Bromantane reduces liver fibrosis by 60%, kidney fibrosis by 50%

[Mauritio]

This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis.
I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not true.
The 60% fibrosis reduction came from a HED of 200-300mg of bromantane . Definitely on the higher side, but achievable . Especially given the fact hat there's is no medication currently approved to treat liver fibrosis.

Now they also tested a lower dosage which still came down to a 42% reduction in liver fibrosis.
This dosage had a HED of only 100-150mg !

This article mentions that bromantane also reduced chronic kidney fibrosis by more than 50%.
(Algernon Pharmaceuticals Announces Russian Athletic Performance Enhancing Drugs Bemethyl (NP-135) and Bromantane (NP-160) Exhibited Potent Anti-Fibrotic Activity in NASH and CKD Studies)

This was more than 2 years ago and unfortunately I couldnt find any updates on those clinical trials. Which might be a blessing in disguise, as they're of course trying to make it into a licensed medication, which would make it a lot harder to source and use for the generell population.


Look at the file below . Bromantane is NP-160.
Btw the other compound that was even more effective (80% reduction in liver fibrosis) was bemethyl ,another very interesting actoprotector by the Russians.

 

[Mauritio]

Bromantane seems to be anti-endotoxin and anti-inflammatory too .

Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome - PubMed

The effects of ladasten and reference product imipramine (10 mg/kg) on the content of cytokines TNF-α, IL-6, IL-10, IL-1α, IL-2, IL-4, IL-5, IL-17, IFN-γ, and GM-CSF and behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal...

pubmed.ncbi.nlm.nih.gov

[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice] - PubMed

Effects of the antiasthenic drug ladasten [N-(2-adamantyl)-N-(para-bromophenyl)amine] on the profile of cytokines, behavior, and indexes of immunity organs was studied on zoosocial stress model in depressed C57BL/6 male mice. The anxious depression state in male mice was formed by repeated...

pubmed.ncbi.nlm.nih.gov

 

[cjm]

This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis.
I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not true.
The 60% fibrosis reduction came from a HED of 200-300mg of bromantane . Definitely on the higher side, but achievable . Especially given the fact hat there's is no medication currently approved to treat liver fibrosis. View attachment 23464

Now they also tested a lower dosage which still came down to a 42% reduction in liver fibrosis.
This dosage had a HED of only 100-150mg !

View attachment 23465

This article mentions that bromantane also reduced chronic kidney fibrosis by more than 50%.
(Algernon Pharmaceuticals Announces Russian Athletic Performance Enhancing Drugs Bemethyl (NP-135) and Bromantane (NP-160) Exhibited Potent Anti-Fibrotic Activity in NASH and CKD Studies)

This was more than 2 years ago and unfortunately I couldnt find any updates on those clinical trials. Which might be a blessing in disguise, as they're of course trying to make it into a licensed medication, which would make it a lot harder to source and use for the generell population.


Look at the file below . Bromantane is NP-160.
Btw the other compound that was even more effective (80% reduction in liver fibrosis) was bemethyl ,another very interesting actoprotector by the Russians.

Russians right again! Nice post. Would love to see more on bemethyl:

 

[Aad]

What dosage of bemethyl? And will it also work against kudney fibrosis?

 

[Mauritio]

What dosage of bemethyl? And will it also work against kudney fibrosis?

The dosage seemed very high about 1,3g for a human. And yes also for kidney fibrosis.

Russians right again! Nice post. Would love to see more on bemethyl:

View attachment 23479

Yes, they make it seem so easy haha .
I was reading up on it a few months ago ,but a forum member told me he didnt feel much from it and I found much more reports from people who took bromantane ,that's why I went with this one.

@Lokzo Made a post about it on his website .
I think it is the original actoprotector .

Bemethyl (Synthetic Adaptogen) - Boost Your Biology

Developed in the Soviet Union for the needs of the military, Bemitil (also known as Metaprot and AntiHot) has a long history of usage in clinical practice and in sport. It was developed in the 1970s and was successfully used during Afghanistan war, Chernobyl catastrophe and Olympic games in Moscow.

www.ergogenic.health

 

[Aad]

Thanks bro!

 

[Mauritio]

"The data obtained suggest that the positive effect of bromantan on the physical efficiency is associated not only with its psychostimulating action but also with the membrane-protecting effect."

[The effect of bromantane on the physical work capacity of laboratory animals] - PubMed

The positive effect of bromantan (0.5-50 mg/kg) on the efficiency of physical work of mice and rats (swimming test, running on a treadmill) exceeds that of phenamine administered in optimal doses by 1.3-1.6 times. Such an effect of bromantan lasts no less than 24 h. The drug delays decrease of...

pubmed.ncbi.nlm.nih.gov

 

[Bart1]

thanks Mauritio, appreciate the work!

 

[Mauritio]

Thanks bro!

thanks Mauritio, appreciate the work!

No problem :)

 

[Mauritio]

So bromantane not only increases dopamine via increasing tyrosine hydroxilase, but also it's a SDRI (selective dopamine reuptake inhibitor) !
While not influencing serotonin levels directly.
(Indirectly lowering it through dopamine's TPH inhibiton )


"Ladasten in a single dose of 50 mg/kg (i.p.) stimulated ex vivo dopamine biosynthesis and release in striatum, without any influence on serotonin formation neither in striatum nor in frontal cortex."

"Both ladasten and sydnocarb inhibited the active transport of dopamine in rat striatal synaptosomes at IC50 = 3.56 microM and 28.66 nM, respectively, but failed to influence the serotonin re-uptake in rat frontal cortex."

[Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb] - PubMed

The influence of ladasten and sydnocarb on dopamine and serotonin receptors and the biosynthesis and re-uptake of dopamine and serotonin has been studied. It is established that both drugs do not produce any direct effects on dopamine D1, D2, and D3 receptors in rat striatum as well as on...

pubmed.ncbi.nlm.nih.gov

 

[Mauritio]

Also on reddit I have read multiple times that the anti-cholinergoc activity is only active in super high doses (they are afraid that anti-cholinergics cause alzheimers) ,which seeks to be false. Actually the lower dosages of a human equivalent of 400mg was more anticholinergic than the super high dosage of 800mg.
It actually seems to be cholinergic in super high and in normal or high doses anti-cholinergic .

"Behavioral effects of bromantane in doses of 30 and 600 mg/kg were associated with stimulation of the central dopamine and suppression of muscarinic and nicotinic cholinergic structures, n-cholinolytic effects of bromantane was more pronounced at a dose of 30 mg/kg than at a dose of 600 mg/kg."

"Cholinergic components of the neurotropic effect of:bromantane are poorly expressed and manifest at high doses [3]"

Toxic effect of single treatment with bromantane on neurological status of experimental animals - PubMed

Neurotoxicological profile of actoprotector bromantane was studied on rats using S. Irwin's protocol of multi-test observation. The drug in doses of 30-300 mg/kg stimulated and in doses of 600-9,600 mg/kg suppressed behavioral activity. Spontaneous motor activity increased after single treatment...

pubmed.ncbi.nlm.nih.gov

 

[grithin]

Behavioral effects of bromantane in doses of 30 and 600 mg/kg were associated with stimulation of the central dopamine and suppression of muscarinic and nicotinic cholinergic structures, n-cholinolytic effects of bromantane was more pronounced at a dose of 30 mg/kg than at a dose of 600 mg/kg

This was my experience when I tested it years ago. Greater willingness to act (more dopamine) towards unwise things (less choline) (dosing from, if I recall, ~60mg to 300mg)

 

[Mauritio]

towards unwise things (less choline)

So you attribute this to less acetylcholine ?

 

[grithin]

So you attribute this to less acetylcholine ?

At the time, I just attributed it to increased dopamine resulting in faster (less thought through) more impulse driven decision making. But the reaction could also be explained by an accompanying drop in information processing.

suppression of {muscarinic and nicotinic cholinergic structures}, [and] n-cholinolytic effects of bromantane

 

[Mauritio]

At the time, I just attributed it to increased dopamine resulting in faster (less thought through) more impulse driven decision making. But the reaction could also be explained by an accompanying drop in information processing.

Oh okay I didn't know you were just speculating.
I thought maybe that's a generell thing that I haven't heard about.

 

[GorillaHead]

Anyone else experimenting with bromantane. I just ordered some on the way this week.
I really am curious about the effects on skin. Peripheral Blood flow

 

[Ismail]

Anyone else experimenting with bromantane. I just ordered some on the way this week.
I really am curious about the effects on skin. Peripheral Blood flow

How you getting on with Bromantane @GorillaHead ?

 

[GorillaHead]

How you getting on with Bromantane @GorillaHead ?

I tried it in acute phases. Way better than caffiene. Sleep is good. Mild withdrawls the next day. I did not notice any permanent effects.

 

[Aad]

Interesting to find out if it also works for pulmonary fibrosis.