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danishispsychic
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yoga. specifically Gentle , Hatha 1, Restorative , Nidra . no vinyasa, power yoga , hot yoga. Pranayama breath work. Epsom Salt Baths.
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Why the break from the MB?The Methylene Blue + Sarcosine combo definitely works. Though I'd take breaks (especially from the MB). That's all I got for you.
Sarcosine is not that far from RP stuff. Sure it has some correlations with cancers (so you take breaks), but it's been thought to work through glycine reuptake inhibition (though I bet it does more than that).
Some people on Longecity noticed that taking high dose of B2 before sleep increased their thinking the next day. I'm not sure it's very physiological use of it, but it didn't hurt me badly when I tried.
It's prudent notably because MB's half life is very long. It's both mine and Ray Peat's policy to cycle and take breaks, but especially for drugs with long half-lives, imo. It's a good default.Why the break from the MB?
It's prudent notably because MB's half life is very long. It's both mine and Ray Peat's policy to cycle and take breaks, but especially for drugs with long half-lives, imo. It's a good default.
As to specific effects, hammering down NOS enzymes - iNOS notably - may affect the immune system negatively when exposed to pathogens. I'd be most careful in winter. If you're fairly healthy already you might not get any problem (pure guess), but you're not me.
On the other hand, Sarcosine has a very short half-live of a few hours, so (if you ever) you have to dose often. But that means it doesn't carry on into the night, and overall it worries me less than constant hammering the body with MB.
You might even notice it subjectively, that being on MB alone for many days, you start to feel off. It does that to me. It might be its effects on serotonin and catecholamines, or the constant nNOS antagonism in neurons. Or other. [maybe: lowering of eNOS and blood flow in the brain]
Do you think hot yoga is too stressful?yoga. specifically Gentle , Hatha 1, Restorative , Nidra . no vinyasa, power yoga , hot yoga. Pranayama breath work. Epsom Salt Baths.
Wait, do you mean you don't think the molecule should do that? I thought that was 75% of the reason to take it.How do you suppose it lowers nitric oxide?
and you follow the references from there.This letter was sent to Dr. Joshua Manghelli, who responds in this manner:
To the Editor:
Dr. Evora is indeed correct that methylene blue inhibits guanylate cyclase1; however, there are data to support the contention that it inhibits nitric oxide synthase as well.2 We believe that the figure should be adjusted to include the inhibition of both enzymes.
Wait, do you mean you don't think the molecule should do that? I thought that was 75% of the reason to take it.
I can get why you'd think it might not because of:
Methylene Blue Is a Guanylate Cyclase Inhibitor That Does Not Interfere with Nitric Oxide Synthesis
but if you look at the bottom:
and you follow the references from there.
There could be a dosage issue but I would defer to haidut on that.
Ah ok. I've never heard of some of this. Peroxynitrite is something I'd feared greatly in other context and would never consider it could possibly be involved in a two-way equilibrium. I was going to suggest hydrogen peroxide until that line about catalase, which is thoroughly discounted.Wolin, Micheal. "Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion." Journal of Pharmacology and Experimental Therapeutics (1990)
'The inhibition of vasodilation to acetylcholine or nitric oxide by methylene blue was completely prevented by suffusion of superoxide dismutase, but not affected by suffusion of catalase. Based on the current conceptualization of the mechanism of action of these vasodilator agents in isolated larger blood vessels, methylene blue appears to inhibit responses in this skeletal muscle microcirculatory preparation through the extracellular generation of superoxide anion and not via a direct interaction with guanylate cyclase.' ―Wolin
So, perhaps we ought to take this idea seriously. I think the equation below is more like an equilibrium:
I know that superoxide certainly is generated extracellularly by neutrophil NADPH oxidase, a granular enzyme secreted along with myeloperoxidase at targets. The neutrophil appears to be the immune cell that creates the most reactive small molecules extracellularly, with the macrophage of course creating the most intracellularly. The natural killer cells just release proteins such as perforin and the proteolytic granzyme—as do T cells. The neutrophil is is indisputably the most effective cell against yeast.The only clue to go on I see is the fact they believe the O2- is generated extracellularly. Or believed in 1990, anyway, already dated...
Gosh- Some people lurrrrve it. For me- it is really stressful in the Bikram form. If you are doing any of the more gentle yoga in a heated room- I think THAT can be really beneficial . The combo of super heat and super strenuous for me if kind of a wipe out.Do you think hot yoga is too stressful?
I never did bikram but I did hot power yoga which is similar. I think I destroyed my adrenals doing that for a year. Now I do a hot class once in a while but it’s mostly slow and gentle. The only standing poses are warrior 1, 2 and tree. Was curious as to why you wrote hot yoga, and I agree with you.Gosh- Some people lurrrrve it. For me- it is really stressful in the Bikram form. If you are doing any of the more gentle yoga in a heated room- I think THAT can be really beneficial . The combo of super heat and super strenuous for me if kind of a wipe out.
I just think with yoga that a classic practice is best with all asana . Really knowing all the classic asana , doing floor work, inversions and a balanced practice that is level appropriate is key. " Power Yoga " is not really Yoga in my opinion. In terms of lowering cortisol, a really balanced practice of about 90 mins that included a long nice Savasana with an Epsom Salt bath after works wonders.I never did bikram but I did hot power yoga which is similar. I think I destroyed my adrenals doing that for a year. Now I do a hot class once in a while but it’s mostly slow and gentle. The only standing poses are warrior 1, 2 and tree. Was curious as to why you wrote hot yoga, and I agree with you.
Thanks for the tipI just think with yoga that a classic practice is best with all asana . Really knowing all the classic asana , doing floor work, inversions and a balanced practice that is level appropriate is key. " Power Yoga " is not really Yoga in my opinion. In terms of lowering cortisol, a really balanced practice of about 90 mins that included a long nice Savasana with an Epsom Salt bath after works wonders.
Hey I used to get good grades in math related courses, without really stressing. That changed in my recent course. Biggest thing I learned is in the past I got free overview and structure of reading material from really good teachers. Recently though with Hubris that just showing up to class is enough. Some teacher can't provide the structure during class, they may be new to it, so you may have to make it yourself
Don't fall behind, make sure you are up to date on homework and theories, the rest will come. You should read the material at level that lets you ask competent questions in lectures, or so the teacher can look you in the eye while explaining, and you not pretending to understand, but actually do understand. Make him be the examination subject..
Do something like Anki: try to make a plan, so you see through your notes 3 times total, night after lecture, before assignments, before the next lecture, are there notes you can take to really condense the learned material into shortcuts, you can adjust accordingly, stuff like that. always maintain an overview of course material, and where you are at.
Do the assignments no matter how easy/boring/complex they seem, it's there to solidify the knowledge.
No supplement helped long term, You just gotta do it. Good luck
Your message on the other thread reminded me to ask you if you don't make the mindings: why?id go to university again if money wasnt an issue