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The role of immunoglobulin E and mast cells in hypertension - PubMed
Our findings reveal that IgE contributes to the pathogenesis of hypertension, at least partially through activating the IgE-FcεR1 signalling in MCs. Thus, IgE may represent a new therapeutic target for IgE-mediated hypertension.
pubmed.ncbi.nlm.nih.gov
Mast cells and metabolic syndrome: Hypertension, obesity and atherosclerosis - Mast Attack
Metabolic syndrome is defined as impaired glucose tolerance (IGT) or type 2 diabetes and/or insulin resistance with two or more of the following findings: 1. Abdominal obesity, defined as a BMI ≥30; and/or waist to hip ratio >0.90 in men and >0.85 in women 2. Baseline blood pressure...
www.mastattack.org
Mast cells and εPKC: A role in cardiac remodeling in hypertension-induced heart failure
Heart failure (HF) is a chronic syndrome in which pathological cardiac remodeling is an integral part of the disease and mast cell (MC) degranulation-derived mediators have been suggested to play a role in its progression. Protein kinase C (PKC) signaling ...
www.ncbi.nlm.nih.gov
Increased mast cell number in human hypertensive nephropathy - PubMed
Mast cells have recently been related to nonallergic chronic organ damage and fibrosis. In the present study, we analyzed mast cell number, localization, and maturation in the kidney of a relatively unique group of middle-aged accident victims with primary essential hypertension and in...
pubmed.ncbi.nlm.nih.gov
From my notes - I don't have sources
Dr. Ray Peat on Histamine
And one of the things that turns on the production of more mast cells or the secretion or leakage of histamine from the mast cells is prostaglandins produced from the polyunsaturated fatty acids, especially prostaglandin E 2. Besides making the prostaglandins in themselves they cause changes in cells that disrupt their functions. In fact every function of the cell can be disrupted by too much of the polyunsaturated fats. And one of the worst things they do is to interrupt oxidative metabolism and the energy deficit I think is ultimately the thing that leads to really serious allergy problems.
It turns out that the same things that cure or help to escape from learned helplessness also helped to stop or reduce the inflammatory reaction and reduce histamine production. And T3, the active form of thyroid hormone was one of the early things that discovered would cure learned helplessness and it does several things that prevent overproduction of histamine. It's been known for anti- inflammatory for a long time but one of its mechanisms is to stabilize mast cells so they don't secrete serotonin, histamine and other inflammatory things.
Calcium and vitamin D are two of the things that are very strongly anti-allergic. Magnesium is the most famous because of magnesium deficiency, they found caused terrific range of inflammatory diseases in animals and they would cure skin diseases, heart disease, nerve disease, liver disease and so on just by correcting a magnesium deficiency. With vitamin D and calcium working with magnesium are very important so that some people cure their allergies just by supplementing vitamin D or vitamin K which is the other major calcium regulating vitamin.
Except sometimes they can break the pattern like vitamin E has antihistamine effect. For example, it prevents the formation of prostaglandins, and as a consequence will prevent the degranulation of mast cells, and so it can prevent the shift to the IgE antibody and the whole thing. Q: You’re saying the histamine is creating a vicious cycle so we do want to break that cycle? Dr. Ray Peat: Yes, breaking the cycle. Even various antihistamines and other drugs can help to break that cycle. Q: And you said before that like nitric acid is also kind of a vicious loop going between histamine and nitric acid which you kind of created Andrew Murray: I think you mean nitric oxide I mean? Dr. Ray Peat: Yes, histamine turns on the production of nitric oxide and nitric oxide signals a bunch of other inflammatory processes, but the worst thing is that it interferes with oxygen energy production. Q: Okay. So the mucus falling though is probably a good thing but it may be a part of that vicious cycle, I guess, that we would like to stop? Dr. Ray Peat: Yes, the mucus itself is fine. It's helpful but you wouldn't have to produce it if you would then have the inflammation.
So two quick questions I have is, I've been experiencing terrible allergies for the past month and noticed that my symptoms dramatically flare up when I go to sleep like it’s very difficult for me to fall asleep. And do you know why that happens? That's the first question. The second question is what do you recommend I do to alleviate those Q: symptoms? Andrew Murray: Yes. Dr. Ray Peat: Yes, I think it's because that's when the parasympathetic system kicks in and it lowers your blood sugar and that combination turns on the histamine release and inflammation. And I experimented – I had that pattern of sleep onset asthma and I found that Jimson weed or atropine, the belladonna type chemical breaks the muscarinic part of the parasympathetic reaction. And I found that that would keep me from going in that very low blood sugar state. But the trouble is relying on the anti-cholinergic is that it tends to dry your mouth and that gives you tooth decay from the absence of saliva flow during the night. So it is an emergency treatment but the real thing I think is to adjust your thyroid and progesterone. Progesterone has broad variety of antihistamine effects. Estrogen turns on both the multiplication of mast cells and their tendency to release histamine and serotonin. And so getting your thyroid to a good level will reduce your estrogen and increase your progesterone and shift the balance in histamine production. Aspirin is another antihistamine that works indirectly by reducing prostaglandin production and nitric oxide production and such. Andrew Murray: You could easily take the three – say 325 milligram tablets in the day. I know some people who take considerably more than that and in conjunction with vitamin K one drop per 325 milligram tablet if it is one ml per drop vitamin K 2 solution is adequate to offset any potential hemorrhagic or
hemodynamic effects of blood thinning that some individual may get, it’s relatively rare but so 900 milligrams a day, that would be a fairly – for people that are suffering with allergies that would also be quite a good approach to self treatment. Dr. Ray Peat: I think so. And sometimes just taking 300 to 500 milligrams before bedtime so they get time to get absorbed before you actually falling asleep.”
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