1. haidut

    Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)

    Yet another "mysterious" idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike many other studies implicating metabolism in disease, this one actually manages to demonstrate that reduction of oxidative glucose metabolism is sufficient to cause severe...
  2. A

    Forced Into Fat-Burning Mode, Microglia Gobble Up Plaques, Protect Neurons

    As Aβ plaques accumulate in the brain, microglia are increasingly called upon to clean up the mess. This relentless phagocytic feasting requires enormous amounts of energy in the form of adenosine triphosphate, but by boosting glycolysis, the microglia fail to provide enough ATP, according to a...
  3. A

    Pyruvate Potentially Superior to NAD+ and Senolytics in Healthy Aging Abstract This review aimed at evoking attention of sodium pyruvate effects on healthy aging relative to the nicotinamide adenine dinucleotide oxidized form (NAD+) and senolytics. In last decades, healthy aging has become one of research hotspots in life...
  4. haidut

    Epilepsy/seizures caused by energetic deficit leading to calcium overload

    Yet another study demonstrating that not only is a chronic, "incurable" disease of unknown origin treatable but that its main cause is energetic/metabolic and linked to impaired glucose metabolism. Specifically, the study demonstrated that impaired pyruvate transport into the mitochondria is...
  5. Hans

    The best exercise and longevity booster supplement

    This is by far one of my favorite supps.
  6. haidut

    Niacinamide + pyruvate may treat glaucoma (human study)

    Some excellent results from a human clinical trial. Namely, a combination of 3g niacinamide and 3g (calcium) pyruvate daily demonstrated significant therapeutic effect in patients with already established glaucoma. I can't access to actual study link on JAMA, but I suspect the mechanism of...
  7. Hans

    The ultimate macronutrient (and supplement) for longevity and health aging!

    New study talking about pyruvate, NAD, synolytics, etc. Lots of cool stuff. View:
  8. IROM

    Degenerative Muscular Dystrophy

    Anyone have any clue about the musuclar dystrophy? My girlfriend's sister has the disease and I just want to know if Ray Peat has ever said anything about it. Is distrophin just a red herring? Most of what I see as symptomology is large amounts of pyruvate and lactate in the bloodstream which...
  9. haidut

    Reduced pyruvate and/or increased lactate drive heart failure

    I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...
  10. haidut

    Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

    About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the "irreversible" changes in eye structure seen in glaucoma patients are in fact nothing more...
  11. Hans

    An optimal metabolism: a look at the furnace within

    What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...
  12. Hans

    The Dopamine Dream Team Stack

    I've been looking far and wide and experimenting all over the place with different compounds to get see what gives me the best effects. On my quest of understanding energy metabolism and neurotransmitters, it became obvious that the two are interlinked. So I designed a stack around that. Have a...
  13. haidut

    Glucose Is Anabolic For Thymus, Opposes Catabolic Effects Of Cortisol

    As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone, and even DHT (but not by testosterone). The...
  14. haidut

    Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix

    As many forum users know, I have been interested in the Randle Cycle (glucose/fat competition for oxidation) for quite some time. The topic of limiting fatty acid oxidation (FAO) and promoting glucose oxidation is pretty central to the metabolic theory of health. Peat has written many times on...
  15. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
  16. haidut

    The Ability To Metabolize Glucose Is Impaired In CFS/ME Patients

    The enzyme pyruvate dehydrogenase (PDH) is perhaps the single most important factor in proper glucose metabolism and it is often severely downregulated (both in function and levels) in a number of diseases, most notably cancer, diabetes and neurodegenerative conditions. Without proper...
  17. P

    [Interrelationship Between Manganese, Vitamin B1 And The Level Of Pyruvic Acid]

    [Interrelationship between manganese, vitamin B1 and the level of pyruvic acid]. - PubMed - NCBI Abstract Addition of manganese to the diets promotes an increase of the total thiamine content in the blood and the liver, heart and brain tissues. This trace element appreciably changes the...
  18. haidut

    Thiamine Normalizes Pyruvate / Lactate Levels In Rats With Cancer

    Russian study, so I can't get the actual paper and see route of administration, but it was likely oral or intraperitoneal. Human equivalent dosage is 100mg - 150mg daily.
  19. haidut

    Stress-induced glycolysis is mediated by adrenalin

    A nice study that ties together the hypoglycemic state of shock with increased levels of lactate and pyruvate - all caused by adrenalin. Anti-adrenalin agents (beta "receptor" blockers) successfully ameliorated the condition. I wonder if clonidine would do the same given another study I found...
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