I have absolutely tanked catecholamines and probably serotonin as well.
I’ve tried so many things, just nothing gives me pleasure. Had urine and blood catecholamine test and all 3 of my Levels were non existent. My dr said he never seen it. It matches up with my genetics as I have the FAST COMT gene. I have fast activity and burn through my catecholamines too quick leaving me with low levels.
To get to the point does anyone have information on the DDC gene .It makes the enzyme aromatic l-amino acid decarboxylase.
This enzyme is responsible for BOTH the conversion of tyrosine to dopamine and tryptophan to serotonin. I have SEVERAL homogeneous mutations for it. And overall mutations for dopamine and serotonin. In the 99%. This is a very new unique genetic testing.
Even if you dont really believe genetics can you give me some thought please? I believe epigenetic trump, but my genetics/blood/ symptoms are all adding up.
So I can obviously bring dopamine boosting things into the picture , but does that even do anything being the enzyme that does the final conversion is mutated ? Would it make it worse ?
How can I boost the ENZYME that does the conversion rather then just boost dopamine. Or would adding tyrosine etc be best? It’s not like the enzyme is broken, so maybe just my natural Dopamine/combined w mutated enzyme isn’t enough? And if I add in some exogenous dopamine I can get some symptom relief ? I’m not sure if increasing dopamine or fixing the enzyme is the solution ? Although I don’t know how to go about fixing the enzyme. I guess just provide the right amino acids and minerals so it’s working it’s best.
My symptoms are bad. Can’t walk straight. Fall over left and right. Forget where I’m driving. Extreme dissociation. Only 25. I suspect very low serotonin too contrary to what others may think. Just low across the board.
I’ve tried so many things, just nothing gives me pleasure. Had urine and blood catecholamine test and all 3 of my Levels were non existent. My dr said he never seen it. It matches up with my genetics as I have the FAST COMT gene. I have fast activity and burn through my catecholamines too quick leaving me with low levels.
To get to the point does anyone have information on the DDC gene .It makes the enzyme aromatic l-amino acid decarboxylase.
This enzyme is responsible for BOTH the conversion of tyrosine to dopamine and tryptophan to serotonin. I have SEVERAL homogeneous mutations for it. And overall mutations for dopamine and serotonin. In the 99%. This is a very new unique genetic testing.
Even if you dont really believe genetics can you give me some thought please? I believe epigenetic trump, but my genetics/blood/ symptoms are all adding up.
So I can obviously bring dopamine boosting things into the picture , but does that even do anything being the enzyme that does the final conversion is mutated ? Would it make it worse ?
How can I boost the ENZYME that does the conversion rather then just boost dopamine. Or would adding tyrosine etc be best? It’s not like the enzyme is broken, so maybe just my natural Dopamine/combined w mutated enzyme isn’t enough? And if I add in some exogenous dopamine I can get some symptom relief ? I’m not sure if increasing dopamine or fixing the enzyme is the solution ? Although I don’t know how to go about fixing the enzyme. I guess just provide the right amino acids and minerals so it’s working it’s best.
My symptoms are bad. Can’t walk straight. Fall over left and right. Forget where I’m driving. Extreme dissociation. Only 25. I suspect very low serotonin too contrary to what others may think. Just low across the board.
