The Dopamine Dream Team Stack

[Hans]

What's your experience like with PRL ?
Do you know which serotonin or dopamine receptors it affects ?

There's very little research on PRL with just one study showing that it increases dopamine and lowers serotonin in humans. I think it works in a way of restoring those instead of increasing or lowering them past baseline, but that's just a speculation. The reason for the speculation is because PRL enhances mental function the most in those that are the most mentally impaired, and not much or at all in those that are fine.
For me, PRL didn't do much as with most other dopaminergics.

 

[Mauritio]

There's very little research on PRL with just one study showing that it increases dopamine and lowers serotonin in humans. I think it works in a way of restoring those instead of increasing or lowering them past baseline, but that's just a speculation. The reason for the speculation is because PRL enhances mental function the most in those that are the most mentally impaired, and not much or at all in those that are fine.
For me, PRL didn't do much as with most other dopaminergics.

Ok thanks , i think it's best to cycle it . I read about someone who had side effects even 1 month after discontinuing daily use.

 

[Hans]

Ok thanks , i think it's best to cycle it . I read about someone who had side effects even 1 month after discontinuing daily use.

What kind of side effects?

 

[Mauritio]

What kind of side effects?

I think anxiety , chemical sensitivity , inability to focus .

 

[Hans]

I think anxiety , chemical sensitivity , inability to focus .

I'd say PRL is not researched enough at all so I'd only be guessing as to why. I use 10mg for a few days/weeks without much effect on its own.

 

[Mauritio]

I'd say PRL is not researched enough at all so I'd only be guessing as to why. I use 10mg for a few days/weeks without much effect on its own.

Yeah I'd say if you're otherwise healthy and dont take it everyday you should be good .
I think the main problem was his daily consumption .

 

[Mauritio]

I've tried piracetam(1200mg) for the first time yesterday. It feels very pro-metabolism and dopaminergic, but at the same time GABAergic.
I had the best sleep of the year so far. I slept so deep and it felt so restorative.
I also stepped on the scale and I lost 700g
compared to yesterday morning.

The downside is erections seem weaker and I feel a little pressure in my sinuses similarly to phenylpiracetam, but not as strong.
I also completed my experiment with phenylpiracetam a week and piracetam feels a lot less adrenergic and more GABAergic.

Although I've read that it doesnt affect the GABA receptors. It might raise the GABA/Glutamate ratio without affecting GABA as it activated the glutamate quisqualate autoreceptor, which results in a lower output of glutamate .

Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum - PubMed

The role of quisqualate (QUIS) metabotropic receptors in the synaptic transmission in the striatum was investigated using the cortico-striatal slice preparation. Low concentrations (1-30 microM) of trans-1-amino-cyclopentyl-1,3- dicarboxylic acid (t-ACPD), a selective agonist of QUIS...

pubmed.ncbi.nlm.nih.gov

 

[Mauritio]

@Hans
Have you tried low doses like 250mg ?

This study says ,
hed of 250mg decreased serotonin and increased norepinephrine In the brain and didn't effect prostaglandin E2.

An Hed of 1300mg increased serotonin, decreased norepinephrine and increased prostaglandin E2.

Effect of piracetam, a nootropic agent, on rat brain monoamines and prostaglandins - PubMed

Piracetam is the prototype of a new class of psychotropic drugs, the nootropic agents, which are claimed to selectively improve the higher telencephalic integrative activities. The effect of piracetam on rat brain monoamines and prostaglandins (PGs) was assessed so as to garner information on...

pubmed.ncbi.nlm.nih.gov

Although in this study the same amount (1300mg) decreased PGE2 and nitric oxide compared to the 4000mg dose which increased both values .
They suggest that at lower doses piracetam is an antioxidant and at higher doses a pro oxidant .

 

[Hans]

@Hans
Have you tried low doses like 250mg ?

This study says ,
hed of 250mg decreased serotonin and increased norepinephrine In the brain and didn't effect prostaglandin E2.

An Hed of 1300mg increased serotonin, decreased norepinephrine and increased prostaglandin E2.

Effect of piracetam, a nootropic agent, on rat brain monoamines and prostaglandins - PubMed

Piracetam is the prototype of a new class of psychotropic drugs, the nootropic agents, which are claimed to selectively improve the higher telencephalic integrative activities. The effect of piracetam on rat brain monoamines and prostaglandins (PGs) was assessed so as to garner information on...

pubmed.ncbi.nlm.nih.gov

Although in this study the same amount (1300mg) decreased PGE2 and nitric oxide compared to the 4000mg dose which increased both values .
They suggest that at lower doses piracetam is an antioxidant and at higher doses a pro oxidant .

No I haven't tried such low doses, but it's worth a try. A lot of studies in humans actually find that very high doses are more effective than smaller doses.

 

[Mauritio]

No I haven't tried such low doses, but it's worth a try. A lot of studies in humans actually find that very high doses are more effective than smaller doses.

It seems like theres different effects depending on the dosage . With low/medium doses beeing more nootropic and high doses more anxiolytic.

[The nootropic and anxiolytic properties of different doses of piracetam] - PubMed

The effect of piracetam at various doses on the behavioral and electrophysiological characteristics was studied, including the development of passive and active avoidance conditional reflexes in rats, their behavior in conflict situations, and the transcallosal evoked response (TER) in rabbit...

pubmed.ncbi.nlm.nih.gov

 

[Hans]

It seems like theres different effects depending on the dosage . With low/medium doses beeing more nootropic and high doses more anxiolytic.

[The nootropic and anxiolytic properties of different doses of piracetam] - PubMed

The effect of piracetam at various doses on the behavioral and electrophysiological characteristics was studied, including the development of passive and active avoidance conditional reflexes in rats, their behavior in conflict situations, and the transcallosal evoked response (TER) in rabbit...

pubmed.ncbi.nlm.nih.gov

Here's a good thread discussing various doses on humans: PIRACETAM DOSAGE - Why you should be taking 4.8 grams / dose - Brain Health

 

[Mauritio]

Here's a good thread discussing various doses on humans: PIRACETAM DOSAGE - Why you should be taking 4.8 grams / dose - Brain Health

Interesting most of the studies mentioned, administered only a single dose .
Have you ever taken that much ? If so , how did it feel compared to a lower dose ?

 

[Hans]

Interesting most of the studies mentioned, administered only a single dose .
Have you ever taken that much ? If so , how did it feel compared to a lower dose ?

The highest I've gone was around 3g lol. I also prefer to stay low dose, but I don't take it too frequently unless I really have to do mentally demanding tasks for long periods of time. Then it helps with sustaining focus, etc.

 

[Mauritio]

The highest I've gone was around 3g lol. I also prefer to stay low dose, but I don't take it too frequently unless I really have to do mentally demanding tasks for long periods of time. Then it helps with sustaining focus, etc.

Yeah me too . I liked 600 and 1200mg the most so far .
Although it does seem safe on high doses for longer timespans .
This study administered up to 20g per day for 18 months .

Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy - PubMed

Piracetam given as add-on therapy seems to be an effective, sustained, and well-tolerated treatment of myoclonus. In patients with progressive myoclonus epilepsy, the efficacy of the drug increased during the first 12 months of treatment and then stabilized.

pubmed.ncbi.nlm.nih.gov

In this study they took 8g/d for 1 year and the drug was well tolerated .

Long‐term and high‐dose piracetam treatment of Alzheimer's disease

Preclinical research suggests that piracetam (a nootropic drug) may improve cognitive functions, but previous studies have failed to demonstrate a clear benefit for the treatment of Alzheimer's disease (AD). We report a 1-year, double-blind, placebo-controlled, parallel-group study with a high...

n.neurology.org

 

[MyUsernameHere]

So I took 5g creatine and 50mg of P5P. Dopamine+DHT, how does that work you say?

I made $1400 USD in 20 seconds shorting Dogecoin, then lost it all 5 minutes later. Cratered my keyboard against the floor, there were keys everywhere (now I am typing this using the on screen keyboard lmao). After I calmed down I decided to sort out my room and cleaned out a bunch of old crap so there is that. A lot of ups and downs as opposed to the flatlined life I am used to. It feels good, but also scary , in a sense .

 

[johnsmith]

So I took 5g creatine and 50mg of P5P. Dopamine+DHT, how does that work you say?

I made $1400 USD in 20 seconds shorting Dogecoin, then lost it all 5 minutes later. Cratered my keyboard against the floor, there were keys everywhere (now I am typing this using the on screen keyboard lmao). After I calmed down I decided to sort out my room and cleaned out a bunch of old crap so there is that. A lot of ups and downs as opposed to the flatlined life I am used to. It feels good, but also scary , in a sense .

Lol

 

[Charger]

I've started using 800mg Piracetam since Wednesday and I didn't realize how dopaminergic it is. I used Piracetam for the first time around 12 years ago when I first heard about it and even less information was available and I don't recall it being so powerful, maybe it is potentiating other dopaminergics in my stack, but it has increased my energy and shot libido through the roof.

 

[Mauritio]

I've started using 800mg Piracetam since Wednesday and I didn't realize how dopaminergic it is. I used Piracetam for the first time around 12 years ago when I first heard about it and even less information was available and I don't recall it being so powerful, maybe it is potentiating other dopaminergics in my stack, but it has increased my energy and shot libido through the roof.

Nice! Did you use it daily at 800mg ?

 

[Charger]

I've been using 800mg daily since Wednesday. Will continue at that dose if no side effects appear.

 

[Mauritio]

I've been using 800mg daily since Wednesday. Will continue at that dose if no side effects appear.

Interesting !
Keep an eye on your mood ,you might need additional choline at some point . Also do you notice anything regarding your sinuses ?