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  1. haidut

    Replacing starch with sucrose increases metabolism, prevent obesity

    A study that will certainly generate controversy in the low-carb blogosphere, but the findings are hard to dispute. Namely, feeding a diet for 15 weeks, in which 74.3% of the calories come from carbs in the form of starch was clearly obesogenic, caused insulin resistance and elevated blood...
  2. haidut

    Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

    The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...
  3. haidut

    Keto Diet Can Cause Lethal Kidney Failure

    The bad news for the low-carb diets just keep piling on. This case report is about a young and (presumably) healthy Indian actress, which quickly deteriorated and eventually died of kidney failure while subjecting herself to the keto diet. Before the hate mail starts pouring into my mailbox...
  4. haidut

    Lipolysis / FFA Drive Breast Cancer By Promoting Estrogen Signalling

    The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...
  5. haidut

    Simply Diluting "old Blood" Has The Same Anti-aging Effects As Parabiosis

    The topic of using blood from young people to stave off aging and disease is hardly new. Rumors have been circulating for centuries that the old and rich use all kinds of gruesome methods to acquire blood from young people and use that blood for all sorts of bizarre rejuvenating procedures...
  6. haidut

    COVID-19/SARS May Be Due Simply To Serum PUFA And Its Peroxidation

    During the last podcast with Danny Roddy, Dr. Peat and I discussed the role of elevated free fatty acids (FFA) in the blood as facilitators of viral infection. I opined that the hydrophilic nature of PUFA circulating in the blood increases the permeability of cells and allows for easier viral...
  7. haidut

    Fibromyalgia May Be Simply A Sign Of Insulin Resistance

    As many of your have seen on TV, there is currently a boom in ads for drigs to treat fibromyalgia. This condition is yet another one of mysterious origins, at least according to mainstream medicine. The treatment consists mainly of GABA agonists like Lyrica but the official version is (of...
  8. haidut

    Sterilizing The Gut Restores Insulin Sensitivity By Reducing Fatty Acid Oxidation

    I am posting this study just as an example of how important the role of endotoxin is in insulin resistance and diabetes. Similarly to the human study with aspirin, sterilizing the gut with antibiotics did not reduce the weight in the obese subjects (in this case mice). So, obesity may be a less...
  9. haidut

    Adrenaline (epinephrine) Damages The Brain

    Adrenaline injections directly into the heart are the only currently approved treatment for cardiac arrest. It is considered the patient's only chance of revival and recovery. However, observational trials over the year have noticed that cardiac arrest survivors often have severe neurological...
  10. haidut

    Fats Cause Cause Cognitive Impairment And Insulin Resistance In The Brain

    The topic of whether fats cross the BBB is very controversial, especially in light of recent evidence that dementias like Alzheimer are simply so-called "diabetes of the brain". It is well-known in clinical circles that fats do cause insulin resistance, but the PUFA lobby is powerful enough to...
  11. haidut

    Anti-adrenaline Drugs Like Clonidine May Prevent Diabetes Type I

    Peat mentioned a few times that the pancreatic damage seen in type I diabetes is caused by prolonged exposure to PUFA, as unsaturated fats are toxic to the insulin-producing beta cells in that organ. Many of the cases of new onset diabetes I occur after a period of extreme exhaustion and/or...
  12. P

    IGF-1

    Here probably i only post positives about igf1, as ray seeing it generally on reparative ,constructive side.(according to danny roddy,thanks to him) it is interesting most nutrient deficiencies lower igf1 but not GH! Hypothyroids have lower level of igf1...
  13. haidut

    Delirium (and Dementia/AD) Is Caused By Inability To Oxidize Glucose

    Ray has written about the metabolic origins of Alzheimer disease (AD) and I posted quite a few studies on the links between AD and PUFA metabolites as well as insulin resistance in the brain. I even mentioned on one of Danny Roddy's shows that there is a proposal by NIH to reclassify AD as...
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