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Anti-adrenaline Drugs Like Clonidine May Prevent Diabetes Type I

Discussion in 'Scientific Studies' started by haidut, Feb 20, 2018.

  1. haidut

    haidut Member

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    Peat mentioned a few times that the pancreatic damage seen in type I diabetes is caused by prolonged exposure to PUFA, as unsaturated fats are toxic to the insulin-producing beta cells in that organ. Many of the cases of new onset diabetes I occur after a period of extreme exhaustion and/or fasting and/or stress/illness, which invariably results in elevation of FFA. The primary mechanism for FFA elevation is adrenaline (even though estrogen can also cause lipolysis independently of adrenaline). This new study found that anti-adrenaline drugs of the class alpha adrenergic agonists - which include clonidine and the specific drug used (methyldopa) - can prevent the development of diabetes I and drastically reduce the severity of already established disease. The proposed mechanism of action is not lowering of adrenaline but silencing of the DQ8 antigen. However, the main mechanism of action of those drugs is reduction in adrenaline levels, and that mechanism of action was not assessed by the current study. So, until I see a study conclusively showing DQ8 is the exclusive mechanism of action, my assumption is that adrenaline is involved as well.


    JCI - Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes
    Common Blood Pressure Drug Found to Prevent Type 1 Diabetes | GEN
    "...The researchers report their findings in the Journal of Clinical Investigation, in a paper entitled “Methyldopa Blocks MHC Class II Binding to Disease-Specific Antigens in Autoimmune Diabetes.”
    T1D results from the chronic autoimmune-mediated destruction of insulin-producing beta-cells in the pancreatic islets, and while a number of immune therapies designed to slow or prevent beta-cell loss have been tested in clinical trials, “these therapies have shown limited clinical benefit to date,” the authors explain. For many autoimmune disorders, human leukocyte antigen (HLA) complex genes are associated with increased risk. In T1D, the HLA-DQ8 allele is present in 50% to 60% of all patients, and “confers significant disease risk and is involved in disease pathogenesis.” The authors hypothesized that blocking DQ8 antigen presentation might prevent the recognition of self-peptides by pathogenic T cells and so help to prevent the development of T1D in patients. They used the crystal structure of DQ8 to screen for small molecules that might bind to specific pockets within the protein’s structure and inhibit DQ8 antigen presentation. Tests in cell cultures and in the nonobese diabetic (NOD) mouse model of T1D showed that the candidate tetraazatricyclododecane (TATD) delayed the onset of diabetes and prevented disease in half of the treated mice. Starting TATD therapy when NOD mice had already developed more established disease led to maintenance of normal blood glucose and preserved glucose tolerance. “Overall, these data indicate that therapeutic blocking of MHC II antigen presentation in a spontaneous model of autoimmune diabetes prevents disease onset, blocks critical interactions between T and B cells, lessens tissue-specific destruction and maintains glucose tolerance when administered in later stages of diabetes development,” the team writes."
     
  2. Regina

    Regina Member

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    I think of DQ8 as "the celiac gene". (I was homozygous DQ8 on my 23nMe test). Maybe inosine or better yet, cardenosine, would be a great supplement for this.
     
  3. OP
    haidut

    haidut Member

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    Interesting, thanks for sharing. Does inosine help you?
     
  4. Regina

    Regina Member

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    I think so. But most of the awful things that kicked in when I had a series of nasty stressors are resolving.
    I was able to train 2 hrs after taking cardenosine last night. I have a seminar this weekend, so I will really be put to test.

    I think ketotifen, cardenosine, MB and energin plus electrolytes is a pretty awesome stack.
     
  5. lvysaur

    lvysaur Member

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    Reduction in adrenaline is generally a "progressive" or "privileged" trait, where animals that are under no threat evolve to be low-adrenaline, because they can afford to. This obviously signifies that adrenaline is bad unless there is something so threatening that you may need it.
     
  6. Regina

    Regina Member

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    I think haidut's recent post regarding contagious trauma points to how easily it is to radicalize groups.
     
  7. poilochio

    poilochio Member

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    I have a Typ 1 Diabetic Rat ...so i am very interested in this Info thank you Haidut . I'm wondering if a Idea Labs Product has a similar effect as Clonidine?
     
  8. OP
    haidut

    haidut Member

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    None that I am aware of since clonidine is specifically an alpha adrenergic agonist. However, inosine has been shown to have anti-adrenaline effects and has studies behind it for diabetes II. Not type I but the mechanism is actually similar and type II is basically a precursor to type I if left untreated.
     
  9. poilochio

    poilochio Member

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    Ok i will check it out ..thanks Haidut

    Btw really low fat and high carbs have reduced my rats Insulin needs drastically . I thought that only worked in typ 2 but obviously also in typ1
     
  10. OP
    haidut

    haidut Member

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    Good to hear. Yeah, type I seem to be just a more extreme version of type II, with really high lipolysis. As such, sugar, aspirin and B3 should help for type I too.
     
  11. poilochio

    poilochio Member

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    I actually made a topical solution last summer of Aspirin, B1 ,B3, B7 and ribovlavin b2 but it freaked me out because it dropped the Sugar levels so low that i had to fight the whole night to keep them up and it was exhausting .I will repeat the experiment for sure with lower dose on a day where i won't give the Rat long-lasting Insulin
     
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