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The vitamin C available today is not made the same way as it was during Linus Pauling's time. Ray Peat has been consistent in his position on vitamin C supplements.
Before you go down that road, here's some suggested reading:
www.hormonesmatter.com
www.hormonesmatter.com
www.hormonesmatter.com
Give it a try; I don't think there's a downside to it. I've been using hydrogenated coconut oil on my face for around 5 years; before then, I used regular coconut oil for at least 20 years. I like the hydrogenated better than the regular.
Do you think the rapamyacin is having any effect on your skin? I see that the tacromilus cream that @BigShoes was mentioning is similar to the rapa in that it is an immunosuppressant for people who have had organ transplants. Have you thought of grinding up some of the rapa, mixing it with lanolin or the coconut oil and applying it topically? How is your rapa journey coming along?
It could be. It’s been 6.5 months and going well. I basically just feel pretty good most days now and not like I’m struggling. My skin might be slightly better but it’s hard to judge since I see myself every day. I don’t notice new signs of aging but I don’t think there’s a noticeable reversal either. I’m happy with holding steady though. I have made a topical rapamycin spray and mixed some in skin cream which I’m using right now. The biggest improvements are better energy level and sleep, more stress resistant, tolerate a wider range of foods without GI issues and better oral health which I thought was fine already. I started lifting weights recently too because I feel good and motivated to increase my strength which I think is crucial for aging well. I’m planning on updating my experience in the rapamycin thread with possibly some before/after pictures and body composition comparisons from my smart scale when we get back from vacation which will be the second week in July and people can judge for themselves. It doesn’t seem miraculous or anything (like with my dog) but definitely helpful overall.
Thanks for your quick reply Blossom! Wow....lifting weights! The whole experience sounds fascinating and especially mixing the rapa spray into your skin cream. I've been thinking about adding a drop or two of MB to my homemade hyaluronic acid gel.
Topical MB is great. I put 1 500mcg drop per ounce in my lotion and love it!
Topical MB is great. I put 1 500mcg drop per ounce in my lotion and love it!
pubmed.ncbi.nlm.nih.gov
| Variables | Control group (n = 40) | Vitiligo group (n = 60) | |||||||
| Control group (n = 40) | Stable Vitiligo Patients | Active Vitiligo Patients | |||||||
| Male (n = 15) | Female (n = 25) | Total (n = 40) | Male (n = 10) | Female (n = 15) | Total (n = 25) | Male (n = 15) | Female (n = 20) | Total (n = 35) | |
| Epinephrine (pmol/L) | 350 ± 3.5 | 301.6 ± 2.08 | 319.7 ± 4.17 | 396.2 ± 3.77 | 379.2 ± 1.32 (NS) | 386 ± 2.37*** | 647.7 ± 2.89 | 588 ± 4.62 | 613.5 ± 5.83***, ### |
| Norepinephrine (nmol/L) | 2157 ± 23.22 | 1920 ± 21.59 | 2009 ± 24.26 | 2385 ± 31.53 | 2288 ± 12.16 (NS) | 2327 ± 17.20*** | 3007 ± 23.60 | 2718 ± 16.01 | 2842 ± 27.94***, ### |
| Dopamine (pmol/L) | 208.6 ± 2.17 | 179.6 ± 1.70 | 190.5 ± 2.60 | 528.1 ± 4.55 | 496.1 ± 8.34 | 508.9 ± 6.14*** | 570.5 ± 3.01 | 504.3 ± 4.65a | 532.7 ± 6.33***, ## |
| HVA (ng/mL) | 9.73 ± 0.39 | 7.92 ± 0.27 (NS) | 8.60 ± 0.26 | 24.10 ± 0.60 | 21.93 ± 0.56 (NS) | 22.80 ± 0.46*** | 31.27 ± 1.21 | 25.05 ± 1.02a | 27.71 ± 0.93***, ### |
| Serotonin (ng/mL) | 24.93 ± 0.73 | 34.16 ± 0.75 | 30.70 ± 0.89 | 55.10 ± 1.21 | 64.93 ± 0.94 | 61.0 ± 1.22*** | 74.53 ± 1.61 | 83.65 ± 1.15 | 79.74 ± 1.21***, ### |
| 5-HIAA (ng/mL) | 4.33 ± 0.15 | 6.0 ± 0.26 (NS) | 5.37 ± 0.21 | 8.30 ± 0.51 | 9.80 ± 0.48 (NS) | 9.20 ± 0.83*** | 10.60 ± 0.51a | 12.30 ± 0.31 (NS) | 11.57 ± 0.31***, ### |
| Melatonin (ng/mL) | 1.46 ± 0.08 | 2.46 ± 0.05 (NS) | 2.09 ± 0.08 | 4.90 ± 0.23 | 6.86 ± 0.44 | 6.08 ± 0.34*** | 7.0 ± 0.32 | 8.65 ± 0.43 | 7.94 ± 0.31***, ### |
That's a great find and fits my personal history. I suppose I'd consider myself at least in the stabilized category at this point. That darned stress surfaces as a major culprit once again.
This was a huge relief to finally realize as an adult. Absolutely nobody except for very deranged people think twice about some blemish on a person. People respond to your energy more than anything.
When did your vitiligo first start developing? Mine was right after puberty began. Really only active from 13-14 or so then completely stabilized and now 20 years later I'm seeing the first repigmentation with tacrolimus. Isn't a prevailing theory something involving about nervous system dysfunction? As lesions often form along certain nerves. Either symmetrical or on both sides of the body or all on one side. Puberty seems to be the most common trigger. So my theory is generationally imprinted stress adaptions might cause some kind of immune overreaction during an organisms first growth spurts when it is at its most sensitive state. Maybe why nutrition therapies don't do much at least not in one generation. There's a deep imprint at play.
) but do see a light.
I wonder if quercitin might affect conditions opposite of vitiligo, namely more freckles and odd brown splotches popping up on arms. Perhaps that is just sun damage from younger years but something has exacerbated this condition and no amount of zinc sunscreen can prevent more from coming up. Ideas anyone? I have the Heliocare + nicotinamide that my Derm recomended but it just keeps me awake at night.@BigShoes
oxidative stress is killing your melanocytes i think, and yeah bioenergetically thats generated through mitochondria dysfunction . where ATP levels are lower in the melanocytes. over time the mtDNA mutates , ROS generation gets out of control and the cell dies or loses function
so you'd want to target:
. things that help restore complex 1 activity , "In particular, we described a constitutive activation of antioxidant enzyme genes and defects in mitochondrial metabolism, reflected in an altered expression and activity of complex I, increased generation of reactive oxygen species, low ATP production"
e.g riboflavin
. things that protect/stabalize cardiolipin to restore the mitochondria function, "cardiolipin stabilization by MTP-131 recovered the energetic profle, mitochondrial structural and functional parameters, confrming that the impairment and metabolic defects observed in vitiligo melanocytes were due to the initial ETC defects"
quercetin + folic acid combo has good potential to work for the Vitiligo
Quercetin attenuates the effects of H2O2 on endoplasmic reticulum morphology and tyrosinase export from the endoplasmic reticulum in melanocytes - PubMed
Swollen endoplasmic reticulum (ER) is commonly observed in the melanocytes of vitiligo patients; however, the cause and proteins involved in this remain to be elucidated. Oxidative stress has been reported to be involved in the pathogenesis of vitiligo and previous studies have demonstrated that...
+ quercetin upregulates tyrosinase enzyme / boosts melanin in human melanocytes as well as the protection boosting survival
+ it increases complex I activity
+ it inhibits JAK which is a mechanism targetted for vitiligo
and "low" doses its anti estrogen. ~ 100mg would be needed probably but idk might work lower. 100mg is getting to high dose
would watch for if copper & iron levels lower over time if it works, as doses at least in 100s of milligrams crashes them. and better to stop taking when ill as inhibits t cells
I can't image this level of stress - I really don't know how you coped.
I don't know how she coped either! Except she is our Blossom and obviously an exceptional person who presents an inspirational and strong example for all of us. ♥
