as EDTA, in cancer patients established deficiencies of Q10 and B6 in cancer. This complete biochemistry relating to biosyntheses of Q10 and the DNA bases is a rationale for the therapy of cancer with Q10 and other entities in this biochemistry.
Administration of Q10 significantly reverses exercise-induced abnormalities of oxidative phosphorylation of the brain of patients with known mitochondrial enzyme defects.
The therapeutic efficacy of CoQ10 is not restricted to patients with an underlying CoQ10 deficiency and is thought to result from its ability to restore electron flow in the mitochondrial respiratory chain (MRC) as well as to increase the cellular antioxidant capacity
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