COVID-19: Prophylaxis With Low-dose L-Quinine; Ponder This?
The infection viral dose is currently estimated at 100 virions. The amount of a prophylactic antiviral blocker at this stage would theoretically then be very low. L-quinine may be more potent and...
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Discussion
Started 9th Apr, 2020
Gary Joseph Ordog
COVID-19: Prophylaxis With Low-dose L-Quinine; Ponder This?
The infection viral dose is currently estimated at 100 virions. The amount of a prophylactic antiviral blocker at this stage would theoretically then be very low. L-quinine may be more potent and effective than low dose hydroxychloroquine, considering the natural source of l-quinine contains the pure desired enantiomer, versus HCQ is synthetic and composed of four enantiomers that probably competitively inhibit the binding of the desired enantiomer. Thus 20mg (one glass of tonic water) may have more biological activity than 100mg of HCQ. Side-effects of 20mg appear to be nil to nonexistent, as million of people have imbibed this over the centuries. Obviously, one should get their physicians' advice on this. Another point is that there are billions of people on this who do not have readily available medical access, but they do have access to tonic water, or may already use it to prevent other viral and protozoal infections. Millions of people already do this chronically for prophylaxis, and the risk is low. For a placebo controlled double blind study to be done, this could take years, and is unlikely to be done because there is no large amount of money to be made anyway. Tonic water is a dollar a bottle and lasts for a week at this dose. Risk: Nil (if not contraindicated). Benefit: Possibly thaumaturgic!Most recent answer
4th Feb, 2021
Gary Joseph Ordog
County of Los Angeles Public Health
February 04, 2021: Quinine prophylaxis update; Anecdotal Study. Still not one infection out of 100 subjects on low dose prophylactic l-quinine (8 oz. tonic, approximately 20 mg l-quinine per day). Probably not publishable, but more of an interesting observation. Thank you.
21st May, 2020
Gary Joseph Ordog
County of Los Angeles Public Health
Yes, at least from a biochemistry point of view for prophylaxis, I think that natural l-quinine is better than synthetic, four enantiomer HCQ. 75% of the commercial product is stereoisomeric competitive inhibitor, versus 0% from l-quinine the natural product. This may be why malaria responds to l-quinine, but develops resistance to racemic HCQ. Much less l-quinine is required, so fewer side effects. In our experience, 20 mg of l-quinine has better prophylactic antiviral effect than 100 mg of racemic HCQ. (synthetic with 4 enantiomers, one effective and 3 competitive inhibitors).(This is anecdotal and theoretical information at present)
10th Aug, 2020
Gary Joseph Ordog
County of Los Angeles Public Health
Okay, for a lesson on anecdotal studies. Where I am staying, in April 2020 there was the first peak of the Pandemic locally, many sick with COVID-19 and many deaths, especially in the long-term care and nursing homes. When the virus first arrived here, and an emergency was declared by the President, I started using full PPE, and following all of the Public Health suggestions. I worked in Health Care for over 40 years, and dealt with infectious disease on a daily basis. So I personally thought I knew how to take care of it. I personally researched and reviewed all I could find on the Coronavirus, plus I read all of the journal articles on COVID-19 the day they were put on line. I determined that a good candidate for at least prevention, would be a combination of natural antiviral ingredients that I had available. The top one was a chemical that I knew very well, and knew that it had been safely used for hundreds of years, quinine. It was readily available as "tonic water" in a safe and low dose, that may be all that is needed to prevent the viral infection. I also knew, as a medical toxicologist, that it can be toxic, being a classic QTc prolongator, and many years ago it was used as a abortifacient, but currently was used widely as an immune suppressant for autoimmune diseases, and still generally regarded as safe. I also tested and saw that it could easily kill corona virus in vitro and in plants. (I also investigated others, such as resveratrol, lectins and leptins.) This was before there was any mention of HCQ or CQ by anyone else on line or in the news. I also knew, from a degree in Biochemistry that quinine was a natural product of a single correct stereoisomer, so I felt it was at least one factor (2^n) better than the synthetic HCQ and CQ that had numerous competitive inhibitors in the form of incorrect stereoisomers. I told all my friends, relatives to take a glass (20mg) a day, maybe it would help prevent the virus. I stocked up on tonic water and gave it out to people who needed it. We added foods rich in resveratrol, lectins and leptins, and the n-methylxanthines (tea, coffee, chocolate). so, the anecdotal study is that I don't know anyone personally who has been infected with the SARS-CoV-2. One of my aunts lives in a long-term care facility, where all the other 17 patients on her floor, and 4 staff members died of COVID-19, but she didn't even get the sniffles. So, anecdotal, and in this medical world it probably means nothing, it would never be published, except in a social media type report such as this. (Obviously, this small dose was not recommended to people who had contraindications, such as pregnancy or QTc prolongation, etc. The usual disclaimer, this has not been evaluated by the FDA, and is not promoted to treat any disease; only as a dietary supplement) I pray that our "luck" holds out until the good vaccine is delivered here. Thank you. August 09, 2020 Gary Ordog, MD.
21st Sep, 2020
Gary Joseph Ordog
County of Los Angeles Public Health
September 20, 2020 Update: Still no one that I know, including all my relatives, have had COVID-19 or even tested positive for mRNA SARS-CoV-2. As far as I know, they are still prophylaxing with l-quinine, although the individual compliance may be decreasing. I , for one noticed some GI cramping from just 6 oz. per day of commercial toxic water. I did switch to resveratrol in an approximately equal prophylactic dose. No illness so far and negative mRNAs. (ps Is prophylaxing the proper verb for prophylaxis; as my spellchecker doesn't like it; oh well perhaps it can be my latest neologism!?)(pps Yes resveratrol is antiviral, used to treat swine pseudorabies, for one, and anecdotal in vitro testing showed it did kill the coronavirus. My theory is that it may work prophylactically, as does quinine, and that the prophylactic dose should be considerably less than the actual therapeutic dose. So the amounts of either that I am talking about here in the few milligram ranges may in fact be enough to be prophylactic for the SARS-CoV-2 in casual societal contacts with potentially infected people. Again, all of this is as of yet, unpublished, but is being studied in several hundred people over the past eight months with no cases of COVID-19 or positive mRNA tests, so far. Again, all this is anecdotal, and should not be relied upon for treatment to make all of the lawyers happy.)(ppps When this whole Pandemic is over, I will go back to all of the people involved and get exact statements as to compliance, etc. possibly for a write-up?)
Consider this cartoon published in Lancet, from 1889 regarding influenza at that time. It depicts a patient being led by a physician, surrounded by politicians. I would like you to note the figure on the bottom left holding a sign saying "quinine!" Wow, things don't change much. Gary Joseph Ordog, MD; January 21, 2021.
