Mast Cells And Serotonin

mas

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Current diagnostic dogma of "Fibromyalgia" is that the patient has nothing more than abnormal pain processing, and that there are no other physiological abnormalities whatsoever. Some diagnosticians claim it is nothing but depression. Many people with any number of "diagnosed" diseases get FM tacked on and get prescriptions for very expensive drugs such as Lyrica and Cymbalta which have many bad side effects.

Dr. Ignacio Blanco of Spain and associates found in their research studies that Fibromyalgia patients have mast cell proliferation in their skin and normals have much lower levels. Mast cells proliferate in bone marrow and are found all over the body- nerves,heart, brain, gut, connective tissue, etc..

http://www.ncbi.nlm.nih.gov/pubmed/20428906

Dr. Blanco was forced to retire by the Spanish government. Big Pharma perhaps?

http://www.alfa1doc.blogspot.com

Ray Peat's approach goes right to the core of the problem suggesting cyproheptadine, benadryl and aspirin. I was on Loratadine and Zantac as H1 & H2 blockers, but RP thinks that these are too hard on the liver.

People don't have to be covered in hives to have mast cell which degranulates and gives off serotonin and histamine (estrogen goes with this and exacerbates the serotonin release according to RP). There are other symptoms such as flushing, rapid heartbeat, blood vessel spasms, faintness… (huge list of symptoms found in all "autoimmune disease.")

I try to keep learning and adjusting in hopes that my efforts will pay off with even good health.
 

Suikerbuik

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Ray Peat's approach goes right to the core of the problem suggesting cyproheptadine, benadryl and aspirin.

I'd say to the core of your symptoms.

Because, what causes your mast cells to become active and secrete? Why is there initial inflammation in a particular area? Why do you possible react to food particles? Why is your gut possible more permeable?

I say possible because I don't know your situation, anyway I don't think I'm wrong.

I try to keep learning and adjusting in hopes that my efforts will pay off with even good health.
All the best :)! learning will certainly pay off, if not with great health then with acceptance of the immensely complex situation we're dealing with and understanding of our problems.
 

Blossom

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I thought it could happen to any of us to one extent or another when the metabolism is impaired. I know that's oversimplifying things a bit but that is how I view it from reading Peat. Just as one problematic aspect of being human that we should be aware of in order to minimize the negative consequences. I love this topic! It's so intricately involved in what we are trying to correct and repair with a Peat inspired approach.
 
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mas

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Thanks Blossom.

I have tried the Loratidine and Zantac as H1 & H2 that Dr. Afrin,Hematologist and a mast cell activation specialist recommends, but I cut back on that due to the liver concerns that RP stated.

I will try the Periactin (UK and Canadian drugs here and I was looking for cyproheptadine and just the other day I read a post here and it was referred to as Periactin ) I can get Periactin at the drugstore here! I am going to try this this weekend and have high hopes as my past history of IBS, flushing, bloating really aren't resolved enough using the H1 & H2. I do have serotonin issues

Hope it works as well for me as it did for you.
 

Blossom

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Please keep us posted. Some forum members start as low as 1/8 tablet at bedtime and gradually increase it as tolerated. I'm so excited for you!
 
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mas

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Thanks -I look forward to trying this too.

I have not started the NDT yet, as I feel that I need to work more on reducing the estrogen/serotonin. I am still taking my Progest-E and need to reorder soon. Slowly but surely moving along.
 

Blossom

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mas said:
Thanks -I look forward to trying this too.

I have not started the NDT yet, as I feel that I need to work more on reducing the estrogen/serotonin. I am still taking my Progest-E and need to reorder soon. Slowly but surely moving along.
Sounds like you have come up with a good plan mas! I recently decreased my Progest-e simply because I was trying to make my bottle last until my order arrived. My approach has been changing but the encouraging part is that things continue to improve. I can't ask for more that! It does amaze me everyday that I continue to see improvement. It is so contrary to what I was indoctrinated to believe by 'medicine'. I love hearing others stories of healing because if further shatters the myths that have been forced upon us by a society that bases medical 'evidence' on fraud and lies. Ok, I'm getting off topic! Best of luck in your healing endeavor mas! :D
 

Mittir

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One of the side effects of Cyproheptadine is stomach problem.
Here is a leaflet of Periactin with a list of possible side effects.
http://www.betterhealth.vic.gov.au/bhcv ... cperia.pdf
If you already have a weak digestive system as most hypothyroid people
do, then there is a good possibility that cypro can make it worse.
Though in theory it was supposed to lower serotonin and improve
digestion. I experimented with it and i got mixed results.
RP has mentioned that it one of the safest med to reduce serotonin.
So, it is worth experimenting. Good thyroid function improves digestion in various way.
 

jyb

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Mittir said:
One of the side effects of Cyproheptadine is stomach problem.

Never heard that before. How would it cause a stomach problem? In any case, I never had that kind of problem.
 

Blossom

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jyb said:
Mittir said:
One of the side effects of Cyproheptadine is stomach problem.

Never heard that before. How would it cause a stomach problem? In any case, I never had that kind of problem.
Cyproheptadine really was a pivotal turning point for my digestion as well as my outlook on life but I'm an extreme case. I'm sure it is like everything else in that it can effect people differently and knowing that information can never hurt.
 

Blossom

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thebigpeatowski said:
Did you have nausea or something with Cypro Blossom?
I had nausea before cyproheptadine. The cyproheptadine allowed me to really start eating comfortably again whereas before taking it I could hardly force myself to get the adequate nutrition I so desperately needed. That's just me though, I know everyone has a different context. I never want to give the impression that I'm advocating everyone do what I have done but I do think it is valuable to share our stories.
 
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Okay, thanks so much for clarifying! Eating enough is definitely NOT one of my issues, but I do have weird intestinal reactions on occasion that I'm sure are contributing to me not absorbing key nutrients. I'm pretty sure mast cells are involved....perhaps it's just plain ol' estrogen with me as I can't seem to pinpoint a food trigger.
 

Blossom

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thebigpeatowski said:
Okay, thanks so much for clarifying! Eating enough is definitely NOT one of my issues, but I do have weird intestinal reactions on occasion that I'm sure are contributing to me not absorbing key nutrients. I'm pretty sure mast cells are involved....perhaps it's just plain ol' estrogen with me as I can't seem to pinpoint a food trigger.
It can sure be tricky. I have noticed I better tolerate most foods these days despite a lower dose of cyproheptadine. I think for me metabolism is the key and let's face it sometimes it just takes time to get the metabolism where we want it to be! I overshot things once a few months back so I'm trying to follow Charlie's moto and take it slow. I've come to terms with the fact that I've had to put aside the 'wanting perfection now' mentality. I think some people choose to take cyproheptadine for histamine and serotonin issues with less severe problems than I was experiencing. Once again it's a highly personal and individual choice!
I noticed when I started the estro-ban I had a major change in my thyroid function for the better and I think it was related to not absorbing nutrients like you describe. Currently I'm using high doses of pregnenolone and from what I've read from Peat that can also indicate absorption issues. So I think it's safe to say I probably have some of that myself! At least I know that I'm doing everything I can to correct the situation by following this approach. I'm glad you're getting things figured out too bigpeatowski!
 

kaybb

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Current diagnostic dogma of "Fibromyalgia" is that the patient has nothing more than abnormal pain processing, and that there are no other physiological abnormalities whatsoever. Some diagnosticians claim it is nothing but depression. Many people with any number of "diagnosed" diseases get FM tacked on and get prescriptions for very expensive drugs such as Lyrica and Cymbalta which have many bad side effects.

Dr. Ignacio Blanco of Spain and associates found in their research studies that Fibromyalgia patients have mast cell proliferation in their skin and normals have much lower levels. Mast cells proliferate in bone marrow and are found all over the body- nerves,heart, brain, gut, connective tissue, etc..

Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients. - PubMed - NCBI

Dr. Blanco was forced to retire by the Spanish government. Big Pharma perhaps?

Alpha1Doc

Ray Peat's approach goes right to the core of the problem suggesting cyproheptadine, benadryl and aspirin. I was on Loratadine and Zantac as H1 & H2 blockers, but RP thinks that these are too hard on the liver.

People don't have to be covered in hives to have mast cell which degranulates and gives off serotonin and histamine (estrogen goes with this and exacerbates the serotonin release according to RP). There are other symptoms such as flushing, rapid heartbeat, blood vessel spasms, faintness… (huge list of symptoms found in all "autoimmune disease.")

I try to keep learning and adjusting in hopes that my efforts will pay off with even good health.
Can a doctor test for the mast cells or is it just more experimentation with Cypro,aspirin & Benadryl (Benadryl puts me in depression) I have terrible fibromyalgia, still struggling after follow peats methods 8 months now. Going to doc March 17th. Could talk about this. Main symptom is body pain, migraines, chronic fatigue and tiresome tinnitus. Some IBS.
Would this fall into Mast Cell problems?

Low histamine foods/diet is on Internet. Have you tried it?
Thanks for this topic. There isn't much here for fibromyalgia ....I am always searching for new insights.
 

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