David PS
Member
This interview was posted on YouTube in March 2019. Georgi does not post his interviews on this forum. I could not find this interview here on this forum. So here it is, enjoy!
PART I: Massive thanks to David Bui for the timestamps:
7:21 Vitamin E’s Pro-metabolic Properties
8:13 Difference between today’s mixed Tocopherol supplements & mixed Tocopheral used by Ray Peat in the 60’s and 70’s (Wheat Germ oil extracted)8:32 Wheat Germ Oil Has a Tocohperal Mixture that is high in alpha tocopherol isomer & contains number of “impurities” which have been removed
8:48 Today’s vendors offer soy extracted mixed tocopherols
9:02 Soy extracted mixed tocopherols are high in gamma isomer (less of alpha isomer)
10:05 Benefits from Wheat Germ extracted Vitamin E aside from the mixed tocopherol was due to Polycocinals: Long chain saturated fatty acid alcohols with multiple beneficial effects
11:09 Today’s vendors offering Wheat Germ Oil are 80% fat or higher and have low tocopherol content (thus taking a few 100 units of vitamin E requires taking intake of significant amount of PUFA)
11:36 Tocovit’s development background
14:04 Ray’s thoughts on earlier Tocovit product; More on Tocovit
16:13 No gene/group of genes or a Gene-wide association that has been shown to be responsible for any aspects of health or longevity
16:50 Evidence points to high metabolism/optimal functioning mitochondria as drive of good health and intelligence
19:03 Why might intelligence be linked to energy metabolism
19:47 "Energy availability is lowest common denominator needed for function of all biological systems… Mitochondrial function should explain link between general intelligence, health and aging”
20:10 Decline in Brain ATP has been shown to precipitate decline in cognitive functionto point of person falling into coma,
20:18 Rate of ATP synthesis can predict when a person will fall into a coma
21:35 Chronic stress damages mitochondria; Causes diabetes and cardiovascular disease, & damages intelligence (Stress makes us dumb)
22:18 Progesterone Discussion: Affects on thinking, female and male thinking synergies, post and pre-puberty production differences in the sexes
24:19 Osteoporosis discussion begins
23:34 Women’s Health Initiative Study shows Estrogen’s ineffectiveness against Osteoporosis and other harmful effects (heart attacks, strokes, Alzheimers)
25:11 Declines in Androgens (DHEA) for men and decline in progesterone have primary role in Osteoporosis development
25:26 Increases in Estrogen in both sexes is detrimental to bone health
25:48 Cells in bones are just like any other cell in any other organ (health is dependent on mitochondrial function); Declining mitochondrial function’s effects explained; Declining liver health example
26:45 Mitochondrial function in bone cells: required for regeneration and maintaining balance between osteoblasts and osteoclasts; Declines results in osteoclast shift (resorption/dissolution of bone tissue), Decline of mitochondrial enzyme cytochrome c oxidase drives decrease energy production and osteoclast shift; Nitric oxide is responsible for blocking cytochrome c oxidase
28:13 Nitric Oxide’s multitude of negative effects
28:57 Nitric Oxide’s systemic anti-metabolic role explained: Mediator of stress,emergency vasodilator, & c02 antagonist
30:14 PUFA exacerbates Nitric Oxide production: PUFA’s Nitric Oxide stress cascade and end (Cancer) result explained
31:37 Aspirin’s pro metabolic and anti-fibrotic effects explained
34:50 Discussion on (lack of) evidence of Genes influencing depression begins: The idea of genetic determinism criticized
35:49 No evidence of genetic cause behind function in the serotonin transporter theory: Genetic mutation driving malfunction in serotonin transporter is nonsense/fraud
37:02 "Depression is considered highly to have predominately genetic cause”: Psychiatrists use this as an explanation as to why 60-80% of people do poorly on SSRIs (They claim that it’s “bad” genes)
38:48 All of symptoms of aging can be reproduced by administering extra physiological amount of cortisol: Depression may just be aging of brain
39:19 Cortisol opposing/antagonizing has anti-depressant effects: Most successful anti depressants have been shown to be anti-serotonogertic
40:23 Obesity in middle age is mild form of Cushings: Cortisol’s role in “Dad Bod"
41:09 Things that block cortisol can reverse age related sarcopenia
41:30 Endogenous antagonists of cortisol in body are Progesterone, DHEA, & Pregnenalone; Progesterone has direct activity as antagonist at receptor (Glucocorticoid) level
41:44 Synthesis of Glucocorticoid antagonists (Progesterone, DHEA & Pregnenalone) declines with age while cortisol peaks at puberty and stays at that level for rest of life: An explanation for loss of muscle mass and central obesity with age
43:13 Keto Diet causes liver insulin resistance and raises diabetes risk discussion begins
43:30 Keto Diet shows detrimental changes: Drop in Blood sugar comes at expense of liver fattening, causes liver insulin resistance and eventually probably periphery tissue resistance (results in diabetes type 2)
46:31 Synthesis of glucose at any cost suggests its’ importance
48:07 Dieting is Deleterious Discussion begins: How Low Carb & Exhaustive Exercise are conducive to cortisol synthesis and decrease cortisol deactivation enzymes (chronic stress); Calorie restriction and calorie monitoring increases cortisol in humans
48:26 Low carb diet enhances cortisol regeneration/synthesis through up regulation of enzyme 11 beta HSD type 1 (active cortisol) and decreases cortisol deactivation enzyme (11 beta HSD type 2)
48:50 Enzymes 11Beta HSD1 and 11Beta HSD2 explained; Active cortisol and Inactive cortisone explained
50:18 Exhaustive exercise ruins metabolism and causes sub clinical Cushings syndrome
51:04 Calorie restriction increased total output of cortisol and monitoring calories increase perceived psychological stress
53:23 Obesity rates are increasing discussion begins: Debunking the eat less/move more mantra; Most increases in obesity rates are due to rural populations (environmental factors)
56:37 EMF increases Nitric Oxide; EMF affects tissues by slowing metabolism
58:18 Danny’s Airport Story
59:14 Endotoxin may cause depression & anhedonia discussion begins
59:30 Endotoxin and effects explained; SIBO in Hypothyroid people
1:00:30 Endotoxin is independent activator of stress systems
1:01:04 Cortisol has two primary roles: Maintain elevating blood sugar in stress but as anti-inflammatory steroid
1:01:41 Endotoxin is cardinal endogenous driver of inflammation: Can be produced at any time not just as bacterial metabolite byproduct but also through mechanical stimulation (e.g.; long distance running)
1:02:29 Long distance runners & diarhea
1:03:08 Serotonin is primary cause of diarrhea
1:03:18 Glucose is regulator of stress systems discussion begins: Low Glucose and Aging/Inflammation explained; Hypoglycemia (not dietary carbohydrate) is result of stress response
1:04:38 Hyper lipidemia (Elevated Free Fatty Acids in blood) always present in those with hyperglycemia
1:05:09 Glucose has no inflammatory mediator pathway & does not trigger nitric oxide or serotonin synthesis
1:05:38 Glucose has anti-stress effect on hypothalamus by lowering synthesis and release of CRH; The mouth can detect presence of glucose
1:06:24 CRH: Initiator of stress cascade, inflammatory peptide and potential primary cause of multiple sclerosis
1:06:37 Pregnenalone & its metabolites (Progesterone, Allopregnenalone) are CRH antagonists
1:07:13 Fructose turning to fat myth debunked: half a kilo of sugar must be eaten to be turned into fat; Fructose primarily converts to glycogen
1:07:43 No current paper demonstrating the overfeeding of sugar in the presence of low fat is causative of obesity in the literature
1:08:15 Cola & Rats study: Drinking Coke Freely Quadruples calorie intake and does not result in weight gain
1:09:28 Heath comparison of High sugar+High fat and High fat+Low carb
1:10:31 Glucose tolerance test study in low carb carnivore dieters
1:11:26 Sugar & Hedonism Link: Anhedonia/depression removes sugar preference and decreases appetite; Depression has state of insulin resistance
1:12:53 Blocking Endotoxin may cure Diabetes Type 1 Discussion: Insulin synthesis in Beta cells can be recovered by blocking endotoxin sensing receptor (TLR4)
1:15:15 Clinical human trials with Niacinimide have shown that children can reverse early stages of diabetes type
11:15:37 Ray Peat’s Thoughts on diabetes cause: Elevated Free Fatty Acids or Excessive Nitric Oxide Production; Diabetes is metabolic dysfunction driven by diet &/or stress
1:17:09 Selective serotonin antagonist is powerful anti depressant discussion: A major knock on Serotonin’s “happy” hormone status
1:17:49 Psychotic diseases likely due to serotonin excess; Psychotic treatment drugs are likely anti-serotonergic
1:18:40 Schizophrenia drug’s mysterious wikipedia update: Haloperidol’s affinity for receptors and major serotonin antagonist revealed
1:19:15 Georgi’s Hypothesis: Based on combination of serotonin opposing drugs (Haloperidol & Pimavancerin), there is serious evidence for serotonin causing depression and schizophrenia
1:20:05 Aspirin Decreases Risk of Bleeding in Brain Discussion: Big Pharma’s Aspirin Lies Invalidated
1:21:40 Aspirin decerases risk of dying from bleeding events no matter the cause; GI Tract Bleeding is not as harmful as it depletes iron stores
Edit
PART II: Massive thanks to David Bui for the timestamps.
1:23:43 Pension system is supported by cancer: Aspirin’s cancer preventive effects threaten cancer treatment income
1:26:21 Cancer is a metabolic disease treatable by diet Discussion begins:
1:26:43 Chronic Metabolic Acidosis is all that is needed for cancer or metastasis (Study)
1:26:52 Cancer cell is alkaline inside and acidic outside (Study)
1:27:20 Baking Soda stops tumor and removes metastasis
1:28:28 Metformin Rebuked: A Direct Cancer promoter1
:31:57 No gene/group of genes or environmental-genetic interaction can explain cancer; Current cancer treatments simply mask the problem
1:33:04 Cachexia: Carbohydrate restriction with Cancer will break down body for glucose
1:37:24 Harvard Study: Neuro Glialblastoma can be cured
1:37:46 Patreon Questions begin
1:37:55 Q: How to Increase Oral Tolerance and effective ways to decrease food sensitivities?-Food Sensitivities come from GI Dysfunction- Allergies begin in intestine (Serotonin likely to be cause) -Ray thinks Antibiotics are best for allergies-Some Saturated fats have anti-serotonin and anti-allergic benefits- Increased ingestion of complete proteins low in tryptophan lower serotonin & tryptophan stores-Gelatin decreases intestinal sensitivity-Blood Sugar & Allergy Link-Catatoxic steroids (Pregnenalone, Progesterone, DHEA, Testosterone) decrease allergic reactions
1:43:01 Q: What do you think of non-absorbable antibiotics such as Rifaximin to manage IBS and Mast cell activation problems? -Stomach Acid production can resolve SIBO but does not clear up endotoxin production (Microbiome needs to be cleared)- Ways to increase stomach acid production
1:45:32 Q: Are there any substances that can deliver drugs into bones? -Suggestive method to achieve this-Adamantane: A Highly Lipophilic chemical used in pharmaceuticals
1:47:31 Q: Is topical application supplementation of aspirin as Solban more potent than oral and requires less dose? What is simple protocol to improve liver health?-Solban product clarification-Aspirin and Niacinmide should be taken orally-Liver Health Protocol & Tips -Liver Damages is due to per oxidation of unsaturated fats; -Anorexia & Liver Health-High Ammonia induced Comas only happen in late stages of liver disease-Protein and Cirrhosis reversal
1:53:17 Q: Alternatives to Oyster and Beef Liver?-Nutrients in other organs explained
1:56:57 Q: Best supplements to boost energy before a Rugby game (Intense Exercise)-Caffeine should be taken with Sugar to avoid stress response-Lowering serotonin has anti fatigue effect; -Blocking Acidosis (Lactic acid) response is beneficial; -Baking soda, Beta-alanine & Methelyne Blue are all effective acidosis blocking performance enhancers; -Non-sedating serotonin antagonist would be ideal-Cyprohepdatine has brief sedating effect but can increase performance by 20%
2:00:34 Q How to increase bread growth, bone density and strength with elevating T3 and DHT: -T3 & Topical Androgens and Androgen precursors are likely to increase beard density
2:02:10 Q Is there a chance to restart testosterone... (Confusing question): -Danny’s poor thoughts on testosterone replacement therapy; -Most harm from TRT stems from esters used in them; -Raw testosterone dissolved in tocopherol is powerful at low doses and is safer-Testosterone in low doses by itself is potent aromatase (estrogen) inhibitor-Testosterone metabolism is usually downstream but goes upstream with over saturation and with high ester dosages-Logorrhea: Estrogen induced autoimmuncondition (People that talk incoherently)
2:09:16 Q: What can be done to rememdy histamine intoloerance that is causing systemic and circulatory problems:-Histamine intolerance likely due to digestion problems-Aspirin taken with glycine can eliminate allergic reactions-Aspirin with baking soda is another alternative
2:11:10 Q: Thoughts on feeling worse in summer, heat intolerance, heat exhaustion, headache from sun, worse digestion and so on:-Heat & Cold intolerance is likely sign of hypothyroidism-Salt & Orange Juice is good remedy-Vitamin D is a crucial “broken" steroid: how it makes steroid receptors work well with respective steroids
2:15:40 Q: Is white spelt bread better than whole spelt bread:Easily digested is best (undigested food results in endotoxin overload)
2:17:51 Q: Reasons for not having enough saliva flow which leads to inefficient mineralization of teeth at night?-Dry mouth is due to adrenaline excess;-Salt, gum & beewax tips-Sjögren's syndrome: Caused by androgen deficiency
2:20:51 Q: Does 200 to 500 micrograms of potassium iodide reasonable for salivation issues?-Microgram range is safe-Iodide deficiency is low
2:21:34 Q: Can you talk about experience with food quality depending on where you are? -Most commercial food in western food is not only highly processed but is almost “supplement-like” with additives like silica, cellulose derivatives, carrageenan and gums etc;
2:25:44 Q: What is cause of gastritis and is there any way it reverse it?-Gastritus and GERD is inflammatory disease-Proton pump inhibitors are ineffective-Histamine H2 antagonist Famotidine is most successful drug to date for Gastritus-Famotidine benefits-Delerium is driven by serotonin-Cyproheptadine is likely to work as well-Gelatin is also effective for Gastirtus
2:29:22 Q: Thoughts on seven keto-DHEA and its use for fat loss?-Seven Keto-DHEA is not recommended: Does not antagonize cortisol long term and lowers testosterone, lowers progesterone and pregnenalone synthesis
2:32:10 Q: Why might progesterone cause bile/gut issue?-Inability to meet bile acid need or low cholesterol is likely issue-Low cholesterol affects digestion
2:35:10 Q: Thoughts on research published by GM & Network suggesting sugar content in both soda and fruit juice contribute to shortened life spans?-Intervention studies with increased carbohydrate show opposite effect;-Stress is more likely to be the culprit—not sugar
2:37:39 Q:Should Calcium to phosphate ratio be monitored at every meal is a longer period acceptable to monitor?-Limiting muscle meats and increasing dairy is sufficient to shift the balance favourably-Sugar (particularly fructose) lowers phosphate-Parathyroid and Prolactin are sensitive to phosphate
2:40:10 Q: Is morning wood a sign of good health?-Morning wood is generally sign of high testosterone-Uncontrollable libido can also be caused by elevated estrogen-DHEA is ideal in upper 25% of normal range (more important than testosterone)-Quality of orgasm and ejaculation is indicative of good testosterone-POS: Post Orgasmic Syndrome (malaise after ejaculation) -Recovery after orgasm is good indicator of systemic health
2:43:24 Q: Ways to lower cholesterol safely?-Increase metabolism-30-50mg of pregnenalone (or other steroids high in cascade) can drop cholesterol significantly-2 quarts of milk lower cholesterol-Increase bile acid synthesis consumes cholesterol-Taurine increases bile acid synthesis
2:46:04 Q: Is blue light effective after acne causing bacteria?-Blue light is harmful (synthesizes nitric oxide and serotonin)
2:47:48 Q: Talk about Histamine intolerance?-Due to SIBO and insufficient stomach acid production-Other tips for intolerance
2:50:14 Q: Can Bruxism be fixed by lowering serotonin?-Yes it can be solved: it is sign of hypothyroidism and elevated serotonin-Bruxism has nightmares and is common in PTSD (High adrenaline, cortisol and serotonin)-Cyprohepdatine has been used to treat it
2:51:23 Q: What can be used besides antibiotics to lower bacteria in intestine?-Charcoal can be used although Ray Peat is not proponent of it;-Indigestible fiber can be used-Photodynamic therapy has promising anti-fungal and anti-biotic effect-Aspirin & Niacinimide have anti-bacterial effect -Spore bionics and bacteria phages are over counter options
2:57:56 Georgi’s next products: A New Serotonin antagonist that increases GABBA levels in brain
2:58:12 Alternative to amino acid P chlorophyll Alanine aka Fenclonine: inhibitor of serotonin synthesis
2:59:06 Immune system potentiator product (Russian drug)
3:01:34 Thoughts on covering social issues next podcast: Shifting away from false dogmas
PART I: Massive thanks to David Bui for the timestamps:
7:21 Vitamin E’s Pro-metabolic Properties
8:13 Difference between today’s mixed Tocopherol supplements & mixed Tocopheral used by Ray Peat in the 60’s and 70’s (Wheat Germ oil extracted)8:32 Wheat Germ Oil Has a Tocohperal Mixture that is high in alpha tocopherol isomer & contains number of “impurities” which have been removed
8:48 Today’s vendors offer soy extracted mixed tocopherols
9:02 Soy extracted mixed tocopherols are high in gamma isomer (less of alpha isomer)
10:05 Benefits from Wheat Germ extracted Vitamin E aside from the mixed tocopherol was due to Polycocinals: Long chain saturated fatty acid alcohols with multiple beneficial effects
11:09 Today’s vendors offering Wheat Germ Oil are 80% fat or higher and have low tocopherol content (thus taking a few 100 units of vitamin E requires taking intake of significant amount of PUFA)
11:36 Tocovit’s development background
14:04 Ray’s thoughts on earlier Tocovit product; More on Tocovit
16:13 No gene/group of genes or a Gene-wide association that has been shown to be responsible for any aspects of health or longevity
16:50 Evidence points to high metabolism/optimal functioning mitochondria as drive of good health and intelligence
19:03 Why might intelligence be linked to energy metabolism
19:47 "Energy availability is lowest common denominator needed for function of all biological systems… Mitochondrial function should explain link between general intelligence, health and aging”
20:10 Decline in Brain ATP has been shown to precipitate decline in cognitive functionto point of person falling into coma,
20:18 Rate of ATP synthesis can predict when a person will fall into a coma
21:35 Chronic stress damages mitochondria; Causes diabetes and cardiovascular disease, & damages intelligence (Stress makes us dumb)
22:18 Progesterone Discussion: Affects on thinking, female and male thinking synergies, post and pre-puberty production differences in the sexes
24:19 Osteoporosis discussion begins
23:34 Women’s Health Initiative Study shows Estrogen’s ineffectiveness against Osteoporosis and other harmful effects (heart attacks, strokes, Alzheimers)
25:11 Declines in Androgens (DHEA) for men and decline in progesterone have primary role in Osteoporosis development
25:26 Increases in Estrogen in both sexes is detrimental to bone health
25:48 Cells in bones are just like any other cell in any other organ (health is dependent on mitochondrial function); Declining mitochondrial function’s effects explained; Declining liver health example
26:45 Mitochondrial function in bone cells: required for regeneration and maintaining balance between osteoblasts and osteoclasts; Declines results in osteoclast shift (resorption/dissolution of bone tissue), Decline of mitochondrial enzyme cytochrome c oxidase drives decrease energy production and osteoclast shift; Nitric oxide is responsible for blocking cytochrome c oxidase
28:13 Nitric Oxide’s multitude of negative effects
28:57 Nitric Oxide’s systemic anti-metabolic role explained: Mediator of stress,emergency vasodilator, & c02 antagonist
30:14 PUFA exacerbates Nitric Oxide production: PUFA’s Nitric Oxide stress cascade and end (Cancer) result explained
31:37 Aspirin’s pro metabolic and anti-fibrotic effects explained
34:50 Discussion on (lack of) evidence of Genes influencing depression begins: The idea of genetic determinism criticized
35:49 No evidence of genetic cause behind function in the serotonin transporter theory: Genetic mutation driving malfunction in serotonin transporter is nonsense/fraud
37:02 "Depression is considered highly to have predominately genetic cause”: Psychiatrists use this as an explanation as to why 60-80% of people do poorly on SSRIs (They claim that it’s “bad” genes)
38:48 All of symptoms of aging can be reproduced by administering extra physiological amount of cortisol: Depression may just be aging of brain
39:19 Cortisol opposing/antagonizing has anti-depressant effects: Most successful anti depressants have been shown to be anti-serotonogertic
40:23 Obesity in middle age is mild form of Cushings: Cortisol’s role in “Dad Bod"
41:09 Things that block cortisol can reverse age related sarcopenia
41:30 Endogenous antagonists of cortisol in body are Progesterone, DHEA, & Pregnenalone; Progesterone has direct activity as antagonist at receptor (Glucocorticoid) level
41:44 Synthesis of Glucocorticoid antagonists (Progesterone, DHEA & Pregnenalone) declines with age while cortisol peaks at puberty and stays at that level for rest of life: An explanation for loss of muscle mass and central obesity with age
43:13 Keto Diet causes liver insulin resistance and raises diabetes risk discussion begins
43:30 Keto Diet shows detrimental changes: Drop in Blood sugar comes at expense of liver fattening, causes liver insulin resistance and eventually probably periphery tissue resistance (results in diabetes type 2)
46:31 Synthesis of glucose at any cost suggests its’ importance
48:07 Dieting is Deleterious Discussion begins: How Low Carb & Exhaustive Exercise are conducive to cortisol synthesis and decrease cortisol deactivation enzymes (chronic stress); Calorie restriction and calorie monitoring increases cortisol in humans
48:26 Low carb diet enhances cortisol regeneration/synthesis through up regulation of enzyme 11 beta HSD type 1 (active cortisol) and decreases cortisol deactivation enzyme (11 beta HSD type 2)
48:50 Enzymes 11Beta HSD1 and 11Beta HSD2 explained; Active cortisol and Inactive cortisone explained
50:18 Exhaustive exercise ruins metabolism and causes sub clinical Cushings syndrome
51:04 Calorie restriction increased total output of cortisol and monitoring calories increase perceived psychological stress
53:23 Obesity rates are increasing discussion begins: Debunking the eat less/move more mantra; Most increases in obesity rates are due to rural populations (environmental factors)
56:37 EMF increases Nitric Oxide; EMF affects tissues by slowing metabolism
58:18 Danny’s Airport Story
59:14 Endotoxin may cause depression & anhedonia discussion begins
59:30 Endotoxin and effects explained; SIBO in Hypothyroid people
1:00:30 Endotoxin is independent activator of stress systems
1:01:04 Cortisol has two primary roles: Maintain elevating blood sugar in stress but as anti-inflammatory steroid
1:01:41 Endotoxin is cardinal endogenous driver of inflammation: Can be produced at any time not just as bacterial metabolite byproduct but also through mechanical stimulation (e.g.; long distance running)
1:02:29 Long distance runners & diarhea
1:03:08 Serotonin is primary cause of diarrhea
1:03:18 Glucose is regulator of stress systems discussion begins: Low Glucose and Aging/Inflammation explained; Hypoglycemia (not dietary carbohydrate) is result of stress response
1:04:38 Hyper lipidemia (Elevated Free Fatty Acids in blood) always present in those with hyperglycemia
1:05:09 Glucose has no inflammatory mediator pathway & does not trigger nitric oxide or serotonin synthesis
1:05:38 Glucose has anti-stress effect on hypothalamus by lowering synthesis and release of CRH; The mouth can detect presence of glucose
1:06:24 CRH: Initiator of stress cascade, inflammatory peptide and potential primary cause of multiple sclerosis
1:06:37 Pregnenalone & its metabolites (Progesterone, Allopregnenalone) are CRH antagonists
1:07:13 Fructose turning to fat myth debunked: half a kilo of sugar must be eaten to be turned into fat; Fructose primarily converts to glycogen
1:07:43 No current paper demonstrating the overfeeding of sugar in the presence of low fat is causative of obesity in the literature
1:08:15 Cola & Rats study: Drinking Coke Freely Quadruples calorie intake and does not result in weight gain
1:09:28 Heath comparison of High sugar+High fat and High fat+Low carb
1:10:31 Glucose tolerance test study in low carb carnivore dieters
1:11:26 Sugar & Hedonism Link: Anhedonia/depression removes sugar preference and decreases appetite; Depression has state of insulin resistance
1:12:53 Blocking Endotoxin may cure Diabetes Type 1 Discussion: Insulin synthesis in Beta cells can be recovered by blocking endotoxin sensing receptor (TLR4)
1:15:15 Clinical human trials with Niacinimide have shown that children can reverse early stages of diabetes type
11:15:37 Ray Peat’s Thoughts on diabetes cause: Elevated Free Fatty Acids or Excessive Nitric Oxide Production; Diabetes is metabolic dysfunction driven by diet &/or stress
1:17:09 Selective serotonin antagonist is powerful anti depressant discussion: A major knock on Serotonin’s “happy” hormone status
1:17:49 Psychotic diseases likely due to serotonin excess; Psychotic treatment drugs are likely anti-serotonergic
1:18:40 Schizophrenia drug’s mysterious wikipedia update: Haloperidol’s affinity for receptors and major serotonin antagonist revealed
1:19:15 Georgi’s Hypothesis: Based on combination of serotonin opposing drugs (Haloperidol & Pimavancerin), there is serious evidence for serotonin causing depression and schizophrenia
1:20:05 Aspirin Decreases Risk of Bleeding in Brain Discussion: Big Pharma’s Aspirin Lies Invalidated
1:21:40 Aspirin decerases risk of dying from bleeding events no matter the cause; GI Tract Bleeding is not as harmful as it depletes iron stores
Edit
PART II: Massive thanks to David Bui for the timestamps.
1:23:43 Pension system is supported by cancer: Aspirin’s cancer preventive effects threaten cancer treatment income
1:26:21 Cancer is a metabolic disease treatable by diet Discussion begins:
1:26:43 Chronic Metabolic Acidosis is all that is needed for cancer or metastasis (Study)
1:26:52 Cancer cell is alkaline inside and acidic outside (Study)
1:27:20 Baking Soda stops tumor and removes metastasis
1:28:28 Metformin Rebuked: A Direct Cancer promoter1
:31:57 No gene/group of genes or environmental-genetic interaction can explain cancer; Current cancer treatments simply mask the problem
1:33:04 Cachexia: Carbohydrate restriction with Cancer will break down body for glucose
1:37:24 Harvard Study: Neuro Glialblastoma can be cured
1:37:46 Patreon Questions begin
1:37:55 Q: How to Increase Oral Tolerance and effective ways to decrease food sensitivities?-Food Sensitivities come from GI Dysfunction- Allergies begin in intestine (Serotonin likely to be cause) -Ray thinks Antibiotics are best for allergies-Some Saturated fats have anti-serotonin and anti-allergic benefits- Increased ingestion of complete proteins low in tryptophan lower serotonin & tryptophan stores-Gelatin decreases intestinal sensitivity-Blood Sugar & Allergy Link-Catatoxic steroids (Pregnenalone, Progesterone, DHEA, Testosterone) decrease allergic reactions
1:43:01 Q: What do you think of non-absorbable antibiotics such as Rifaximin to manage IBS and Mast cell activation problems? -Stomach Acid production can resolve SIBO but does not clear up endotoxin production (Microbiome needs to be cleared)- Ways to increase stomach acid production
1:45:32 Q: Are there any substances that can deliver drugs into bones? -Suggestive method to achieve this-Adamantane: A Highly Lipophilic chemical used in pharmaceuticals
1:47:31 Q: Is topical application supplementation of aspirin as Solban more potent than oral and requires less dose? What is simple protocol to improve liver health?-Solban product clarification-Aspirin and Niacinmide should be taken orally-Liver Health Protocol & Tips -Liver Damages is due to per oxidation of unsaturated fats; -Anorexia & Liver Health-High Ammonia induced Comas only happen in late stages of liver disease-Protein and Cirrhosis reversal
1:53:17 Q: Alternatives to Oyster and Beef Liver?-Nutrients in other organs explained
1:56:57 Q: Best supplements to boost energy before a Rugby game (Intense Exercise)-Caffeine should be taken with Sugar to avoid stress response-Lowering serotonin has anti fatigue effect; -Blocking Acidosis (Lactic acid) response is beneficial; -Baking soda, Beta-alanine & Methelyne Blue are all effective acidosis blocking performance enhancers; -Non-sedating serotonin antagonist would be ideal-Cyprohepdatine has brief sedating effect but can increase performance by 20%
2:00:34 Q How to increase bread growth, bone density and strength with elevating T3 and DHT: -T3 & Topical Androgens and Androgen precursors are likely to increase beard density
2:02:10 Q Is there a chance to restart testosterone... (Confusing question): -Danny’s poor thoughts on testosterone replacement therapy; -Most harm from TRT stems from esters used in them; -Raw testosterone dissolved in tocopherol is powerful at low doses and is safer-Testosterone in low doses by itself is potent aromatase (estrogen) inhibitor-Testosterone metabolism is usually downstream but goes upstream with over saturation and with high ester dosages-Logorrhea: Estrogen induced autoimmuncondition (People that talk incoherently)
2:09:16 Q: What can be done to rememdy histamine intoloerance that is causing systemic and circulatory problems:-Histamine intolerance likely due to digestion problems-Aspirin taken with glycine can eliminate allergic reactions-Aspirin with baking soda is another alternative
2:11:10 Q: Thoughts on feeling worse in summer, heat intolerance, heat exhaustion, headache from sun, worse digestion and so on:-Heat & Cold intolerance is likely sign of hypothyroidism-Salt & Orange Juice is good remedy-Vitamin D is a crucial “broken" steroid: how it makes steroid receptors work well with respective steroids
2:15:40 Q: Is white spelt bread better than whole spelt bread:Easily digested is best (undigested food results in endotoxin overload)
2:17:51 Q: Reasons for not having enough saliva flow which leads to inefficient mineralization of teeth at night?-Dry mouth is due to adrenaline excess;-Salt, gum & beewax tips-Sjögren's syndrome: Caused by androgen deficiency
2:20:51 Q: Does 200 to 500 micrograms of potassium iodide reasonable for salivation issues?-Microgram range is safe-Iodide deficiency is low
2:21:34 Q: Can you talk about experience with food quality depending on where you are? -Most commercial food in western food is not only highly processed but is almost “supplement-like” with additives like silica, cellulose derivatives, carrageenan and gums etc;
2:25:44 Q: What is cause of gastritis and is there any way it reverse it?-Gastritus and GERD is inflammatory disease-Proton pump inhibitors are ineffective-Histamine H2 antagonist Famotidine is most successful drug to date for Gastritus-Famotidine benefits-Delerium is driven by serotonin-Cyproheptadine is likely to work as well-Gelatin is also effective for Gastirtus
2:29:22 Q: Thoughts on seven keto-DHEA and its use for fat loss?-Seven Keto-DHEA is not recommended: Does not antagonize cortisol long term and lowers testosterone, lowers progesterone and pregnenalone synthesis
2:32:10 Q: Why might progesterone cause bile/gut issue?-Inability to meet bile acid need or low cholesterol is likely issue-Low cholesterol affects digestion
2:35:10 Q: Thoughts on research published by GM & Network suggesting sugar content in both soda and fruit juice contribute to shortened life spans?-Intervention studies with increased carbohydrate show opposite effect;-Stress is more likely to be the culprit—not sugar
2:37:39 Q:Should Calcium to phosphate ratio be monitored at every meal is a longer period acceptable to monitor?-Limiting muscle meats and increasing dairy is sufficient to shift the balance favourably-Sugar (particularly fructose) lowers phosphate-Parathyroid and Prolactin are sensitive to phosphate
2:40:10 Q: Is morning wood a sign of good health?-Morning wood is generally sign of high testosterone-Uncontrollable libido can also be caused by elevated estrogen-DHEA is ideal in upper 25% of normal range (more important than testosterone)-Quality of orgasm and ejaculation is indicative of good testosterone-POS: Post Orgasmic Syndrome (malaise after ejaculation) -Recovery after orgasm is good indicator of systemic health
2:43:24 Q: Ways to lower cholesterol safely?-Increase metabolism-30-50mg of pregnenalone (or other steroids high in cascade) can drop cholesterol significantly-2 quarts of milk lower cholesterol-Increase bile acid synthesis consumes cholesterol-Taurine increases bile acid synthesis
2:46:04 Q: Is blue light effective after acne causing bacteria?-Blue light is harmful (synthesizes nitric oxide and serotonin)
2:47:48 Q: Talk about Histamine intolerance?-Due to SIBO and insufficient stomach acid production-Other tips for intolerance
2:50:14 Q: Can Bruxism be fixed by lowering serotonin?-Yes it can be solved: it is sign of hypothyroidism and elevated serotonin-Bruxism has nightmares and is common in PTSD (High adrenaline, cortisol and serotonin)-Cyprohepdatine has been used to treat it
2:51:23 Q: What can be used besides antibiotics to lower bacteria in intestine?-Charcoal can be used although Ray Peat is not proponent of it;-Indigestible fiber can be used-Photodynamic therapy has promising anti-fungal and anti-biotic effect-Aspirin & Niacinimide have anti-bacterial effect -Spore bionics and bacteria phages are over counter options
2:57:56 Georgi’s next products: A New Serotonin antagonist that increases GABBA levels in brain
2:58:12 Alternative to amino acid P chlorophyll Alanine aka Fenclonine: inhibitor of serotonin synthesis
2:59:06 Immune system potentiator product (Russian drug)
3:01:34 Thoughts on covering social issues next podcast: Shifting away from false dogmas
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