tankasnowgod
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- Joined
- Jan 25, 2014
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I think this paper meshes very well with Peat's ideas. After reading this, I get to understand more what Peat was saying in Glucose and sucrose for diabetes. The one thing this paper diverges from Peat is its ascribing the variance of glucose uptake (as well as liver glucose production) among different people to genetics. Ray Peat ascribes this to PUFAs blocking glucose uptake.
Given insulin's role in inhibiting lipolysis and ketogenesis, as gleaned from the paper,it would be reasonable to infer that insulin promotes sugar metabolism. The consumption of fat enables fat oxidation, thus competing against glucose metabolism, and invariably lessens glucose uptake, contributing to higher blood sugar levels. And if the fat is PUFA, it also blocks glucose metabolism. Does this make a case for a low-fat dietary approach to counter diabetes?
And in the case of type II diabetes, where apart from PUFA inhibiting glucose uptake, an inability to produce sufficient insulin would make it hard to fully inhibit endogenous glucose production (by the liver), thus causing high blood sugar. Does this make a case for a high-carbohydrate approach, since both glucose and fructose would help restore the beta cells in the pancreas, thus increasing insulin production?
Kempner's approach looks to be validated. With the incorporation of Peat's ideas on PUFA elimination, even better.
It certainly seems to me like a long term low carb approach to diabetes is flawed. It seems that focusing on lowering iron would be much more beneficial. Although, I can see some merit in a lower carb approach with a focus on reducing iron stores, and cycling carbs up as iron gets near deficiency, maybe eventually ending up at what would be considered a high carb diet.
And it seems that, other than Peat, no one is really advocating getting the bulk of carbs from sugars rather than starches. I think that could also help solve a lot of problems.
By the way, Dr. Facchini had some good success with the approach of targeting iron. A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy
His experimental diet is labeled "carb restricted," but still had about 35% of calories from carbs, so more of a moderate than low carb approach.