Im currently on Vitamin B5 (2x 500mg daily of calcium pantothenate) to reduce acne as it is in medical literature described. Despite it is claimed as an safe supplement (see below) it is known in acne boards all over the web that it can induce hairloss in high doses. Therefore Im wondering what would be a safe dosage in "peat context"? Did anyone ever asked him about this? Please have a look on the rat study - does this indicate that B5 may be natural way to induce progesterone secretion?
"The results from this study indicated that the admini-stration of a pantothenic based dietary supplement in healthy human adults with mild to moderate acne vulgaris is feasi-ble, safe and well tolerated"
"Each 4tablet dose of Pantothen contain the following ingredi-ents: thiamine—1.5 mg, riboflavin—1.7 mg, niacin—20
mg, pyridoxine—2 mg, folic acid—400 mgc, cyanoco-balamin—6 mcg, biotin—300 mcg, pantothenic acid—
2.2 g and L-carnitine—733mg"
J. Capodice, "Feasibility, Tolerability, Safety and Efficacy of a Pantothenic Acid Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne Blemishes," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 3, 2012
"The results from this study indicate that the administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration. Secondary analysis shows that the study agent significantly reduced area-specific and inflammatory blemishes."
"The dosage of the study agent or the placebo administered was two tablets taken orally, twice a day with food for 12 weeks. Each four-tablet dose of the study agent contained 2.2 g of pantothenic acid."
Yang, M., Moclair, B., Hatcher, V., Kaminetsky, J., Mekas, M., Chapas, A., & Capodice, J. (2014). A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne. Dermatology and Therapy, 4(1), 93–101. A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne | SpringerLink
"Adrenal cells in pantothenic acid-treated rats ex-
hibited higher basal levels of corticosterone and progesterone than control rats. The response of ACTH and/or
PRL on corticosterone and progesterone release was higher in the pantothenic acid-treated rats than in the con-
trol rats. In addition, PRL increased the stimulatory effect of ACTH-induced corticosterone secretion in both
normal and pantothenic acid-treated rats. These results clearly demonstrated that pantothenic acid supplemen-
tation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Additionally,
these results also showed that pantothenic acid supplementation induced adrenal hyperresponsiveness to ACTH
stimulation, and PRL further stimulated adrenal sensitivity to ACTH."
Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats. (2008) Jaroenporn S1, Yamamoto T, Itabashi A, Nakamura K, Azumano I, Watanabe G, Taya K. Biol Pharm Bull. Jun;31(6):1205-8.
"The results from this study indicated that the admini-stration of a pantothenic based dietary supplement in healthy human adults with mild to moderate acne vulgaris is feasi-ble, safe and well tolerated"
"Each 4tablet dose of Pantothen contain the following ingredi-ents: thiamine—1.5 mg, riboflavin—1.7 mg, niacin—20
mg, pyridoxine—2 mg, folic acid—400 mgc, cyanoco-balamin—6 mcg, biotin—300 mcg, pantothenic acid—
2.2 g and L-carnitine—733mg"
J. Capodice, "Feasibility, Tolerability, Safety and Efficacy of a Pantothenic Acid Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne Blemishes," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 3, 2012
"The results from this study indicate that the administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration. Secondary analysis shows that the study agent significantly reduced area-specific and inflammatory blemishes."
"The dosage of the study agent or the placebo administered was two tablets taken orally, twice a day with food for 12 weeks. Each four-tablet dose of the study agent contained 2.2 g of pantothenic acid."
Yang, M., Moclair, B., Hatcher, V., Kaminetsky, J., Mekas, M., Chapas, A., & Capodice, J. (2014). A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne. Dermatology and Therapy, 4(1), 93–101. A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne | SpringerLink
"Adrenal cells in pantothenic acid-treated rats ex-
hibited higher basal levels of corticosterone and progesterone than control rats. The response of ACTH and/or
PRL on corticosterone and progesterone release was higher in the pantothenic acid-treated rats than in the con-
trol rats. In addition, PRL increased the stimulatory effect of ACTH-induced corticosterone secretion in both
normal and pantothenic acid-treated rats. These results clearly demonstrated that pantothenic acid supplemen-
tation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Additionally,
these results also showed that pantothenic acid supplementation induced adrenal hyperresponsiveness to ACTH
stimulation, and PRL further stimulated adrenal sensitivity to ACTH."
Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats. (2008) Jaroenporn S1, Yamamoto T, Itabashi A, Nakamura K, Azumano I, Watanabe G, Taya K. Biol Pharm Bull. Jun;31(6):1205-8.