Does Aspirin Degranulate Mast Cells? Or The Opposite?

lvysaur

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I was always under the impression that aspirin would degranulate mast cells, but keep them degranulated, so that aspirin would cause short term stress from histamine release, but be long term beneficial.

https://www.ncbi.nlm.nih.gov/pubmed/15763541

According to this:
ASA blocked the expression of cyclooxygenase-2, the production of tumor necrosis factor-alpha and interleukin-6, and the release of granule mediators from mast cells in a concentration-dependent fashion.

So it seems aspirin actually blocks degranulation? Additionally:
Interestingly, the expression of cyclooxygenase-2 was not inhibited at 1mM ASA, but was even enhanced significantly. The latter might contribute to the adverse effects of ASA in ASA-sensitive asthmatics.
So the COX pathway gets stronger if you take a tiny bit of aspirin, but if you exceed that, it gets inhibited.
 

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