pufa

  1. Mauritio

    Serotonin, PUFA and histamine increase leaky brain

    This is just just another angle showing how stress hormones and PUFA affect the whole body negatively. Increased Blood-brain-barrier permeability(leaky brain) is linked to many diseases : "Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including...
  2. shine

    Effects of dietary fatty acids on the social life of male Guinea pigs from adolescence to adulthood

    https://pubmed.ncbi.nlm.nih.gov/32504693/ "Dietary intake of polyunsaturated fatty acids (PUFAs) or saturated fatty acids (SFAs) differently modulates neurophysiological and behavioral functions in response to altered hypothalamic-pituitary-adrenal (HPA)-axis...
  3. pauljacob

    Which has more PUFA: Yolk or White?

    I searched online but didn't get an answer. I'd appreciate any response.
  4. haidut

    Maternal high-PUFA diet causes alcoholism, aggressiveness, early puberty, and hyper-estrogenism in offspring

    Finally, an intervention study that should help convince some of the die-hard PUFA fans that these fatty acids are far from benign/beneficial, but in fact can cause a variety of chronic diseases. A very important finding of the study, that distinguishes it from other PUFA studies, is that it...
  5. haidut

    Air pollution impairs cognition, aspirin is protective

    A new study demonstrating that even short-term (less than a month) exposure to polluted air impaired cognition in humans, and that the mechanism of action was by triggering an inflammatory response. Ergo, anti-inflammatory drugs (NSAID) and especially aspirin, were found to be protective. Since...
  6. haidut

    Inflammation (from PUFA), not telomeres, determines lifespan / healthspan

    The idea of lifespan being entirely determined by limits on cellular division has ruled biology for more than a century and is perhaps best exemplified by the (in)famous (and false) Hayflick limit. Reaching the said limit is postulated to be controlled by telomere length, and as such the...
  7. E

    Sterculia oil, SCD1 and inflammation

    To my surprise I didnt find a post on this so I figured I'd make one, because I want to know your opinions. So many of us know Brad Marshall for his Croissant diet, a diet high in stearic acid. Recently he has been researching and writing a lot about the role of the enzyme SCD1 which regulates...
  8. Mauritio

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity: This is probably one of the most interesting papers I've read in a long time . It goes into depth about the danger of PUFA and conncects the dots between PUFA ,membranes ,rate of living theory, life expectancy, and...
  9. A

    Https://news.osu.edu/omega-3-supplements-do-double-duty-in-protecting-against-stress/

    Omega-3 supplements do double duty in protecting against stress
  10. egoy

    Brain Cancer stage 4 glioblastoma giant cells. What options are available?

    This is about a family member. She is 56yo. This morning she was diagnosed with head cancer... doctors gave her a short term to live. They want to put her on chemotherapy. What can i do for her ? Is there any way possible to reverse this ? @haidut @mrchibbs @Tarmander
  11. haidut

    PUFA metabolites may drive bacterial infections and their resistance to antibiotics

    The study below demonstrates yet again that there is hardly an aspect of human health that PUFA does not influence in a detrimental manner, even seemingly non-metabolic aspects such as bacterial infections. As it turns out, most bacteria express the enzyme family known as lipoxygenases (LOX) and...
  12. haidut

    DHT / Progesterone / aspirin treat, cortisol ineffective, PUFA promotes prostate cancer

    A great study, albeit in-vitro, that once again throws into doubt the entire hypothesis behind prostate cancer. First, it proves the key role of PUFA in the genesis and progression of prostate cancer by demonstrating that inhibitors of the COX enzyme (responsible for synthesizing prostaglandins...
  13. Grapelander

    Dr. Chris Knobbe - 'Diseases of Civilization: Are Seed Oil Excesses the Unifying Mechanism?'

    Nothing new for this group - nice to see more recognition of the PUFA topic; a decent presentation as well. Dr. Chris Knobbe is an ophthalmologist and Associate Clinical Professor Emeritus, formerly of the University of Texas Southwestern Medical Center, in Dallas, Texas. He is also the...
  14. Hans

    How to lose fat safely while Peating

    This is a frequent topic on the forum. What about fat loss and fatty acid oxidation, glucuronidation, cortisol, thyroid, etc? All are discussed in the article. How to lose fat safely while Peating
  15. metabolizm

    Is Google pro-PUFA?

    I decided to type "polyunsaturated fat" into Google today, and literally every link on the first page of the search results (including PubMed studies) was decidedly pro-PUFA and anti-SFA. It's not until somewhere down on page two that we see something else: an article from Harpers Bazaar...
  16. haidut

    Glucocorticoids may increase inflammation in the long run

    Glucocorticoids (both bioidentical and synthetic) are some of the most widely used drugs in the clinical setting, as well as in outpatient treatment for all sorts of ailments - i.e. autoimmune conditions, joint pain, post-operative inflammation, asthma, and even infectious diseases such as...
  17. haidut

    PUFA promote torpor / hibernation, decrease lifespan

    Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly...
  18. haidut

    PUFA are potent immunosuppresive agents

    Just a quick post for all those PUFA/fish-oil lovers who keep sending me hate-mail about the "incredibly beneficial" omega-3, and even omega-6 (e.g. some athletes/bodybuilders tout arachidonic acid as a natural "anabolic agent"). As the study below discusses, all PUFA, but especially omega-3...
  19. haidut

    Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

    The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is "essential". Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the...
  20. haidut

    Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

    Yet another study implicating the great villain of systemic health - endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of...
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